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afp20080201p311.pdf

...better tolerated than traditional chemotherapy, but they are associated with several adverse effects, such as acneiform rash, cardiac dysfunction, thrombosis, hyperten- sion, and proteinuria. Small molecule inhibitors are metabolized by cytochrome P450 enzymes and are subject to...

American Family Physician

https://www.aafp.org/afp/2008/0201/afp20080201p311.pdf

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