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Am Fam Physician. 2023;107(6):655-656

Author disclosure: No relevant financial relationships.

TestIndicationPopulationCost*
Guardant Health Shield blood testColorectal cancer screeningAverage-risk, asymptomatic adults 45 years and older who are not up to date with colorectal cancer screening$895

Guardant Health Shield is a proprietary blood test designed to identify genomic and epigenomic alterations in cell‐free DNA and proteomic changes in plasma for early detection of colon cancer.13 The test aims to detect methylation sequences in circulating tumor DNA (ctDNA) present in the bloodstream.1,2 Although not studied for screening, ctDNA has been studied to assess the benefit of adjuvant chemotherapy after colorectal cancer surgery.4 Other early‐detection blood tests for cancer are available, although none have been approved by the U.S. Food and Drug Administration (FDA).5 Shield is not a replacement for currently recommended colorectal cancer screening methods and does not have FDA approval.6

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This series is coordinated by Natasha Pyzocha, DO, contributing editor.

A collection of Diagnostic Tests published in AFP is available at https://www.aafp.org/afp/diagnostic.

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