Treatment	Dosage	Comments
Empagliflozin (Jardiance)	25 mg administered orally once per day	Limited evidence; not supported by guidelines or FDA approved for this indication
Salt tablets	Commonly administered as 1 g of sodium chloride three times per day; can be followed by 20 mg of furosemide	Limited evidence
Urea (oral)	Initiated at 15 to 60 g per day, often dissolved in a liquid drink to mask the taste	Considered a medical food instead of a medication; therefore, its safety has not been rigorously evaluated; the FDA says it is “generally recognized as safe,” but it is not FDA approved; some evidence shows that urea improves sodium concentration
Vaptans	Vaptans should be initiated in a hospital setting; intravenous conivaptan (Vaprisol) may be used for four days; oral tolvaptan may be used for up to 30 days, including after discharge	Should not be combined with fluid restriction because of potential for rapid sodium recovery; no evidence of long-term benefits, and use has not been assessed in severe symptomatic hyponatremia