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Effects of Inhaled Corticosteroids on Growth in Children with Persistent Asthma - ... Restricted content. Login required.

Oct 1, 2020 - Inhaled fluticasone (Flovent; 200 mcg per day) is associated with a greater linear growth velocity when compared with beclomethasone (400 mcg per day; an equivalent dose).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/1001/p404.html

Corticosteroids for Hospitalized Patients with Community-Acquired Pneumonia - Cochrane ... Restricted content. Login required.

Sep 1, 2020 - For adults hospitalized with severe CAP, the use of corticosteroids may reduce the likelihood of mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0901/p272.html

Effectiveness of PPAR Gamma Agonists in Preventing Recurrent Stroke and Other Vascular ... Restricted content. Login required.

Sep 1, 2020 - PPAR gamma agonists are probably effective in preventing recurrent stroke in people with previous stroke or TIA.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0901/p271.html

Heavy Menstrual Bleeding in Premenopausal Patients and the Role of NSAIDs - Cochrane ... Restricted content. Login required.

Aug 1, 2020 - NSAIDs are effective for reducing heavy menstrual bleeding in premenopausal patients with menorrhagia when compared with placebo.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0801/p147.html

Role of Mucolytics in the Treatment of Chronic Bronchitis or COPD - Cochrane for ... Restricted content. Login required.

Jul 1, 2020 - Oral mucolytic agents may reduce the number of acute exacerbations in patients with chronic bronchitis or COPD (number needed to treat [NNT] = 8 over an average of nine months; 95% CI, 7 to 10).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0701/p16.html

Nicotine Replacement Therapy for Smoking Cessation - Cochrane for Clinicians - American... Restricted content. Login required.

Jul 1, 2020 - Patients using a combination of nicotine patch and fast-acting NRT are more likely to quit smoking than those on any single therapy alone (number needed to treat [NNT] = 29; 95% CI, 20 to 47).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0701/p17.html

Smoking Cessation with Text Messaging and App-Based Interventions - Cochrane for ... Restricted content. Login required.

Aug 1, 2020 - Automated text messaging interventions are more effective than minimal smoking cessation support (absolute risk reduction [ARR] = 3%; 95% CI, 1% to 5%).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0801/p148.html

Antidepressants Plus Benzodiazepines for Adults with Major Depression - Cochrane for ... Restricted content. Login required.

May 1, 2020 - A combination of tricyclic antidepressants and benzodiazepines is more effective for major depression in adults than tricyclic antidepressants alone in the first four weeks of treatment.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0501/p527.html

Renin-Angiotensin System Inhibitors vs. Other Antihypertensive Drug Classes for ... Restricted content. Login required.

Nov 1, 2019 - RAS inhibitors, which include angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, and renin inhibitors, should not be used as first-line agents.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/1101/p540.html

Lithium for Acute Mania - Cochrane for Clinicians - American Family Physician Restricted content. Login required.

May 1, 2020 - Lithium is more effective at inducing a reduction of at least 50% on the validated Young Mania Rating Scale compared with placebo (number needed to treat [NNT] = 6; 95% CI, 5 to 8; six studies; n = 1,707).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0501/p528.html

Music Therapy for Depression - Cochrane for Clinicians - American Family Physician Restricted content. Login required.

Mar 1, 2020 - Moderate-quality evidence shows that music therapy added to standard care is more effective in the first three months than standard care alone for depressive symptoms based on clinician-rated outcomes and patient-reported outcomes.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0301/p273.html

OnabotulinumtoxinA for Prevention of Migraine in Adults - Cochrane for Clinicians - ... Restricted content. Login required.

Feb 1, 2020 - OnabotulinumtoxinA reduces the number of migraine days per month by two days compared with placebo in adults with chronic migraines.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0201/p144.html

Pelvic Floor Muscle Training vs. Control for Urinary Incontinence in Women - Cochrane ... Restricted content. Login required.

Apr 1, 2020 - Use of pelvic floor muscle training to treat women with all subtypes of urinary incontinence results in improvement or cure vs. no treatment (number needed to treat [NNT] = 2.5; 95% CI, 1.4 to 5.4). Treatment with pelvic floor muscle training also results in one fewer episode of leakage...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0401/p393.html

Positional Therapy for Obstructive Sleep Apnea - Cochrane for Clinicians - American ... Restricted content. Login required.

Jan 1, 2020 - Positional therapy for OSA reduces scores on the apnea-hypopnea index (AHI) and Epworth Sleepiness Scale compared with no treatment. Although continuous positive airway pressure (CPAP) improves AHI scores more than positional therapy, patients seem to better tolerate positional therapy ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2020/0101/p16.html

Treatment of Threatened Miscarriage with Progestogens - Cochrane for Clinicians - ...

Sep 1, 2019 - Progestogens reduce the risk of miscarriage when compared with placebo in patients with threatened miscarriage (number needed to treat [NNT] = 10.) Use of progestogens poses no significant risks to mother or baby.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0901/p279.html

Oral H1 Antihistamines as Add-on Therapy to Topical Treatment for Eczema - Cochrane for... Restricted content. Login required.

Nov 1, 2019 - In children with eczema, there is no evidence to support the addition of oral H1 antihistamines to standard treatment regimens. In adults, the use of fexofenadine (Allegra), 120 mg per day, improves patient-assessed eczema symptoms compared with placebo (number needed to treat = 11; 95%...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/1101/p541.html

Combined Hormonal Contraceptives for Heavy Menstrual Bleeding - Cochrane for Clinicians... Restricted content. Login required.

Dec 1, 2019 - Combined oral contraceptives decrease the number of women reporting menorrhagia over six months compared with placebo (absolute risk reduction = 36.7%; number needed to treat = 2.7).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/1201/p677.html

Use of Amphetamines for Attention Deficit/Hyperactivity Disorder in Adults - Cochrane ...

Sep 1, 2019 - Amphetamines provide a clinician-rated 30% or greater reduction in ADHD symptoms when compared with placebo (number needed to treat = 5).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0901/p278.html

Antihypertensive Drug Therapy for Mild to Moderate Hypertension During Pregnancy - ...

Oct 1, 2019 - Compared with placebo, antihypertensive drug therapy for mild to moderate hypertension (defined by the authors as a blood pressure of 140 to 169 mm Hg systolic or 90 to 109 mm Hg diastolic) caused by chronic hypertension, gestational hypertension, or preeclampsia during pregnancy does ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/1001/p403.html

Medication Management for Chronic Heart Failure with Preserved Ejection Fraction - ...

Jul 1, 2019 - Mineralocorticoid receptor antagonists reduce hospitalizations for patients with HFpEF. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have not been shown to change the morbidity or mortality in patients with HFpEF.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0701/p17.html

Effectiveness and Safety of Factor Xa Inhibitors in Patients with Atrial Fibrillation -...

Oct 1, 2019 - Treatment of AFib with a factor Xa inhibitor results in a decrease in the combined end point of stroke and embolic events (odds ratio [OR] = 0.89; 95% CI, 0.82 to 0.97), as well as a decrease in intracranial hemorrhage (OR = 0.50; 95% CI, 0.42 to 0.59) and all-cause mortality (OR = ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/1001/p405.html

Aromatase Inhibitors Such as Letrozole (Femara) vs. Clomiphene (Clomid) for Subfertile ...

May 1, 2019 - When treated with letrozole, subfertile women with PCOS who are trying to conceive have increased chances of pregnancy (number needed to treat [NNT] = 11) and live birth (NNT = 10) compared with those treated with clomiphene.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0501/p545.html

Anticoagulation for the Long-term Treatment of VTE in Patients with Cancer - Cochrane ...

Jun 1, 2019 - Low-molecular-weight heparin (LMWH), vitamin K antagonists, and direct oral anticoagulants, when used to prevent recurrent VTE, have a similar impact on all-cause mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0601/p676.html

Different Durations of Corticosteroid Therapy for COPD Exacerbations - Cochrane for ...

Mar 1, 2019 - Treatment of acute exacerbations of COPD with a shorter course of systemic corticosteroids (seven or fewer days) is likely to be as effective and safe as treating with longer courses (more than seven days).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0301/p295.html

Alternative Interventions for Chronic Prostatitis/Chronic Pelvic Pain Syndrome in Men -...

Jun 1, 2019 - In men with chronic pelvic pain and urinary dysfunction who have not responded to standard medical management, extracorporeal shock wave therapy reduces symptoms and increases quality of life. Acupuncture may also provide benefit to some patients.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0601/p677.html

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