Subtype	Description	Groups affected	Common features	Five-year survival rates by age (years)*
Acute lymphoblastic leukemia	> 20% lymphoblasts on bone marrow aspirate	Children and young adults (60% are diagnosed before 20 years of age)	Symptoms: easy bruising or bleeding, fatigue, fever, joint pain, pallor Signs: hepatosplenomegaly and lymphadenopathy	< 20: 87% 50 to 64: 30% ≥ 65: 15%
Acute myelogenous leukemia	> 20% myeloblasts on peripheral blood smear or bone marrow aspirate; Auer rods on peripheral smear	Adults (median age of diagnosis is 68 years)	Symptoms: central nervous system palsies, fever, pallor, thrombocytopenia Signs: flow murmur, hepatosplenomegaly, lymphadenopathy (less common)	< 50: 55% 50 to 64: 30% ≥ 65: 7%
Chronic lymphocytic leukemia	≥ 5,000 per μL (5 × 109 per L) monoclonal B lymphocytes on peripheral blood smear	Older adults (70% of new cases diagnosed after 65 years of age)	Symptoms: asymptomatic (70%) Signs: hepatosplenomegaly and lymphadenopathy	< 50: 93% 50 to 64: 91% ≥ 65: 80%
Chronic myelogenous leukemia	Philadelphia chromosome (BCR-ABL1 fusion gene)	Adults	Symptoms: asymptomatic (50%) Signs: Splenomegaly (46% to 76%)	< 50: 86% 50 to 64: 77% ≥ 65: 42%