Clinical recommendation	Evidence rating	Comments
Treatment of systemic lupus erythematosus should aim for complete remission or low disease activity and prevention of flare-ups in all organs using the lowest possible dose of glucocorticoids.19,22,23	C	Expert opinion and consensus guideline
Hydroxychloroquine is recommended for all patients with systemic lupus erythematosus.19,29	C	Consensus guideline based on inconsistent or limited-quality patient-oriented evidence
Hydroxychloroquine should be continued during pregnancy because it has been shown to control disease activity. It may reduce pregnancy complications, including preeclampsia and cardiac neonatal lupus.47–50	B	Inconsistent or limited-quality patient-oriented evidence and expert opinion
Patients with active disease should be evaluated at least every one to three months, and measurements of blood pressure, anti–double-stranded DNA antibodies, and complement and C-reactive protein levels; urinalysis; complete blood count; and kidney and liver function tests should be performed.46	C	Expert opinion and consensus guideline