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Abstinence-Plus Programs for Prevention of HIV - Cochrane for Clinicians - American ...

Apr 1, 2008 - Abstinence-plus is sex education that includes information on abstinence, condom use, and contraception. Compared with a variety of controls—including usual care, no intervention, or other programs—there is no evidence of increased rates of pregnancy or sexually transmitted infection ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0401/p955.html

Accuracy of Dermoscopy vs. Visual Inspection for Diagnosing Melanoma in Adults - ... Restricted content. Login required.

Feb 1, 2020 - The addition of dermoscopy to in-person visual inspection of skin lesions increases specificity and sensitivity in the detection of melanoma. In-person evaluation with dermoscopy is more accurate than image-based assessment.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0201/p145.html

ACE Inhibitors vs. ARBs for Patients with Diabetic Kidney Disease - Cochrane for ...

Jul 1, 2007 - Studies comparing ACE inhibitors or ARBs with placebo found no mortality benefit in patients with diabetic kidney disease. A subgroup analysis of five studies (2,034 total patients) found that, when given at full or maximally tolerated doses, ACE inhibitors reduce all-cause mortality ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0701/p68.html

ACE Inhibitors vs. ARBs for Primary Hypertension - Cochrane for Clinicians - American ...

Apr 15, 2015 - ACE inhibitors and ARBs have similar effects on cardiovascular outcomes and total mortality in head-to-head trials. However, slightly more adverse effects were noted in patients assigned to ACE inhibitor therapy.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0415/p522.html

Acellular Vaccines for Preventing Pertussis in Children - Cochrane for Clinicians - ...

Sep 1, 2011 - Multicomponent (i.e., three or more) acellular vaccines are as effective as whole-cell vaccines at preventing pertussis and mild pertussis disease (e.g., cold symptoms, cough without classic whoop or cough paroxysms) in children. Adverse effects are similar to those from placebo and ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0901/p504.html

Acetaminophen for the Treatment of Pain in Newborns - Cochrane for Clinicians - ...

Aug 1, 2016 - Acetaminophen does not significantly reduce pain associated with heel lance, eye examinations, or assisted vaginal births in newborns. Acetaminophen may reduce the total amount of morphine a newborn needs in the first 48 hours following major abdominal or thoracic surgery.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/0801/p216.html

Aclidinium for Stable COPD - Cochrane for Clinicians - American Family Physician

Jun 1, 2015 - Aclidinium did not decrease all-cause mortality or exacerbations requiring oral steroids, antibiotics, or both. However, aclidinium decreased the number of patients with exacerbations requiring hospitalization and improved quality of life in those with stable COPD.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0601/p760.html

Acupuncture for Migraine Prevention - Cochrane for Clinicians - American Family Physician

Jul 1, 2017 - There is moderate-quality evidence that whole-body acupuncture is effective for migraine prevention. Compared with usual care, acupuncture is more effective at reducing headache frequency by at least 50% (number needed to treat [NNT] = 4).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0701/p23.html

Acute Treatment of Hyperkalemia - Cochrane for Clinicians - American Family Physician

Nov 1, 2005 - According to disease-oriented evidence, insulin and intravenous glucose, inhaled albuterol (Ventolin), and dialysis are the best treatment options; the first two may be given in combination. Bicarbonate or resins are not recommended for routine use, particularly without one of the more ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/1101/p1703.html

Addition of Long-Acting Beta Agonists for Asthma in Children - Cochrane for Clinicians ...

Mar 1, 2010 - In children with persistent asthma who are already taking inhaled corticosteroids, the addition of a LABA does not lower the rate of exacerbations requiring oral steroids, rescue medication, or hospitalizations, but it improves measurable lung function.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0301/p598.html

Adenosine vs. Calcium Channel Blockers for Supraventricular Tachycardia - Cochrane for ...

Jun 1, 2007 - Adenosine and verapamil (Calan, Isoptin SR) are equally effective for treating acute supra-ventricular tachycardia in adults. Patients treated with adenosine have a higher rate of minor, transient adverse effects than patients treated with verapamil; however, rare but serious adverse ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0601/p1653.html

Advance Provision for Emergency Oral Contraception - Cochrane for Clinicians - American...

Sep 1, 2007 - Providing oral emergency contraceptives in advance to fertile women for use after unprotected sexual intercourse (i.e., advance provision) does not affect pregnancy rates, condom use, sexually transmitted infection rates, or type of contraception used. Advance provision more than ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0901/p654.html

Aerobic Activity for Cognitive Function - Cochrane for Clinicians - American Family ...

Apr 1, 2009 - Physical activity improves cardiovascular fitness in persons older than 55 years. Cognitive speed and auditory and visual attention are increased in healthy older adults who exercise.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0401/p562.html

Alendronate for Fracture Prevention in Postmenopause - Cochrane for Clinicians - ...

Sep 1, 2008 - In postmenopausal women, a 10-mg daily dose of alendronate is effective for secondary (number needed to treat [NNT] = 16) and primary (NNT = 50) prevention of vertebral fractures. It is also effective for secondary prevention of nonvertebral fractures, including hip or wrist fractures ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0901/p579.html

Alpha Blockers to Speed Ureteral Stone Passage - Cochrane for Clinicians - American ...

Feb 1, 2015 - Compared with patients receiving standard therapy (e.g., fluids, analgesics), placebo, or calcium channel blockers, patients receiving alpha blockers had about three fewer days to ureteral stone expulsion and were less likely to be hospitalized. Adverse effects of alpha blocker therapy ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0201/p164.html

Alpha-glucosidase Inhibitors May Reduce the Risk of Type 2 Diabetes - Cochrane for ...

Aug 1, 2007 - The literature shows that acarbose can reduce the risk of type 2 diabetes in patients with impaired glucose tolerance or impaired fasting glucose. However, it is unclear whether the drug stops or delays the development of the disease or masks the diagnosis. There is no evidence that ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0801/p374.html

Alternative Interventions for Chronic Prostatitis/Chronic Pelvic Pain Syndrome in Men -...

Jun 1, 2019 - In men with chronic pelvic pain and urinary dysfunction who have not responded to standard medical management, extracorporeal shock wave therapy reduces symptoms and increases quality of life. Acupuncture may also provide benefit to some patients.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0601/p677.html

Amiodarone for the Prevention of Sudden Cardiac Death - Cochrane for Clinicians - ...

Nov 1, 2016 - Although not a substitute for an implantable cardioverter-defibrillator (ICD), amiodarone is effective for the primary prevention of sudden cardiac death when compared with placebo (number needed to treat [NNT] = 47; 95% confidence interval [CI], 33 to 100), but it does not ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/1101/p692.html

Amphetamines for Attention-Deficit/Hyperactivity Disorder in Adults - Cochrane for ...

Sep 1, 2012 - Amphetamines improve ADHD symptom severity but, when compared with placebo, they are associated with increased discontinuation rates because of adverse effects. There does not appear to be a difference among dosages or between the immediate- and sustained-release formulations.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0901/p413.html

Antenatal Perineal Massage to Prevent Birth Trauma - Cochrane for Clinicians - American...

Mar 1, 2014 - Antenatal digital perineal massage in the final month of pregnancy is safe and well tolerated. Women who have not had a previous vaginal delivery and perform digital perineal massage in the final month of pregnancy experience less perineal birth trauma, mostly through fewer ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0301/p335.html

Antepartum Omega-3 Fatty Acid Intake and Length of Gestation - Cochrane for Clinicians ... Restricted content. Login required.

Jan 1, 2020 - Omega-3 fatty acids, whether taken as supplements or consumed as part of the diet, reduce the risk of preterm birth (number needed to treat = 68) and early preterm birth (number needed to treat = 55).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0101/p17.html

Antibiotics for Acute Laryngitis in Adults - Cochrane for Clinicians - American Family ...

Jul 1, 2005 - Two small trials of antibiotic treatment in acute laryngitis do not support routine use of antibiotics in these patients. Most patients will feel better in five to seven days, and it is unlikely that they will experience a clinically important benefit from antibiotics.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0701/p76.html

Antibiotics for Acute Maxillary Sinusitis - Cochrane for Clinicians - American Family ...

May 1, 2009 - Although there is some evidence that antibiotics are effective in the treatment of acute uncomplicated sinusitis, this benefit is modest. Most patients with acute sinusitis improve within two weeks without antibiotics. The potential risk of adverse effects from antibiotics may outweigh ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0501/p757.html

Antibiotics for Exacerbations of COPD - Cochrane for Clinicians - American Family ...

Sep 1, 2006 - There is consistent evidence from a small number of studies that antibiotics significantly reduce mortality (number needed to treat [NNT] = 8) and treatment failure (NNT = 3) in more severely ill patients with COPD who are hospitalized because of an exacerbation. Two smaller studies ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0901/p749.html

Antibiotics for Recurrent Urinary Tract Infections - Cochrane for Clinicians - American...

Apr 1, 2005 - Prophylactic antibiotics can reduce the number of recurrent UTIs in nonpregnant women while they are taking the medication (relative risk [RR], 0.21; number needed to treat [NNT], 2). No antibiotic was significantly better than others at decreasing the number of UTIs, and all ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0401/p1301.html

Antibiotics for Sore Throat - Cochrane for Clinicians - American Family Physician

Jul 1, 2014 - Compared with placebo, antibiotics can shorten the duration of sore throat symptoms by about 16 hours and can reduce complications. In countries where the absolute rates of complications are higher, antibiotic therapy is more likely to be effective. The effectiveness of antibiotic ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0701/p23.html

Anticholinergic Drugs for Overactive Bladder - Cochrane for Clinicians - American ...

Jan 1, 2006 - Tolterodine (Detrol) is as effective as immediate-release oxybutynin (Ditropan) and causes less dry mouth. A dose of 1 mg tolterodine twice daily is as effective as higher dosages of tolterodine. Extended-release preparations have less risk of dry mouth but are more expensive.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0101/p66.html

Anticoagulation for the Long-term Treatment of VTE in Patients with Cancer - Cochrane ...

Jun 1, 2019 - Low-molecular-weight heparin (LMWH), vitamin K antagonists, and direct oral anticoagulants, when used to prevent recurrent VTE, have a similar impact on all-cause mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0601/p676.html

Anticoagulation for the Long-term Treatment of VTE in Patients with Cancer - Cochrane ...

Jul 1, 2009 - Although LMWH appears to be more effective than oral anticoagulants in the prevention of recurrent VTE, this does not translate into a survival benefit. LMWH and oral anticoagulants have the same reported adverse events of bleeding and thrombocytopenia.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0701/p30.html

Anticonvulsant Medications for Migraine Prevention - Cochrane for Clinicians - American...

May 1, 2005 - Good evidence supports the use of anticonvulsants as a class with overall reduction in number of headaches per month and overall increase in patients achieving 50 percent reduction of headache frequency. Of the medications within this heterogeneous group, valproic acid and divalproex ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0501/p1699.html

Antidepressants and Smoking Cessation - Cochrane for Clinicians - American Family ...

Jan 1, 2005 - Bupropion and nortriptyline increase the likelihood of smoking cessation, but selective serotonin reuptake inhibitors (SSRIs) do not.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0101/p67.html

Antidepressants for Agitation and Psychosis in Patients with Dementia - Cochrane for ...

Jan 1, 2012 - There are few high-quality studies examining the effectiveness of antidepressants for treating the neuropsychiatric symptoms of dementia. Although there is some evidence to support the use of the selective serotonin reuptake inhibitors (SSRIs) sertraline (Zoloft) and citalopram ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0101/p20.html

Antidepressants for Generalized Anxiety Disorder - Cochrane for Clinicians - American ...

Nov 1, 2003 - As a group, antidepressants are an effective short-term treatment for GAD. Compared with placebo, about five to six patients must be treated to get one additional patient who responds to therapy. Side effects occur more frequently with antidepressants than with placebo, but they are not...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2003/1101/p1757.html

Antidepressants for the Treatment of Neuropathic Pain - Cochrane for Clinicians - ...

Jun 1, 2006 - Tricyclic antidepressants, particularly amitriptyline, are effective for the treatment of painful diabetic neuropathy and post herpetic neuralgia, and may be beneficial in other neuropathic pain syndromes, but they should be used with caution in patients at increased risk of adverse ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0601/p1933.html

Antidepressants in Older Persons - Cochrane for Clinicians - American Family Physician

Nov 1, 2006 - In older persons with depression, three classes of antidepressants are equally effective: selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and tricyclic-like compounds. More patients taking classic tricyclic antidepressants stopped their medications because of...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/1101/p1503.html

Antidepressants Plus Benzodiazepines for Adults with Major Depression - Cochrane for ... Restricted content. Login required.

May 1, 2020 - A combination of tricyclic antidepressants and benzodiazepines is more effective for major depression in adults than tricyclic antidepressants alone in the first four weeks of treatment.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0501/p527.html

Antidepressants to Treat Nonspecific Low Back Pain - Cochrane for Clinicians - American...

Jul 1, 2008 - Although antidepressants have been shown to be superior to placebo in some forms of chronic pain, they do not reduce pain or improve functional status or depression in patients with nonspecific low back pain.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0701/p51.html

Antiemetics for Acute Gastroenteritis–Related Vomiting in Children and Adolescents - ...

Jun 1, 2012 - Ondansetron (Zofran) given orally can reduce rates of vomiting, improve short-term tolerance of oral fluids, and reduce short-term rates of hospital admission and the need for intravenous hydration. Metoclopramide (Reglan) and ondansetron can reduce episodes of vomiting when given ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0601/p1054.html

Antiepileptic Drug Monotherapy for Epilepsy - Cochrane for Clinicians - American Family...

May 1, 2018 - In patients with partial-onset (focal) seizures, levetiracetam (Keppra), lamotrigine (Lamictal), and carbamazepine (Tegretol) were associated with the longest time to treatment withdrawal (i.e., the recommended patient-oriented outcome measure that balances tolerability with ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2018/0501/p572.html

Antihistamines for the Common Cold - Cochrane for Clinicians - American Family Physician

Aug 1, 2004 - Antihistamines are of minimal to no benefit as mono-therapy for the common cold, and first-generation antihistamines may increase sedation in patients with a cold. Antihistamine-decongestant combinations reduce nasal symptoms and improve the recovery rate in older children and adults, ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/0801/p486.html

Antihypertensive Agents for Prevention of Diabetic Nephropathy - Cochrane for ...

Jul 1, 2006 - Angiotensin-converting enzyme (ACE) inhibitors are the only antihypertensive agents with proven effectiveness for the primary prevention of diabetic nephropathy (defined as an albumin excretion of less than 30 mg per day on three serial measurements) caused by type 1 or type 2 diabetes....

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0701/p77.html

Antihypertensive Drug Therapy for Mild to Moderate Hypertension During Pregnancy - ... Restricted content. Login required.

Oct 1, 2019 - Compared with placebo, antihypertensive drug therapy for mild to moderate hypertension (defined by the authors as a blood pressure of 140 to 169 mm Hg systolic or 90 to 109 mm Hg diastolic) caused by chronic hypertension, gestational hypertension, or preeclampsia during pregnancy does ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/1001/p403.html

Antioxidant Supplements Do Not Improve Mortality and May Cause Harm - Cochrane for ...

Nov 1, 2008 - In randomized controlled trials of primary and secondary prevention, vitamins A and E, and beta-carotene supplementation increased mortality. Vitamin C and selenium supplementation had no significant effect on mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/1101/p1079.html

Antioxidants and Minerals for Age-Related Macular Degeneration - Cochrane for ...

Sep 1, 2006 - Supplementation with a combination of vitamin C, vitamin E, beta-carotene, and zinc modestly reduces the progression of ARMD in patients with disease in one or both eyes. High-dose vitamin supplements should not be recommended for patients without ARMD because of the possible harmful ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0901/p750.html

Antiplatelet Therapy and Anticoagulation in Patients with Hypertension - Cochrane for ...

Mar 1, 2005 - Antiplatelet agents should not be used in patients with hypertension and no previous history of heart attack or stroke. However, these agents are recommended for use in hypertensive patients who already have vascular disease. Anticoagulants should not be used for prevention of vascular ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0301/p897.html

Antiplatelet vs. Anticoagulation Therapy for Patients with Heart Failure in Sinus ...

Aug 1, 2017 - Heart failure increases the risk of thrombotic complications, but use of warfarin does not lower all-cause mortality more than aspirin in patients with heart failure with reduced ejection fraction in sinus rhythm.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0801/p160.html

Antiretroviral Preexposure Prophylaxis for Preventing HIV Infection in High-Risk ...

Aug 1, 2013 - For some groups of patients at greater risk of HIV infection (e.g., serodiscordant partners, men who have sex with men and engage in high-risk behaviors, persons with multiple concurrent sex partners, persons who exchange sex for money), preexposure prophylaxis decreased the risk of ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0801/p172.html

Antiretroviral Prophylaxis for Occupational Exposure to HIV - Cochrane for Clinicians -...

Aug 1, 2007 - The literature shows that acarbose can reduce the risk of type 2 diabetes in patients with impaired glucose tolerance or impaired fasting glucose. However, it is unclear whether the drug stops or delays the development of the disease or masks the diagnosis. There is no evidence that ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0801/p375.html

Antiretroviral Therapy to Prevent Transmission in HIV-Discordant Couples - Cochrane for...

Mar 1, 2012 - Rates of HIV transmission are at least three times lower in HIV-discordant couples in which the partner with infection is receiving antiretroviral therapy, compared with HIV-discordant couples in which the partner with infection is not receiving therapy. Among HIV-discordant couples in ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0301/p445.html

Antiviral Therapy for Bell Palsy - Cochrane for Clinicians - American Family Physician

May 1, 2016 - The combination of antiviral agents and corticosteroids is more effective than corticosteroids alone for the complete recovery of patients with Bell palsy (number needed to treat [NNT] = 15) and for the resolution of motor synkinesis and excessive tear production (NNT = 12). Antivirals ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/0501/p742.html

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