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Laxatives for the Management of Childhood Constipation - Cochrane for Clinicians - ...

Oct 1, 2017 - Polyethylene glycol (PEG) is superior to placebo (mean difference [MD] = 2.61 more stools per week; 95% confidence interval [CI], 1.15 to 4.08), lactulose (MD = 0.70; 95% CI, 0.10 to 1.31), and milk of magnesia (MD = 0.69; 95% CI, 0.48 to 0.89) at increasing the number of bowel ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/1001/p433.html

Lithium for Acute Mania - Cochrane for Clinicians - American Family Physician Restricted content. Login required.

May 1, 2020 - Lithium is more effective at inducing a reduction of at least 50% on the validated Young Mania Rating Scale compared with placebo (number needed to treat [NNT] = 6; 95% CI, 5 to 8; six studies; n = 1,707).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0501/p528.html

Low Glycemic Diets for Obesity Treatment - Cochrane for Clinicians - American Family ...

Jun 1, 2008 - Compared with high glycemic index diets or conventional energy-restricted weight loss diets, low glycemic index diets better reduce body mass index (BMI) and low-density lipoprotein (LDL) cholesterol. The weighted mean difference showed that patients lost an additional 1 to 2 BMI units ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0601/p1534.html

Low Glycemic Index Diets for the Management of Diabetes - Cochrane for Clinicians - ...

Nov 1, 2009 - The low glycemic index diet (sometimes called a low glycemic load diet) lowered the A1C level by a weighted mean difference of 0.5 percent when compared with a high glycemic index (or glycemic load) diet. Fewer episodes of hypoglycemia occurred with a low glycemic index diet compared ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/1101/p941.html

Low-Molecular-Weight Heparin for Initial Treatment of Venous Thromboembolism - Cochrane...

Jul 1, 2005 - LMWH is safer and more effective than unfractionated heparin for initial treatment of venous thromboembolism.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0701/p75.html

Magnesium Sulfate and Other Anticonvulsants for Women with Preeclampsia - Cochrane for ...

Jun 1, 2011 - Magnesium sulfate should be considered first-line treatment to prevent eclamptic seizures during labor.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0601/p1269.html

Magnesium Sulfate for Prevention of Preterm Birth - Cochrane for Clinicians - American ...

Apr 1, 2015 - Magnesium sulfate does not delay delivery when used in patients with preterm labor. Although magnesium sulfate is not associated with any serious adverse maternal outcomes, it may be associated with an increase in total fetal, neonatal, and infant mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0401/p444.html

Management of Constipation in Patients Receiving Palliative Care - Cochrane for ...

Dec 1, 2011 - There is insufficient evidence to recommend one laxative over another for the treatment of constipation in patients receiving palliative care. Methylnaltrexone can increase the frequency of bowel movements at four hours (odds ratio = 7.0; 95% confidence interval, 3.8 to 12.6) and at 24 ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/1201/p1227.html

Medical Management vs. Surgery for Gastroesophageal Reflux Disease - Cochrane for ...

Aug 1, 2010 - At one to three years, adults with GERD who were treated with laparoscopic fundoplication had more improvement in overall and GERD-specific quality of life scores and less exposure to acid in the lower esophagus compared with patients who use proton pump inhibitors (PPIs) and histamine ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0801/p244.html

Medical Treatments in the Short-term Management of Reflux Esophagitis - Cochrane for ...

Mar 1, 2008 - Proton pump inhibitors (PPIs) are the most effective short-term treatment for reflux esophagitis. Histamine H2 blockers are also effective compared with placebo, but are inferior to PPIs. There is limited evidence about adverse events with these therapies, but long-term therapy with ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0301/p620.html

Medication Management for Chronic Heart Failure with Preserved Ejection Fraction - ...

Jul 1, 2019 - Mineralocorticoid receptor antagonists reduce hospitalizations for patients with HFpEF. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have not been shown to change the morbidity or mortality in patients with HFpEF.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0701/p17.html

Methotrexate Therapy for Rheumatoid Arthritis - Cochrane for Clinicians - American ...

Jan 1, 2015 - Methotrexate monotherapy demonstrated statistically significant and clinically relevant improvement of symptoms and physical function compared with placebo at 12 to 52 weeks. Multiple adverse effects were reported with methotrexate use, and patients were twice as likely to discontinue ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0101/p26.html

Minocycline for Acne Vulgaris - Cochrane for Clinicians - American Family Physician

Sep 1, 2013 - Compared with placebo, minocycline generally improves acne, but it offers no clinical advantages over other therapies and has more serious adverse effects.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0901/p300.html

Misoprostol for Incomplete First Trimester Miscarriage - Cochrane for Clinicians - ...

Apr 1, 2014 - Misoprostol, administered by various routes, is as effective as expectant management and nearly as effective as uterine aspiration. All three options have high success rates for completing miscarriage. Women treated with misoprostol had higher rates of nausea, prolonged bleeding, and ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0401/p523.html

Music Therapy for Depression - Cochrane for Clinicians - American Family Physician Restricted content. Login required.

Mar 1, 2020 - Moderate-quality evidence shows that music therapy added to standard care is more effective in the first three months than standard care alone for depressive symptoms based on clinician-rated outcomes and patient-reported outcomes.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0301/p273.html

Neuraminidase Inhibitors for Influenza Treatment and Prevention in Healthy Adults - ...

Aug 1, 2010 - Although neuraminidase inhibitors can reduce the risk of contracting symptomatic, confirmed influenza and reduce the time to recovery for those with laboratory-confirmed influenza, they are not effective for reducing the risk of influenza-like illness or asymptomatic influenza infection...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0801/p242.html

Neuraminidase Inhibitors for Treatment of Influenza - Cochrane for Clinicians - ...

Jun 15, 2004 - Oseltamivir and zanamivir reduce the duration of illness by up to one day if taken within 36 hours of symptom onset. Oseltamivir (and, probably, zanamivir) also reduces the likelihood of otitis media as a complication of influenza (number needed to treat, approximately 10). There were ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/0615/p2824.html

Nicotine Receptor Partial Agonists for Smoking Cessation - Cochrane for Clinicians - ...

Oct 1, 2011 - Compared with placebo, varenicline more than doubles the chances of successful long-term smoking abstinence. In head-to-head trials, varenicline appears to be at least as effective as nicotine replacement therapy and bupropion (Zyban). The most common adverse effect is nausea, which ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/1001/p769.html

Nicotine Replacement Therapy for Smoking Cessation - Cochrane for Clinicians - American... Restricted content. Login required.

Jul 1, 2020 - Patients using a combination of nicotine patch and fast-acting NRT are more likely to quit smoking than those on any single therapy alone (number needed to treat [NNT] = 29; 95% CI, 20 to 47).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0701/p17.html

Nonpharmacologic vs. Anticholinergic Therapies for Overactive Bladder - Cochrane for ...

May 1, 2007 - Anticholinergic medications are more effective than bladder training in reducing the number of voids per day. Combining an anti-cholinergic medication with bladder training is more effective than either therapy alone.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0501/p1336.html

NSAIDs Alone or with Opioids as Therapy for Cancer Pain - Cochrane for Clinicians - ...

Aug 1, 2005 - Short-term trials indicate that cancer pain can be reduced with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) as initial monotherapy. NSAIDs combined with opioids can result in slight short-term improvement in pain compared with either agent alone. Long-term efficacy and ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0801/p436.html

NSAIDs vs. Opiates for Pain in Acute Renal Colic - Cochrane for Clinicians - American ...

Nov 1, 2004 - Data from randomized controlled trials comparing NSAIDs with opiates show that NSAIDs are associated with lower pain scores, less need for additional rescue medication, and less vomiting (particularly when compared with meperidine).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/1101/p1682.html

Occupational Therapy Improves Activities of Daily Living After Stroke - Cochrane for ...

Jun 1, 2007 - Compared with standard rehabilitation, ADL-based occupational therapy significantly decreases death or institutionalization and deterioration in the ability to perform ADL after stroke. The optimal length and type of therapy is not well defined.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0601/p1651.html

OnabotulinumtoxinA for Prevention of Migraine in Adults - Cochrane for Clinicians - ... Restricted content. Login required.

Feb 1, 2020 - OnabotulinumtoxinA reduces the number of migraine days per month by two days compared with placebo in adults with chronic migraines.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0201/p144.html

Opioid Antagonists for the Treatment of Alcohol Dependence - Cochrane for Clinicians - ...

Nov 1, 2011 - Although it does not improve overall alcohol abstinence rates, the oral formulation of the opioid antagonist naltrexone (Revia) is moderately effective in decreasing the amount and frequency of alcohol consumption in patients with alcohol dependence.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/1101/p990.html

Opioid Therapy for Chronic Noncancer Pain - Cochrane for Clinicians - American Family ...

Jul 1, 2010 - Weak evidence suggests that opioids reduce chronic noncancer pain in some highly selected patients, although the effects on quality of life and functional status are unclear.1 Many patients will discontinue opioids because of adverse effects or inadequate pain relief.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0701/p40.html

Opioids for Management of Breakthrough Pain in Cancer Patients - Cochrane for ...

Dec 1, 2006 - Oral transmucosal fentanyl citrate (OTFC [Actiq]), a rapid-acting opioid, has been shown to be an effective treatment for breakthrough cancer pain. Other opioids, including immediate-release oral morphine (MSIR), also may be effective; however, evidence comparing these agents with OTFC ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/1201/p1855.html

Opioids for Osteoarthritis of the Knee or Hip - Cochrane for Clinicians - American ...

May 1, 2010 - Compared with placebo, the benefits achieved from opioid therapy are modest in terms of pain relief and improvement in function, and do not outweigh the increase in adverse effects. No single opioid stands out as more effective or safer than the rest.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0501/p1094.html

Optimal Antibiotic Regimen for Treating Lower UTI in Children - Cochrane for Clinicians...

Nov 1, 2013 - For the afebrile child with a UTI, a short course (three to seven days) of antibiotics is as effective at preventing the recurrence of symptomatic UTI as a long course (seven to 10 days). There is no clear evidence of superiority for any one antibiotic regimen.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/1101/p577.html

Optimal Dosage of Tricyclic Antidepressants - Cochrane for Clinicians - American Family...

Oct 1, 2004 - Although the quality of the data limits the strength of the recommendation, current evidence shows that 75 to 100 mg per day of a tricyclic antidepressant is more effective than placebo. Higher dosages are not more effective and are associated with more dropouts because of side effects.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/1001/p1270.html

Optimal Duration of Treatment Regimens for H. pylori Eradication - Cochrane for ...

Dec 1, 2014 - When using proton pump inhibitor (PPI) triple therapy, increasing the duration of treatment from seven to 10 days or from 10 to 14 days significantly increases the eradication of H. pylori. When using other treatment regimens, it is unclear whether increasing duration of treatment ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/1201/p766.html

Oral Anticoagulants vs. Antiplatelet Therapy - Cochrane for Clinicians - American ...

May 1, 2008 - Compared with antiplatelet therapy, oral anticoagulation significantly reduces stroke at an average follow-up of one to three years, but does not reduce mortality. Intracranial or extracranial hemorrhage is more common with anticoagulation and must be weighed against its therapeutic ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0501/p1250.html

Oral Antihistamine/Decongestant/Analgesic Combinations for the Common Cold - Cochrane ...

Nov 1, 2012 - Combination cold medications, including antihistamine/decongestant/analgesic, antihistamine/decongestant, antihistamine/analgesic, and analgesic/decongestant formulations, provide modest symptom relief in adults and older children, but are not effective in young children. Only the ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/1101/p812.html

Oral Appliances for Obstructive Sleep Apnea? - Cochrane for Clinicians - American ...

Mar 1, 2006 - Although oral appliances provide improved subjective sleepiness and sleep-disordered breathing, continuous positive airway pressure (CPAP) is more effective. Oral appliances should not be used as a first-line treatment but rather should be reserved for patients who cannot tolerate CPAP ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0301/p801.html

Oral Contraceptives Are Not an Effective Treatment for Ovarian Cysts - Cochrane for ...

Nov 1, 2014 - Oral contraceptives are not an effective treatment for ovarian cysts, whether the cysts are spontaneous or associated with medically induced ovulation. Most cysts resolve without intervention within two to three months. Those that do not resolve in this time frame are more likely to be ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/1101/p623.html

Oral H1 Antihistamines as Add-on Therapy to Topical Treatment for Eczema - Cochrane for... Restricted content. Login required.

Nov 1, 2019 - In children with eczema, there is no evidence to support the addition of oral H1 antihistamines to standard treatment regimens. In adults, the use of fexofenadine (Allegra), 120 mg per day, improves patient-assessed eczema symptoms compared with placebo (number needed to treat = 11; 95%...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/1101/p541.html

Oral Immunotherapy for Egg Allergy - Cochrane for Clinicians - American Family Physician

Feb 1, 2019 - Providing daily, steadily increasing doses of egg protein over an extended period of time effectively diminishes the immunoglobulin E (IgE)-mediated allergic response among children with egg allergy.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0201/p156.html

Over-the-Counter Medications for Acute Cough Symptoms - Cochrane for Clinicians - ...

Jul 1, 2008 - It is uncertain whether OTC cough medications are effective in reducing cough symptoms in adults; in children, no trials show a statistically significant benefit in the treatment compared with the placebo groups. Overall, the quality of evidence is poor; adult studies show conflicting ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0701/p52.html

Oxytocin Augmentation During Labor with Epidural Analgesia - Cochrane for Clinicians - ...

Jun 1, 2013 - Oxytocin augmentation does not reduce the frequency of cesarean delivery, instrumental vaginal delivery, or the combined outcome of both. Oxytocin also has no effect on low five-minute Apgar scores, postpartum hemorrhage, uterine hyperstimulation, or neonatal intensive care unit ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0601/p760.html

Patching for Corneal Abrasions? - Cochrane for Clinicians - American Family Physician

Dec 1, 2006 - Patching is not beneficial for the treatment of simple corneal abrasions as measured by time to healing, complete healing rates at 24 to 48 hours, or pain.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/1201/p1857.html

Patient-Controlled Analgesia for Postoperative Pain - Cochrane for Clinicians - ...

Dec 1, 2007 - Patient-controlled opioid analgesia is safe and provides a statistically significant improvement in analgesia in postoperative patients, but the clinical significance of the improvement is marginal.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/1201/p1645.html

Pelvic Floor Muscle Training vs. Control for Urinary Incontinence in Women - Cochrane ... Restricted content. Login required.

Apr 1, 2020 - Use of pelvic floor muscle training to treat women with all subtypes of urinary incontinence results in improvement or cure vs. no treatment (number needed to treat [NNT] = 2.5; 95% CI, 1.4 to 5.4). Treatment with pelvic floor muscle training also results in one fewer episode of leakage...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0401/p393.html

Pharmacologic Cardioversion for Atrial Fibrillation and Flutter - Cochrane for ...

Dec 1, 2005 - There is no evidence that rhythm control in older patients with atrial fibrillation is more effective than rate control for improving patient-oriented outcomes.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/1201/p2217.html

Pharmacologic Interventions for Apathy in Patients with Alzheimer Disease - Cochrane ...

Jan 1, 2019 - Methylphenidate may improve apathy in select patients with AD (mean difference [MD] = –4.99 on the apathy evaluation scale; 95% confidence interval [CI], –9.55 to –0.43), although the clinical significance associated with these findings remains unclear and the evidence is considered low...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0101/p14.html

Pharmacologic Therapy for Gastroesophageal Reflux Disease in Children - Cochrane for ...

Sep 1, 2015 - Among infants younger than 12 months diagnosed with GERD, weak evidence supports the use of proton pump inhibitors (PPIs) and histamine H2 antagonists. Among children 12 months and older, studies have shown moderate benefit from PPIs and weak benefit from H2 antagonists for providing ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0901/p351.html

Pharmacotherapy for Mild Hypertension - Cochrane for Clinicians - American Family ...

Jul 1, 2013 - Pharmacologic treatment of mild hypertension for up to five years does not reduce coronary events, stroke, or mortality compared with placebo.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0701/p21.html

Physical Fitness Training for Patients with Stroke - Cochrane for Clinicians - American...

Jun 1, 2017 - There is moderate-quality evidence that physical fitness training improves disability after stroke. Cardiovascular training that includes only aerobic exercise has a moderate effect on disability (standard mean difference [SMD] = 0.52 on a pooled disability scale), although it is not ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0601/p701.html

Physical Training for Patients with Asthma - Cochrane for Clinicians - American Family ...

Mar 1, 2013 - Physical training lasting for at least 20 to 30 minutes, two to three times a week for at least six weeks, improves physical fitness in patients with asthma. Physical training is not associated with worsening of asthma symptoms, and it improves health-related quality of life.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0301/p313.html

Pilates for the Treatment of Low Back Pain - Cochrane for Clinicians - American Family ...

Apr 1, 2016 - There is low- to moderate-quality evidence that Pilates exercises taught by certified instructors improve pain and reduce disability in patients with chronic low back pain. It is unclear whether a Pilates regimen is superior to other exercise plans for the treatment of low back pain. ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/0401/p556.html

Point-of-Care C-Reactive Protein Testing to Help Guide Treatment of Acute Respiratory ...

Oct 1, 2015 - Point-of-care C-reactive protein (CRP) testing used as an adjunct to a physician's clinical examination can modestly reduce antibiotic use. Measurement of CRP to guide antibiotic prescription does not appear to affect the duration of illness or recovery, although one study suggests that...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/1001/p571.html

Positional Therapy for Obstructive Sleep Apnea - Cochrane for Clinicians - American ... Restricted content. Login required.

Jan 1, 2020 - Positional therapy for OSA reduces scores on the apnea-hypopnea index (AHI) and Epworth Sleepiness Scale compared with no treatment. Although continuous positive airway pressure (CPAP) improves AHI scores more than positional therapy, patients seem to better tolerate positional therapy ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0101/p16.html

Pregabalin for Fibromyalgia Pain in Adults - Cochrane for Clinicians - American Family ...

Sep 1, 2017 - There is high-quality evidence that pregabalin in daily dosages of 300 mg, 450 mg, and 600 mg reduces pain associated with fibromyalgia. The most effective dosage seems to be 450 mg daily; this dosage is more effective than placebo at reducing pain by at least 50% (number needed to ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0901/p291.html

Preoperative Testing for Patients Undergoing Cataract Surgery - Cochrane for Clinicians...

Dec 1, 2009 - Routine preoperative testing before cataract surgery does not reduce intraoperative or postoperative complications.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/1201/p1228.html

Probiotics for Persistent Diarrhea in Children - Cochrane for Clinicians - American ...

Jul 1, 2011 - Limited data suggest that probiotic use decreases duration and frequency of loose stools, and reduces length of hospital stay in children with persistent diarrhea. One high-quality study showed Lactobacillus rhamnosus GG to be effective. Probiotics are generally well tolerated.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0701/p25.html

Procalcitonin to Guide Antibiotic Therapy in Acute Respiratory Infections - Cochrane ...

Jul 1, 2018 - Procalcitonin-guided antibiotic therapy, when compared with routine treatments, results in decreased mortality in patients with acute respiratory infections (absolute risk reduction [ARR] = 1.4%; number needed to treat [NNT] = 71).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2018/0701/p20.html

Prophylactic Antibiotics for the Prevention of COPD Exacerbation - Cochrane for ...

Jun 1, 2014 - Continuous prophylactic antibiotic therapy significantly decreases COPD exacerbations for up to three years. However, it does not decrease mortality, and it puts the patient at risk of antibiotic-resistant colonization and infection.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0601/p870.html

Psychological Interventions for Medically Unexplained Physical Symptoms - Cochrane for ...

Dec 1, 2015 - Psychological therapy, specifically cognitive behavior therapy (CBT), has been shown to reduce the severity of medically unexplained physical symptoms in patients with somatoform disorders. The effect is small to moderate in magnitude, but in these studies CBT was as acceptable as usual...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/1201/p975.html

Psychological Interventions for Noncardiac Chest Pain - Cochrane for Clinicians - ...

Nov 1, 2005 - Noncardiac chest pain can be caused by gastroesophageal reflux disease (GERD), panic disorder, or a number of other psychological conditions. Psychotherapy, particularly cognitive behavior therapy, has been shown to reduce the number of days with chest pain significantly over a ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/1101/p1701.html

Psychological Therapies for Chronic Posttraumatic Stress Disorder - Cochrane for ...

Oct 1, 2014 - Trauma-focused cognitive behavior therapy (CBT) and eye movement desensitization and reprocessing (EMDR) are more effective than other therapies in reducing PTSD symptom severity up to four months after treatment, but more robust studies are needed to evaluate the long-term effectiveness.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/1001/p454.html

Quinine for Leg Cramps - Cochrane for Clinicians - American Family Physician

Feb 1, 2016 - Quinine is moderately effective in decreasing the frequency and intensity of muscle cramps, but it is also associated with an increase in minor adverse effects. In addition, there is a risk of rare but serious adverse effects.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/0201/p177.html

Radioactive Iodine Therapy vs. Antithyroid Medications for Graves Disease - Cochrane ...

Mar 1, 2017 - Radioactive iodine therapy and antithyroid medications produce similar health-related quality-of-life outcomes in patients with Graves disease. Radioactive iodine therapy is an appropriate choice for patients who prefer definitive treatment.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0301/p292.html

Renin-Angiotensin System Inhibitors vs. Other Antihypertensive Drug Classes for ... Restricted content. Login required.

Nov 1, 2019 - RAS inhibitors, which include angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, and renin inhibitors, should not be used as first-line agents.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/1101/p540.html

Risk of Venous Thromboembolism with Use of Combined Oral Contraceptives - Cochrane for ...

Mar 1, 2015 - All combined oral contraceptives increase VTE risk. The risk is greater for those containing desogestrel, drospirenone, gestodene (not available in the United States), and cyproterone acetate (not available in the United States) when compared with levonorgestrel. All combined oral ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0301/p287.html

Risperidone vs. Placebo for Schizophrenia - Cochrane for Clinicians - American Family ...

May 1, 2010 - Compared with placebo, risperidone improves symptoms based on some disease-specific symptom scores for schizophrenia. However, it does not appear to improve symptoms on a more important Clinical Global Impression scale.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0501/p1096.html

Role of Breathing Exercises in the Treatment of COPD - Cochrane for Clinicians - ...

Jan 1, 2014 - Patients with COPD who are treated with breathing exercises vs. standard care showed an improvement in exercise capacity, with inconsistent changes in dyspnea and health-related quality of life. Adding breathing exercises to a pulmonary rehabilitation program did not show any increased ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0101/p15.html

Role of Mucolytics in the Treatment of Chronic Bronchitis or COPD - Cochrane for ... Restricted content. Login required.

Jul 1, 2020 - Oral mucolytic agents may reduce the number of acute exacerbations in patients with chronic bronchitis or COPD (number needed to treat [NNT] = 8 over an average of nine months; 95% CI, 7 to 10).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0701/p16.html

Room Air vs. Oxygen for Resuscitating Infants at Birth - Cochrane for Clinicians - ...

Sep 1, 2005 - Based on limited evidence, it appears that mortality is lower in infants resuscitated with room air than in those given 100 percent oxygen. However, these results should be treated with caution because one fourth of studies used back-up supplementary oxygen.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0901/p808.html

Safety of Long-Acting Beta Agonists in Adults with Asthma - Cochrane for Clinicians - ...

Oct 1, 2014 - LABAs appear to be safe when used with inhaled corticosteroids. LABA monotherapy is associated with an increase in asthma-related mortality and nonfatal serious adverse events, but not in all-cause mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/1001/p453.html

Saline Irrigation for Allergic Rhinitis - Cochrane for Clinicians - American Family ...

May 1, 2019 - asal saline irrigation reduces the severity of allergy symptoms for up to eight weeks vs. no treatment. It is uncertain if adding nasal saline to pharmacologic treatment further improves symptoms over pharmacologic treatment alone.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0501/p544.html

Same-Day Initiation of Hormonal Contraceptives - Cochrane for Clinicians - American ...

Oct 1, 2009 - Giving an injection of medroxyprogesterone (Depo-Provera) on any day of a patient's menstrual cycle decreases unintended pregnancies. For other hormonal methods, there is limited evidence. Compared with deferring until the patient's next menses, immediate start of hormonal methods ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/1001/p690.html

Second-Generation H1-Antihistamines for Chronic Spontaneous Urticaria - Cochrane for ...

Sep 1, 2016 - There is good evidence that second-generation H1-antihistamines are helpful in the short- and intermediate-term suppression of urticaria. Cetirizine (Zyrtec) in a dosage of 10 mg daily is effective at completely suppressing symptoms of chronic spontaneous urticaria (number needed to ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/0901/p352.html

Selective Serotonin Reuptake Inhibitors for Fibromyalgia - Cochrane for Clinicians - ...

Oct 1, 2016 - SSRIs may have a small to moderate effect on pain (number needed to treat [NNT] = 10), global improvement (NNT = 7), and depression (NNT = 13) in patients with fibromyalgia, but the quality of evidence is very low because of bias and small studies. SSRIs do not reduce fatigue related to...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/1001/p548.html

Self-Monitoring and Self-Management of Oral Anticoagulation - Cochrane for Clinicians -...

Jun 1, 2017 - In patients taking warfarin (Coumadin) for anticoagulation, there is moderate-quality evidence that both self-monitoring (number needed to treat [NNT] = 100) and self-management (NNT = 53) reduce thromboembolic events, and that self-management reduces all-cause mortality (NNT = 67).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0601/p700.html

Self-Monitoring of Blood Glucose in Patients with Type 2 Diabetes Not Using Insulin - ...

May 1, 2012 - For patients who have had diabetes longer than one year and are not using insulin, evidence suggests that the benefit of self-monitoring of blood glucose in lowering A1C levels is small at six months and disappears by 12 months. Self-monitoring of blood glucose does not improve ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0501/p866.html

Short Course of Antibiotics for Acute Otitis Media Treatment - Cochrane for Clinicians ...

Jan 1, 2011 - Antibiotic courses between two and seven days in duration are associated with a slightly higher risk of treatment failure than longer courses (number needed to treat = 33), but also a somewhat lower risk of adverse gastrointestinal effects (number needed to harm = 29). Ceftriaxone ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0101/p37.html

Short-Acting Insulin Analogues vs. Human Insulin for Diabetes - Cochrane for Clinicians...

Sep 1, 2005 - For patients with type 2 diabetes, regular insulin and short-acting insulin analogues are equally effective in the treatment of diabetes and in lowering A1C levels. For patients with type 1 diabetes, short-acting analogues produce a slightly greater reduction of A1C levels than regular ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0901/p805.html

Should Salmeterol Be Used for Long-Term Asthma Control? - Cochrane for Clinicians - ...

Jun 1, 2009 - Salmeterol may help improve asthma symptoms, but it should only be used as part of a comprehensive asthma management plan including inhaled corticosteroids and a short-acting beta agonist. There is currently insufficient evidence to confirm that salmeterol does not increase the risk of ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0601/p957.html

Should We Prescribe Antibiotics for Acute Bronchitis? - Cochrane for Clinicians - ...

Jul 1, 2001 - While there is evidence that antibiotics offer a slight benefit to patients with acute bronchitis, there is not a compelling reason to treat this patient with antibiotics.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2001/0701/p135.html

Should We Prescribe Antibiotics for Acute Conjunctivitis? - Cochrane for Clinicians - ...

Nov 1, 2002 - This review indicates that even in high-risk patients with bacterial conjunctivitis, there is only a small benefit of treatment with antibiotics. Furthermore, most cases (64 percent) resolve spontaneously, and complications are rare. Therefore, it is reasonable to avoid antibiotic use ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2002/1101/p1649.html

Should We Prescribe Antibiotics for Acute Otitis Media? - Cochrane for Clinicians - ...

Aug 1, 2001 - Based on this review and the systematic reviews of Rosenfeld and Kozyrskyj, antibiotics appear to play a small but potentially useful role in the treatment of acute otitis media in children. Antibiotics produce a reduction in pain at two to seven days but have no effect on tympanometry,...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2001/0801/p469.html

Should We Recommend Nicotine Replacement Therapy? - Cochrane for Clinicians - American ...

Jun 1, 2001 - Yes. The patient is highly nicotine-dependent, and for smokers with moderate to severe nicotine dependence, nicotine replacement therapy with or without bupropion should be offered as part of an intensive program of physician advice, counseling and follow-up. This answer is based on an ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2001/0601/p2245.html

Smectite for Acute Infectious Diarrhea in Children - Cochrane for Clinicians - American...

Mar 1, 2019 - When compared with placebo, smectite decreases the duration of diarrhea by about a day, with a mean difference of 24.4 fewer hours of diarrhea (95% confidence interval [CI], 17.9 to 30.9 hours). Smectite also decreases stool output by 11.4 g per kg (95% CI, 0.8 to 22 g per kg).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0301/p294.html

Smoking Cessation with Text Messaging and App-Based Interventions - Cochrane for ... Restricted content. Login required.

Aug 1, 2020 - Automated text messaging interventions are more effective than minimal smoking cessation support (absolute risk reduction [ARR] = 3%; 95% CI, 1% to 5%).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0801/p148.html

Spinal Manipulative Therapy for Low Back Pain - Cochrane for Clinicians - American ...

Feb 1, 2005 - In the short term, manipulative therapy is as effective for acute or chronic low back pain as other treatments such as analgesics, physical therapy, exercises, back school, and routine care from a primary care physician. Radiation of pain, type of manipulation, and use of multiple ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0201/p464.html

Stage-Based Interventions for Smoking Cessation - Cochrane for Clinicians - American ...

Mar 1, 2011 - Although providing stage-based smoking cessation interventions for those trying to quit appears to be more effective than not intervening at all, the evidence does not support tailoring interventions to a patient's perceived motivational stage of change.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0301/p524.html

Statins for Non-Dialysis Chronic Kidney Disease - Cochrane for Clinicians - American ...

Jan 1, 2010 - When taken over a five-year period, statins significantly reduce all-cause mortality (number needed to treat [NNT] = 56), cardiovascular mortality (NNT = 86), and nonfatal cardiovascular events (NNT = 25).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0101/p27.html

Steroids for the Treatment of Otitis Media with Effusion in Children - Cochrane for ...

Feb 1, 2012 - Oral steroid use, alone or in combination with antibiotics, speeds the resolution of otitis media with effusion. However, there is no evidence that oral steroids improve symptoms or affect long-term outcomes, such as hearing loss. Topical nasal steroids have no effect on otitis media ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0201/p235.html

Subclinical Hypothyroidism - Cochrane for Clinicians - American Family Physician

Apr 1, 2008 - Although there is evidence that thyroid hormone therapy in patients with subclinical hypothyroidism may improve lipid profiles, cognitive function, and echographic left ventricular function, there is no evidence that this will decrease morbidity or mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0401/p953.html

Surgery vs. Medical Therapy for Heavy Menstrual Bleeding - Cochrane for Clinicians - ...

Jul 1, 2017 - In women of reproductive age with chronic heavy menstrual bleeding, hysterectomy is the most effective treatment for controlling symptoms. Conservative surgery is more effective for controlling bleeding symptoms at one and two years than oral medications or the levonorgestrel-releasing ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0701/p24.html

Symptomatic Treatment and H. pylori Eradication Therapy for Nonulcer Dyspepsia - ...

Nov 1, 2001 - Bismuth subcitrate, histamine H2-receptor antagonists or proton pump inhibitors could be recommended for short-term relief of symptoms. Eradication of H. pylori would slightly decrease this patient's chance of having persistent symptoms over the next three to 12 months.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2001/1101/p1605.html

Systemic Corticosteroids for Acute Exacerbations of COPD - Cochrane for Clinicians - ...

Aug 1, 2005 - Systemic corticosteroids improve symptoms of acute COPD exacerbations at three days and reduce the likelihood of treatment failure. There is no evidence that they reduce mortality or prevent recurrence at 30 days, but the existing studies may be too small to detect such a benefit. ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0801/p437.html

Tegaserod in Patients with Irritable Bowel Syndrome - Cochrane for Clinicians - ...

Dec 1, 2004 - Tegaserod offers modest improvement in global gastrointestinal (GI) symptoms in women with constipation-predominant IBS, without having significant effect on symptoms of abdominal pain and discomfort.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/1201/p2107.html

Telephone Counseling Improves Smoking Cessation Rates - Cochrane for Clinicians - ...

Mar 1, 2007 - Telephone counseling can improve long-term smoking cessation rates. Multiple proactive calls are more effective than a single reactive call.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0301/p650.html

The Effects of Combination Contraceptives on Weight - Cochrane for Clinicians - ...

Dec 1, 2012 - Compared with placebo or no intervention, the use of combination contraceptives was not associated with weight gain. Most studies comparing different types of combination contraceptives showed no statistically significant effects on weight.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/1201/p1009.html

The Epley Maneuver for Treatment of Benign Paroxysmal Positional Vertigo - Cochrane for...

Aug 1, 2015 - Treatment with the Epley maneuver resolves benign paroxysmal positional vertigo better than sham therapy or control. Minor adverse effects are uncommon.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0801/p184.html

The Impact of Contraception on Lactation - Cochrane for Clinicians - American Family ...

Mar 1, 2016 - Use of hormonal contraception does not appear to shorten breastfeeding duration or negatively impact infant growth, based on inconsistent evidence of moderate quality. It is unclear if hormonal contraception negatively impacts breast milk volume or composition. Overall, there was ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/0301/p356.html

The Role of Exercise in Patients with Type 2 Diabetes - Cochrane for Clinicians - ...

Feb 1, 2007 - Regular exercise reduces A1C levels, adiposity, and triglyceride levels. However, no research has definitively proved a benefit of exercise on patient-oriented outcomes such as diabetes-related morbidity and mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0201/p335.html

The Role of Levetiracetam in Treating Chronic Neuropathic Pain Symptoms - Cochrane for ...

Jul 1, 2015 - Based on low-quality evidence, levetiracetam was found to be ineffective for the treatment of chronic neuropathic pain symptoms. Moreover, patients who were taking levetiracetam experienced adverse effects at a significantly higher rate than those who were taking placebo.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0701/p23.html

The Role of Proton Pump Inhibitor Therapy in Patients with Functional Dyspepsia - ...

Aug 1, 2018 - There is moderate-quality evidence that PPIs are more effective than placebo at relieving overall symptoms in patients with functional dyspepsia (number needed to treat [NNT] = 11). Low-quality evidence suggests a small benefit of PPI therapy compared with prokinetics, and little to no ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2018/0801/p152.html

Therapist-Supported Online Cognitive Behavior Therapy for Adult Anxiety - Cochrane for ...

Jan 1, 2016 - Therapist-supported online CBT is more effective than no treatment and as effective as face-to-face CBT for reducing overall anxiety as well as symptoms, and improving quality of life in adults with anxiety disorders.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/0101/p19.html

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