Organ system	Minor symptoms	Major symptoms/sequelae
Cardiovascular	Tachycardia	Hypotension, shock, syncope
Gastrointestinal	Blood or mucus in stools, colicky abdominal pain, constipation, diarrhea, fatigue, food aversion/refusal, nausea, oral pruritus, pallor, perianal redness, vomiting	Eosinophilic esophagitis, failure to thrive, growth delay, immune-mediated enterocolitis
Respiratory	Congestion, conjunctivitis, cough, nasal itching, rhinorrhea, sneezing, upper respiratory tract infection symptoms	Chest tightness, Heiner syndrome,* shortness of breath, wheezing
Skin	Acute urticaria, erythema, pruritus, worsening of atopic dermatitis	Angioedema (most commonly lips, face, and periorbital area)
Other	—	Anaphylaxis, systemic allergic reaction