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Zinc Supplementation in Children Six Months to 12 Years of Age - Cochrane for ...

Jan 1, 2015 - Preventive zinc supplementation for children in low- and middle-income countries appears to reduce rates of diarrhea and may slightly reduce rates of growth failure.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0101/p27.html

Colchicine for Acute Gout - Cochrane for Clinicians - American Family Physician

Jun 1, 2015 - Low-quality evidence shows that low-dose colchicine (up to 1.8 mg over one hour) is an effective therapy for acute gout.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0601/p759.html

Alpha Blockers to Speed Ureteral Stone Passage - Cochrane for Clinicians - American ...

Feb 1, 2015 - Compared with patients receiving standard therapy (e.g., fluids, analgesics), placebo, or calcium channel blockers, patients receiving alpha blockers had about three fewer days to ureteral stone expulsion and were less likely to be hospitalized. Adverse effects of alpha blocker therapy ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0201/p164.html

Pharmacologic Therapy for Gastroesophageal Reflux Disease in Children - Cochrane for ...

Sep 1, 2015 - Among infants younger than 12 months diagnosed with GERD, weak evidence supports the use of proton pump inhibitors (PPIs) and histamine H2 antagonists. Among children 12 months and older, studies have shown moderate benefit from PPIs and weak benefit from H2 antagonists for providing ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0901/p351.html

Magnesium Sulfate for Prevention of Preterm Birth - Cochrane for Clinicians - American ...

Apr 1, 2015 - Magnesium sulfate does not delay delivery when used in patients with preterm labor. Although magnesium sulfate is not associated with any serious adverse maternal outcomes, it may be associated with an increase in total fetal, neonatal, and infant mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0401/p444.html

Aclidinium for Stable COPD - Cochrane for Clinicians - American Family Physician

Jun 1, 2015 - Aclidinium did not decrease all-cause mortality or exacerbations requiring oral steroids, antibiotics, or both. However, aclidinium decreased the number of patients with exacerbations requiring hospitalization and improved quality of life in those with stable COPD.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0601/p760.html

Immediate-Release Methylphenidate for the Treatment of ADHD in Adults - Cochrane for ...

Apr 1, 2015 - In adults with ADHD, immediate-release methylphenidate improves symptoms of hyperactivity, impulsiveness, and inattentiveness compared with placebo. Short-term adverse effects such as weight loss and decreased appetite do not appear to be serious. However, larger studies of longer ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0401/p445.html

Risk of Venous Thromboembolism with Use of Combined Oral Contraceptives - Cochrane for ...

Mar 1, 2015 - All combined oral contraceptives increase VTE risk. The risk is greater for those containing desogestrel, drospirenone, gestodene (not available in the United States), and cyproterone acetate (not available in the United States) when compared with levonorgestrel. All combined oral ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0301/p287.html

Buprenorphine Maintenance vs. Methadone Maintenance or Placebo for Opioid Use Disorder ...

Feb 1, 2015 - At dosages greater than 2 mg per day, buprenorphine maintains treatment retention better than placebo. When flexible dosing (doses adjusted based on patient symptoms) is used, the effectiveness of buprenorphine is comparable to that of methadone in suppressing opioid use.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0201/p165.html

Controlled-Release Oxycodone for Neuropathic Pain and Fibromyalgia in Adults - Cochrane...

Mar 1, 2015 - Oxycodone CR has limited effectiveness for the treatment of diabetic neuropathy or postherpetic neuralgia. Evidence is lacking regarding treatment benefit for other neuropathic pain syndromes or fibromyalgia. Adverse effects of oxycodone CR therapy are common.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0301/p286.html

Methotrexate Therapy for Rheumatoid Arthritis - Cochrane for Clinicians - American ...

Jan 1, 2015 - Methotrexate monotherapy demonstrated statistically significant and clinically relevant improvement of symptoms and physical function compared with placebo at 12 to 52 weeks. Multiple adverse effects were reported with methotrexate use, and patients were twice as likely to discontinue ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0101/p26.html

Bronchodilators for Bronchiolitis - Cochrane for Clinicians - American Family Physician

Nov 1, 2014 - Albuterol does not improve any clinical outcomes in the outpatient or inpatient setting and should not be used in the treatment of bronchiolitis in a child 24 months or younger.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/1101/p622.html

Safety of Long-Acting Beta Agonists in Adults with Asthma - Cochrane for Clinicians - ...

Oct 1, 2014 - LABAs appear to be safe when used with inhaled corticosteroids. LABA monotherapy is associated with an increase in asthma-related mortality and nonfatal serious adverse events, but not in all-cause mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/1001/p453.html

Intranasal Corticosteroids for Acute Bacterial Sinusitis - Cochrane for Clinicians - ...

Sep 1, 2014 - Compared with patients not treated with intranasal corticosteroids, those who receive them have greater improvement or resolution of symptoms at two to three weeks, regardless of whether antibiotics are used. In a single head-to-head study, patients taking intranasal corticosteroids ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0901/p286.html

Psychological Therapies for Chronic Posttraumatic Stress Disorder - Cochrane for ...

Oct 1, 2014 - Trauma-focused cognitive behavior therapy (CBT) and eye movement desensitization and reprocessing (EMDR) are more effective than other therapies in reducing PTSD symptom severity up to four months after treatment, but more robust studies are needed to evaluate the long-term effectiveness.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/1001/p454.html

Exercise Programs for Older Patients with Dementia - Cochrane for Clinicians - American...

Sep 1, 2014 - There is some evidence that exercise improves cognitive function and the ability to perform activities of daily living in patients with dementia.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0901/p287.html

Antibiotics for Sore Throat - Cochrane for Clinicians - American Family Physician

Jul 1, 2014 - Compared with placebo, antibiotics can shorten the duration of sore throat symptoms by about 16 hours and can reduce complications. In countries where the absolute rates of complications are higher, antibiotic therapy is more likely to be effective. The effectiveness of antibiotic ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0701/p23.html

Collaborative Care for Depression and Anxiety - Cochrane for Clinicians - American ...

Apr 1, 2014 - The collaborative care model is effective for treating adults with depression and/or anxiety using a multiprofessional approach to patient care, a structured management plan, scheduled patient follow-ups, and enhanced interprofessional communication.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0401/p524.html

Prophylactic Antibiotics for the Prevention of COPD Exacerbation - Cochrane for ...

Jun 1, 2014 - Continuous prophylactic antibiotic therapy significantly decreases COPD exacerbations for up to three years. However, it does not decrease mortality, and it puts the patient at risk of antibiotic-resistant colonization and infection.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0601/p870.html

Early Developmental Intervention Programs for Preterm Infants - Cochrane for Clinicians...

Mar 1, 2014 - Early intervention programs improve cognitive performance in preterm infants up to 36 months of age, but no effect can be detected by five years of age. A small effect of early intervention on motor performance was found in infancy, but it did not persist until preschool or school age.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0301/p336.html

Role of Breathing Exercises in the Treatment of COPD - Cochrane for Clinicians - ...

Jan 1, 2014 - Patients with COPD who are treated with breathing exercises vs. standard care showed an improvement in exercise capacity, with inconsistent changes in dyspnea and health-related quality of life. Adding breathing exercises to a pulmonary rehabilitation program did not show any increased ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0101/p15.html

Aspirin With or Without Antiemetic for Acute Migraine Headaches in Adults - Cochrane ...

Feb 1, 2014 - Aspirin, with or without an antiemetic, is an effective treatment for acute migraine headache. Adding the antiemetic metoclopramide (Reglan) significantly reduces migraine-related nausea and vomiting compared with aspirin alone.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0201/p176.html

Corticosteroids for the Treatment of Sore Throat - Cochrane for Clinicians - American ...

Jan 1, 2014 - In adults with suspected bacterial pharyngitis who require antibiotic therapy, adding a corticosteroid may increase the likelihood of complete pain resolution at 24 hours. Further study is needed to assess the safety of corticosteroids and whether they can be recommended for presumed ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0101/p14.html

Are Cranberry Products Effective for the Prevention of Urinary Tract Infections? - ...

Dec 1, 2013 - Cranberry products are not effective and should not be recommended for the prevention of UTIs.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/1201/p745.html

Optimal Antibiotic Regimen for Treating Lower UTI in Children - Cochrane for Clinicians...

Nov 1, 2013 - For the afebrile child with a UTI, a short course (three to seven days) of antibiotics is as effective at preventing the recurrence of symptomatic UTI as a long course (seven to 10 days). There is no clear evidence of superiority for any one antibiotic regimen.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/1101/p577.html

Ultrasound-Guided Steroid Injections for Shoulder Pain - Cochrane for Clinicians - ...

Oct 1, 2013 - Ultrasound-guided glucocorticoid injection for shoulder pain provides no advantage over landmark-guided or intramuscular injection in terms of pain, function, range of motion, or safety when measured within a six-week follow-up period. However, the small sample size of this review means...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/1001/p433.html

Pharmacotherapy for Mild Hypertension - Cochrane for Clinicians - American Family ...

Jul 1, 2013 - Pharmacologic treatment of mild hypertension for up to five years does not reduce coronary events, stroke, or mortality compared with placebo.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0701/p21.html

Minocycline for Acne Vulgaris - Cochrane for Clinicians - American Family Physician

Sep 1, 2013 - Compared with placebo, minocycline generally improves acne, but it offers no clinical advantages over other therapies and has more serious adverse effects.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0901/p300.html

Oxytocin Augmentation During Labor with Epidural Analgesia - Cochrane for Clinicians - ...

Jun 1, 2013 - Oxytocin augmentation does not reduce the frequency of cesarean delivery, instrumental vaginal delivery, or the combined outcome of both. Oxytocin also has no effect on low five-minute Apgar scores, postpartum hemorrhage, uterine hyperstimulation, or neonatal intensive care unit ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0601/p760.html

Contraceptive Education for Women After Childbirth - Cochrane for Clinicians - American...

Jun 1, 2013 - Postpartum education may increase contraceptive use and reduce unplanned repeat pregnancies, although the evidence is mixed. The optimal timing and content of educational programs are not known.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0601/p761.html

Appropriate Use of Polypharmacy for Older Patients - Cochrane for Clinicians - American...

Apr 1, 2013 - Multidisciplinary interventions that address polypharmacy decrease inappropriate prescribing and medication-related problems in patients 65 years and older, but it is not clear if they reduce hospital admissions or improve quality of life. Most interventions studied were led by ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0401/p483.html

Effect of Cocoa on Blood Pressure - Cochrane for Clinicians - American Family Physician

Apr 1, 2013 - Consuming 50 g of cocoa daily will lower blood pressure 2 to 3 mm Hg on average in adults with hypertension. Evidence of improved patient-oriented outcomes does not exist.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0401/p484.html

Physical Training for Patients with Asthma - Cochrane for Clinicians - American Family ...

Mar 1, 2013 - Physical training lasting for at least 20 to 30 minutes, two to three times a week for at least six weeks, improves physical fitness in patients with asthma. Physical training is not associated with worsening of asthma symptoms, and it improves health-related quality of life.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0301/p313.html

Caffeine as an Analgesic Adjuvant for Acute Pain in Adults - Cochrane for Clinicians - ...

Jan 1, 2013 - Overall, there appears to be a small but clinically significant benefit to adding caffeine to analgesic therapy for various types of acute pain. More research is needed to determine the optimal dosing.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0101/p11.html

Steroids for the Treatment of Otitis Media with Effusion in Children - Cochrane for ...

Feb 1, 2012 - Oral steroid use, alone or in combination with antibiotics, speeds the resolution of otitis media with effusion. However, there is no evidence that oral steroids improve symptoms or affect long-term outcomes, such as hearing loss. Topical nasal steroids have no effect on otitis media ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0201/p235.html

Oral Antihistamine/Decongestant/Analgesic Combinations for the Common Cold - Cochrane ...

Nov 1, 2012 - Combination cold medications, including antihistamine/decongestant/analgesic, antihistamine/decongestant, antihistamine/analgesic, and analgesic/decongestant formulations, provide modest symptom relief in adults and older children, but are not effective in young children. Only the ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/1101/p812.html

Insulin for Glycemic Control in Acute Ischemic Stroke - Cochrane for Clinicians - ...

Dec 1, 2012 - Administering insulin to maintain glycemic control does not improve the rates of mortality or dependency, or the final neurologic outcome after an acute ischemic stroke. Additionally, in randomized controlled trials, patients in the intervention groups (those under tight glycemic ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/1201/p1008.html

The Effects of Combination Contraceptives on Weight - Cochrane for Clinicians - ...

Dec 1, 2012 - Compared with placebo or no intervention, the use of combination contraceptives was not associated with weight gain. Most studies comparing different types of combination contraceptives showed no statistically significant effects on weight.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/1201/p1009.html

Are Neuraminidase Inhibitors Effective for Preventing and Treating Influenza in Healthy...

Oct 1, 2012 - Treating previously healthy patients with oseltamivir (Tamiflu) reduces the duration of influenza symptoms by approximately 21 hours, but it does not reduce the risk of hospitalization in this population.1 The data are insufficient to determine whether oseltamivir reduces the ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/1001/p624.html

Amphetamines for Attention-Deficit/Hyperactivity Disorder in Adults - Cochrane for ...

Sep 1, 2012 - Amphetamines improve ADHD symptom severity but, when compared with placebo, they are associated with increased discontinuation rates because of adverse effects. There does not appear to be a difference among dosages or between the immediate- and sustained-release formulations.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0901/p413.html

Weight Loss for Patients with Nonalcoholic Fatty Liver Disease - Cochrane for ...

Sep 1, 2012 - There are insufficient high-quality studies to determine patient-oriented outcomes of weight loss for the treatment of fatty liver disease. Nonetheless, weight loss remains a reasonable goal because it may reduce liver inflammation and improve comorbidities. In two of the studies ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0901/p415.html

Epidural Analgesia for Labor Pain - Cochrane for Clinicians - American Family Physician

Aug 1, 2012 - Compared with other types of analgesia or no analgesia, epidurals offered better pain relief, but were associated with a longer second stage of labor and increased risk of instrumental vaginal delivery, maternal fever, and oxytocin (Pitocin) administration. There were no statistically ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0801/p241.html

Antidepressants for Agitation and Psychosis in Patients with Dementia - Cochrane for ...

Jan 1, 2012 - There are few high-quality studies examining the effectiveness of antidepressants for treating the neuropsychiatric symptoms of dementia. Although there is some evidence to support the use of the selective serotonin reuptake inhibitors (SSRIs) sertraline (Zoloft) and citalopram ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0101/p20.html

Self-Monitoring of Blood Glucose in Patients with Type 2 Diabetes Not Using Insulin - ...

May 1, 2012 - For patients who have had diabetes longer than one year and are not using insulin, evidence suggests that the benefit of self-monitoring of blood glucose in lowering A1C levels is small at six months and disappears by 12 months. Self-monitoring of blood glucose does not improve ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0501/p866.html

Antiretroviral Therapy to Prevent Transmission in HIV-Discordant Couples - Cochrane for...

Mar 1, 2012 - Rates of HIV transmission are at least three times lower in HIV-discordant couples in which the partner with infection is receiving antiretroviral therapy, compared with HIV-discordant couples in which the partner with infection is not receiving therapy. Among HIV-discordant couples in ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0301/p445.html

Exercise for Treatment of the Vasomotor Symptoms of Menopause - Cochrane for Clinicians...

Feb 1, 2012 - Although menopausal women who exercise are less likely to report vasomotor symptoms than those who do not, there is insufficient evidence that counseling women to exercise is more effective than no treatment or hormone therapy for vasomotor symptoms of menopause.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0201/p237.html

Management of Constipation in Patients Receiving Palliative Care - Cochrane for ...

Dec 1, 2011 - There is insufficient evidence to recommend one laxative over another for the treatment of constipation in patients receiving palliative care. Methylnaltrexone can increase the frequency of bowel movements at four hours (odds ratio = 7.0; 95% confidence interval, 3.8 to 12.6) and at 24 ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/1201/p1227.html

Opioid Antagonists for the Treatment of Alcohol Dependence - Cochrane for Clinicians - ...

Nov 1, 2011 - Although it does not improve overall alcohol abstinence rates, the oral formulation of the opioid antagonist naltrexone (Revia) is moderately effective in decreasing the amount and frequency of alcohol consumption in patients with alcohol dependence.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/1101/p990.html

Cognitive Interventions for Improving Cognitive Function - Cochrane for Clinicians - ...

Nov 1, 2011 - Compared with no treatment, cognitive interventions improved cognitive performance in healthy older adults and older adults with mild cognitive impairments. However, there is inadequate evidence to determine which aspects of these interventions are effective.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/1101/p992.html

Nicotine Receptor Partial Agonists for Smoking Cessation - Cochrane for Clinicians - ...

Oct 1, 2011 - Compared with placebo, varenicline more than doubles the chances of successful long-term smoking abstinence. In head-to-head trials, varenicline appears to be at least as effective as nicotine replacement therapy and bupropion (Zyban). The most common adverse effect is nausea, which ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/1001/p769.html

GERD Treatment for Chronic Nonspecific Cough in Children and Adults - Cochrane for ...

Sep 1, 2011 - Acid suppressants or prokinetic agents should not be used to treat chronic nonspecific cough in infants or children. There is insufficient evidence to support or discourage use of these agents to treat chronic non-specific cough in adults, even in those with a history of GERD.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0901/p502.html

Magnesium Sulfate and Other Anticonvulsants for Women with Preeclampsia - Cochrane for ...

Jun 1, 2011 - Magnesium sulfate should be considered first-line treatment to prevent eclamptic seizures during labor.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0601/p1269.html

Probiotics for Persistent Diarrhea in Children - Cochrane for Clinicians - American ...

Jul 1, 2011 - Limited data suggest that probiotic use decreases duration and frequency of loose stools, and reduces length of hospital stay in children with persistent diarrhea. One high-quality study showed Lactobacillus rhamnosus GG to be effective. Probiotics are generally well tolerated.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0701/p25.html

Effectiveness of Bronchodilators for Bronchiolitis Treatment - Cochrane for Clinicians ...

May 1, 2011 - Bronchodilators may transiently improve the clinical status of infants with bronchiolitis and no prior history of wheezing. However, moderately strong evidence shows that key outcomes such as oxygen saturation, need for hospitalization, length of hospitalization, and duration of ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0501/p1045.html

Clozapine vs. Other Atypical Antipsychotics for Schizophrenia - Cochrane for Clinicians...

Feb 1, 2011 - Although further trials are needed, there is some evidence that clozapine is slightly more effective than risperidone (Risperdal). Fewer participants taking clozapine dropped out of studies because of lack of effectiveness compared with those taking risperidone (number needed to treat =...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0201/p260.html

Effectiveness of Acamprosate in the Treatment of Alcohol Dependence - Cochrane for ...

Mar 1, 2011 - When used in conjunction with detoxification and psychosocial interventions for treating alcohol dependence, acamprosate can reduce the risk of any return to drinking and improve cumulative abstinence rates.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0301/p522.html

Preoperative Testing for Patients Undergoing Cataract Surgery - Cochrane for Clinicians...

Dec 1, 2009 - Routine preoperative testing before cataract surgery does not reduce intraoperative or postoperative complications.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/1201/p1228.html

Stage-Based Interventions for Smoking Cessation - Cochrane for Clinicians - American ...

Mar 1, 2011 - Although providing stage-based smoking cessation interventions for those trying to quit appears to be more effective than not intervening at all, the evidence does not support tailoring interventions to a patient's perceived motivational stage of change.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0301/p524.html

Chest Physiotherapy for Pneumonia in Adults - Cochrane for Clinicians - American Family...

Dec 1, 2010 - There is little evidence to support the effectiveness of chest physiotherapy for adults with pneumonia. In two small studies by the same investigator, only osteopathic manipulation was shown to improve some outcomes (i.e., length of stay and duration of antibiotic therapy).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/1201/p1340.html

Short Course of Antibiotics for Acute Otitis Media Treatment - Cochrane for Clinicians ...

Jan 1, 2011 - Antibiotic courses between two and seven days in duration are associated with a slightly higher risk of treatment failure than longer courses (number needed to treat = 33), but also a somewhat lower risk of adverse gastrointestinal effects (number needed to harm = 29). Ceftriaxone ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0101/p37.html

Usefulness of Measuring Antiepileptic Medication Blood Levels in Patients with Epilepsy...

Nov 1, 2010 - When treating a patient for epilepsy, there is not enough evidence to indicate if optimal seizure control is best obtained by routinely measuring medication levels compared with making adjustments based on the clinical picture.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/1101/p1070.html

Does Metformin Increase the Risk of Fatal or Nonfatal Lactic Acidosis? - Cochrane for ...

Nov 1, 2010 - In patients without standard contraindications to metformin therapy, metformin does not increase the risk of lactic acidosis.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/1101/p1068.html

Aripiprazole vs. Other Atypical Antipsychotics for Schizophrenia - Cochrane for ...

Jun 1, 2010 - Aripiprazole is less effective in treating schizophrenia than olanzapine (Zyprexa), but has fewer metabolic and sedative adverse effects. There is no difference in effectiveness between aripiprazole and risperidone (Risperdal); however, aripiprazole may be associated with less dystonia,...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0601/p1335.html

Effectiveness of Antidepressants Compared with Placebo for Depression in Primary Care -...

Jul 1, 2010 - Tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) are more effective than placebo for the treatment of depression in primary care settings.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0701/p42.html

Hypothermia for Neuroprotection in Adults After Cardiopulmonary Resuscitation - ...

Sep 1, 2010 - Compared with standard care, therapeutic hypothermia with conventional cooling methods improves the rate of survival to hospital discharge and neurologic outcome in patients successfully resuscitated after cardiac arrest.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0901/p477.html

Medical Management vs. Surgery for Gastroesophageal Reflux Disease - Cochrane for ...

Aug 1, 2010 - At one to three years, adults with GERD who were treated with laparoscopic fundoplication had more improvement in overall and GERD-specific quality of life scores and less exposure to acid in the lower esophagus compared with patients who use proton pump inhibitors (PPIs) and histamine ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0801/p244.html

Neuraminidase Inhibitors for Influenza Treatment and Prevention in Healthy Adults - ...

Aug 1, 2010 - Although neuraminidase inhibitors can reduce the risk of contracting symptomatic, confirmed influenza and reduce the time to recovery for those with laboratory-confirmed influenza, they are not effective for reducing the risk of influenza-like illness or asymptomatic influenza infection...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0801/p242.html

Opioid Therapy for Chronic Noncancer Pain - Cochrane for Clinicians - American Family ...

Jul 1, 2010 - Weak evidence suggests that opioids reduce chronic noncancer pain in some highly selected patients, although the effects on quality of life and functional status are unclear.1 Many patients will discontinue opioids because of adverse effects or inadequate pain relief.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0701/p40.html

Blood Pressure Treatment Targets for Uncomplicated Hypertension - Cochrane for ...

Apr 1, 2010 - To date, there is no evidence to support treating patients with uncomplicated hypertension to blood pressure goals lower than the standard blood pressure target of less than or equal to 140 to 160/90 to 100 mm Hg. In randomized controlled trials, patients treated to lower blood pressure...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0401/p848.html

Opioids for Osteoarthritis of the Knee or Hip - Cochrane for Clinicians - American ...

May 1, 2010 - Compared with placebo, the benefits achieved from opioid therapy are modest in terms of pain relief and improvement in function, and do not outweigh the increase in adverse effects. No single opioid stands out as more effective or safer than the rest.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0501/p1094.html

Risperidone vs. Placebo for Schizophrenia - Cochrane for Clinicians - American Family ...

May 1, 2010 - Compared with placebo, risperidone improves symptoms based on some disease-specific symptom scores for schizophrenia. However, it does not appear to improve symptoms on a more important Clinical Global Impression scale.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0501/p1096.html

Addition of Long-Acting Beta Agonists for Asthma in Children - Cochrane for Clinicians ...

Mar 1, 2010 - In children with persistent asthma who are already taking inhaled corticosteroids, the addition of a LABA does not lower the rate of exacerbations requiring oral steroids, rescue medication, or hospitalizations, but it improves measurable lung function.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0301/p598.html

Topical Treatments for Chronic Plaque Psoriasis - Cochrane for Clinicians - American ...

Mar 1, 2010 - Topical vitamin D analogues, corticosteroids, anthralin, and tazarotene (Tazorac) are all more effective than placebo. Vitamin D and high-potency corticosteroids were equally effective when compared head to head, but were more effective in combination than either product alone. Vitamin ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0301/p596.html

Corticosteroid Injections for Trigger Finger - Cochrane for Clinicians - American ...

Sep 1, 2009 - Based on limited evidence, corticosteroid injection combined with lidocaine (Xylocaine) was more effective than lidocaine alone for the treatment of trigger finger in adults. Compared with those who received lidocaine alone, 38 percent more of the patients who received corticosteroid ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0901/p454.html

Statins for Non-Dialysis Chronic Kidney Disease - Cochrane for Clinicians - American ...

Jan 1, 2010 - When taken over a five-year period, statins significantly reduce all-cause mortality (number needed to treat [NNT] = 56), cardiovascular mortality (NNT = 86), and nonfatal cardiovascular events (NNT = 25).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0101/p27.html

Interventions to Help Patients Reduce or Eliminate the Use of Smokeless Tobacco - ...

Dec 1, 2009 - Although the studies of behavior interventions were heterogeneous in this Cochrane review, behavior interventions such as mailings, oral or dental screenings, group discussions, workplace interventions, and telephone support showed the best evidence for smokeless tobacco cessation.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/1201/p1226.html

Cochrane for Clinicians - Oct 1, 2005 - American Family Physician

Oct 1, 2005 - Although no difference in effectiveness has been demonstrated in existing trials, too few patients have been studied to detect small but clinically important differences in pregnancy rates. Low-dose estrogen pills have higher rates of discontinuation and bleeding disturbances.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/1001/p1224a.html

Low Glycemic Index Diets for the Management of Diabetes - Cochrane for Clinicians - ...

Nov 1, 2009 - The low glycemic index diet (sometimes called a low glycemic load diet) lowered the A1C level by a weighted mean difference of 0.5 percent when compared with a high glycemic index (or glycemic load) diet. Fewer episodes of hypoglycemia occurred with a low glycemic index diet compared ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/1101/p941.html

Same-Day Initiation of Hormonal Contraceptives - Cochrane for Clinicians - American ...

Oct 1, 2009 - Giving an injection of medroxyprogesterone (Depo-Provera) on any day of a patient's menstrual cycle decreases unintended pregnancies. For other hormonal methods, there is limited evidence. Compared with deferring until the patient's next menses, immediate start of hormonal methods ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/1001/p690.html

Exercise for the Management of Cancer-Related Fatigue - Cochrane for Clinicians - ...

Oct 1, 2009 - Aerobic and resistance-training exercise programs lead to decreased overall fatigue and an improved quality of life during and after treatment of cancer.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/1001/p689.html

Is Oral Vitamin B12 as Effective as Intramuscular Injection? - Cochrane for Clinicians ...

Jan 1, 2006 - In patients with vitaminB12 deficiency, two oral regimens have been shown to achieve neurologic and hematologic response in the short term. Effective dosages were (1) 2,000 mcg daily or (2) 1,000 mcg daily for 10 days, then weekly and monthly.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0101/p65.html

Vaccines for Postexposure Prophylaxis Against Varicella (Chicken Pox) - Cochrane for ...

Sep 1, 2009 - Varicella vaccine appears to be effective in preventing or modifying the severity of the disease in healthy unvaccinated children if administered within three days of exposure. Data are insufficient to support or refute the use of the vaccine as postexposure prophylaxis in adults and ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0901/p455.html

Heparins for Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction - ...

Apr 1, 2009 - Compared with standard therapy with aspirin, the use of heparin does not reduce mortality, the need for revascularization, and recurrent angina. Heparin does reduce the occurrence of myocardial infarction (MI; number needed to treat [NNT] = 33), defined as typical chest pain associated ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0401/p560.html

Contraceptive Patch and Vaginal Ring vs. Combined Oral Contraceptives - Cochrane for ...

Aug 1, 2009 - Based on moderate quality evidence, contraceptive effectiveness of the vaginal ring or patch is similar to COC. Compliance is better with the patch, but its use is discontinued more often than COCs or the ring because of adverse effects. Vaginal ring and COC users have similar rates of ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0801/p232.html

Should Salmeterol Be Used for Long-Term Asthma Control? - Cochrane for Clinicians - ...

Jun 1, 2009 - Salmeterol may help improve asthma symptoms, but it should only be used as part of a comprehensive asthma management plan including inhaled corticosteroids and a short-acting beta agonist. There is currently insufficient evidence to confirm that salmeterol does not increase the risk of ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0601/p957.html

Dopamine Agonists for Early Parkinson Disease - Cochrane for Clinicians - American ...

Jul 1, 2009 - Dopamine agonists, such as pramipexole (Mirapex), ropinirole (Requip), pergolide (formerly Permax), and apomorphine (Apokyn), improve the motor fluctuations and dyskinesias that commonly occur with levodopa, but at the expense of increasing nonmotor adverse effects and noncompliance. An...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0701/p28.html

Anticoagulation for the Long-term Treatment of VTE in Patients with Cancer - Cochrane ...

Jul 1, 2009 - Although LMWH appears to be more effective than oral anticoagulants in the prevention of recurrent VTE, this does not translate into a survival benefit. LMWH and oral anticoagulants have the same reported adverse events of bleeding and thrombocytopenia.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0701/p30.html

Custom vs. Prefabricated Orthoses for Foot Pain - Cochrane for Clinicians - American ...

May 1, 2009 - Compared with placebo or sham, custom-made foot orthoses modestly reduce foot pain from pes cavus (high arch), arthritis, plantar fasciitis, and painful hallux valgus. However, there is no evidence that custom orthoses are more effective than prefabricated ones.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0501/p758.html

Antibiotics for Acute Maxillary Sinusitis - Cochrane for Clinicians - American Family ...

May 1, 2009 - Although there is some evidence that antibiotics are effective in the treatment of acute uncomplicated sinusitis, this benefit is modest. Most patients with acute sinusitis improve within two weeks without antibiotics. The potential risk of adverse effects from antibiotics may outweigh ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0501/p757.html

Effectiveness of Brief Alcohol Interventions in Primary Care - Cochrane for Clinicians ...

Mar 1, 2009 - For men who engage in excessive or hazardous drinking and present to their primary care physician for issues not specifically related to alcohol treatment, an intervention of one to four sessions administered by a physician, nurse, or psychologist is effective in reducing weekly alcohol...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0301/p370.html

Dipeptidyl-peptidase-4 Inhibitors for Treatment of Type 2 Diabetes - Cochrane for ...

Mar 1, 2009 - When used as monotherapy or in conjunction with metformin (Glucophage) or thiazolidinediones, the DPP-4 inhibitor sitagliptin (Januvia) decreases A1C levels by 0.7 percent, but there are no data on patient-oriented outcomes or long-term safety. Until more studies are completed, it ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0301/p372.html

Antioxidant Supplements Do Not Improve Mortality and May Cause Harm - Cochrane for ...

Nov 1, 2008 - In randomized controlled trials of primary and secondary prevention, vitamins A and E, and beta-carotene supplementation increased mortality. Vitamin C and selenium supplementation had no significant effect on mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/1101/p1079.html

Alendronate for Fracture Prevention in Postmenopause - Cochrane for Clinicians - ...

Sep 1, 2008 - In postmenopausal women, a 10-mg daily dose of alendronate is effective for secondary (number needed to treat [NNT] = 16) and primary (NNT = 50) prevention of vertebral fractures. It is also effective for secondary prevention of nonvertebral fractures, including hip or wrist fractures ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0901/p579.html

Cranberry Products for Treatment of Urinary Tract Infection - Cochrane for Clinicians -...

Aug 1, 2008 - Over a 12-month period, cranberry products decrease the incidence of symptomatic urinary tract infections (UTIs), especially in women with recurrent UTIs. Optimal dosage and form of administration (juice, tablets, or capsules) is unclear. There are no studies comparing cranberry juice ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0801/p332.html

Oral Anticoagulants vs. Antiplatelet Therapy - Cochrane for Clinicians - American ...

May 1, 2008 - Compared with antiplatelet therapy, oral anticoagulation significantly reduces stroke at an average follow-up of one to three years, but does not reduce mortality. Intracranial or extracranial hemorrhage is more common with anticoagulation and must be weighed against its therapeutic ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0501/p1250.html

Arthroscopic Surgery for Knee Osteoarthritis - Cochrane for Clinicians - American ...

Aug 1, 2008 - Compared with other modalities of treatment such as sham surgery, joint lavage, and joint washout, arthroscopic debridement does not improve outcomes for patients with osteoarthritis of the knee.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0801/p331.html

Over-the-Counter Medications for Acute Cough Symptoms - Cochrane for Clinicians - ...

Jul 1, 2008 - It is uncertain whether OTC cough medications are effective in reducing cough symptoms in adults; in children, no trials show a statistically significant benefit in the treatment compared with the placebo groups. Overall, the quality of evidence is poor; adult studies show conflicting ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0701/p52.html

Interventions to Improve Blood Pressure Control in Patients with Hypertension - ...

Aug 1, 2007 - One large study of adults with hypertension showed that a rigorous, systematic program including regular patient review and aggressive antihypertensive drug therapy improved systolic and diastolic blood pressure and reduced all-cause mortality (7.8 to 6.4 percent at five years; number ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0801/p373.html

Antidepressants to Treat Nonspecific Low Back Pain - Cochrane for Clinicians - American...

Jul 1, 2008 - Although antidepressants have been shown to be superior to placebo in some forms of chronic pain, they do not reduce pain or improve functional status or depression in patients with nonspecific low back pain.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0701/p51.html

Are SSRIs Effective for Treating OCD? - Cochrane for Clinicians - American Family ...

May 1, 2008 - SSRIs are effective for the treatment of OCD. If it is assumed that 10 percent of persons with OCD will recover without treatment, then 12 persons with OCD need to be treated for one additional person to have a response within six to 13 weeks. If it is assumed that 20 percent of persons...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0501/p1252.html

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