Diagnosis of Acute Abdominal Pain in Older Patients

Am Fam Physician. 2006 Nov 1;74(9):1537-1544.

Acute abdominal pain is a common presenting complaint in older patients. Presentation may differ from that of the younger patient and is often complicated by coexistent disease, delays in presentation, and physical and social barriers. The physical examination can be misleadingly benign, even with catastrophic conditions such as abdominal aortic aneurysm rupture and mesenteric ischemia. Changes that occur in the biliary system because of aging make older patients vulnerable to acute cholecystitis, the most common indication for surgery in this population. In older patients with appendicitis, the initial diagnosis is correct only one half of the time, and there are increased rates of perforation and mortality when compared with younger patients. Medication use, gallstones, and alcohol use increase the risk of pancreatitis, and advanced age is an indicator of poor prognosis for this disease. Diverticulitis is a common cause of abdominal pain in the older patient; in appropriately selected patients, it may be treated on an outpatient basis with oral antibiotics. Small and large bowel obstructions, usually caused by adhesive disease or malignancy, are more common in the aged and often require surgery. Morbidity and mortality among older patients presenting with acute abdominal pain are high, and these patients often require hospitalization with prompt surgical consultation.

Acute abdominal pain (generally defined as pain of less than one week’s duration) is a common presenting complaint among older patients. Approximately one fourth of patients who present to the emergency department are older than 50 years.1 The presentation of an older patient with abdominal pain may be very different from that seen in a younger patient.27 Older patients tend to present later in the course of their illness and have more nonspecific symptoms. In addition, a broader differential diagnosis must be considered in older patients with abdominal pain. Older patients may delay seeking care because they fear losing independence, lack health insurance, lack transportation, lack a secondary caregiver for their spouse or pet, or are afraid of hospitals or death.8  Table 1810 lists medical assessment challenges that can make an accurate diagnosis more difficult once older patients do seek care for abdominal pain.

SORT: KEY RECOMMENDATIONS FOR PRACTICE

Clinical recommendation Evidence rating References

Consider cholecystitis even if an older patient does not present with classic symptoms, because they often are absent in older persons.

C

19,20

Consider small bowel obstruction in the older patient with a history of surgery who presents with diffuse, colicky pain, nausea, vomiting, altered bowel sounds, distention, dehydration, diffuse tenderness, and possibly an ill-defined mass.

C

4,5

Consider abdominal aortic aneurysm in the older patient with back or abdominal pain, particularly if they are male or have a history of tobacco use.

C

42

Consider acute mesenteric ischemia if a patient presents with severe, poorly localized pain out of proportion to physical findings.

C

44,45


A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, see page 1463 or http://www.aafp.org/afpsort.xml.

SORT: KEY RECOMMENDATIONS FOR PRACTICE

View Table

SORT: KEY RECOMMENDATIONS FOR PRACTICE

Clinical recommendation Evidence rating References

Consider cholecystitis even if an older patient does not present with classic symptoms, because they often are absent in older persons.

C

19,20

Consider small bowel obstruction in the older patient with a history of surgery who presents with diffuse, colicky pain, nausea, vomiting, altered bowel sounds, distention, dehydration, diffuse tenderness, and possibly an ill-defined mass.

C

4,5

Consider abdominal aortic aneurysm in the older patient with back or abdominal pain, particularly if they are male or have a history of tobacco use.

C

42

Consider acute mesenteric ischemia if a patient presents with severe, poorly localized pain out of proportion to physical findings.

C

44,45


A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, see page 1463 or http://www.aafp.org/afpsort.xml.

TABLE 1

Potential Challenges to the Clinical Assessment of Abdominal Pain in Older Patients

History taking

Altered mentation from fever or electrolyte abnormalities; cognitive impairment; decreased mentation from drugs (e.g., opiates, benzodiazepines); dementia; hearing difficulties; intoxication; language barriers; psychiatric disorders

Clinical assessment

Absence of fever despite a serious bacterial infection or surgical condition9; absence of leukocytosis despite a surgical condition; altered pain perception from chronic pain medications; coexistent disease; four times higher likelihood of hypothermic response with a significant intra-abdominal process10; lower likelihood of localized tenderness despite a focal surgical condition; reduced rebound and guarding from decreased abdominal wall musculature; suppressed tachycardia from medications or intrinsic cardiac disease


Information from references 8 through 10.

TABLE 1   Potential Challenges to the Clinical Assessment of Abdominal Pain in Older Patients

View Table

TABLE 1

Potential Challenges to the Clinical Assessment of Abdominal Pain in Older Patients

History taking

Altered mentation from fever or electrolyte abnormalities; cognitive impairment; decreased mentation from drugs (e.g., opiates, benzodiazepines); dementia; hearing difficulties; intoxication; language barriers; psychiatric disorders

Clinical assessment

Absence of fever despite a serious bacterial infection or surgical condition9; absence of leukocytosis despite a surgical condition; altered pain perception from chronic pain medications; coexistent disease; four times higher likelihood of hypothermic response with a significant intra-abdominal process10; lower likelihood of localized tenderness despite a focal surgical condition; reduced rebound and guarding from decreased abdominal wall musculature; suppressed tachycardia from medications or intrinsic cardiac disease


Information from references 8 through 10.

Outcomes in Older Patients

Morbidity and mortality among older patients with abdominal pain are high; evaluation and management often requires admission to the hospital and surgical consultation.2,11 In retrospective studies, more than one half of older patients presenting to the emergency department with acute abdominal pain required hospital admission, and 20 to 33 percent required immediate surgery.2,1113 Surgical intervention occurs twice as often in older patients when compared with a younger population.13 Overall mortality rates from retrospective series vary from 2 to 13 percent.6,11,12 The mortality rate for emergency abdominal surgery is 15 to 34 percent, with the primary cause being an underlying or coexisting disease.5,12,1416

In a retrospective study of 380 older patients with acute abdominal pain, the presence of free air on plain film radiographs, leukocytosis with a high neutrophilic band count, and age older than 84 years were associated with an increased risk of death.11 In the same study, variables associated with the need for surgical intervention included hypotension, abnormal bowel sounds, radiographic abnormalities (e.g., dilated bowel loops, free air, air-fluid levels), and leukocytosis.11

Differential Diagnosis

The causes of acute abdominal pain in older patients are not greatly dissimilar from the causes in younger patients; however, certain disease processes occur more often in older patients.

CHOLECYSTITIS

Biliary tract disease, including cholecystitis, is the most common indication for surgery in older patients with abdominal pain, accounting for one third of patients older than 55 years presenting to the emergency department with acute abdominal pain.1,2,17 Age-related changes in the biliary tract, such as an increased prevalence of gallstones, increased lithogenicity of the bile, a greater percentage of pigmented stones, and an increase of the common bile duct diameter, are thought to account for the increased incidence of gallstone disease.18

The patient with acute cholecystitis usually presents with unremitting and intensifying pain at the right side of the abdomen, often associated with fever and vomiting. Indicators such as right upper quadrant pain and Murphy’s sign (i.e., inspiratory arrest with palpation of the right upper quadrant) are present in about one half of older patients with cholecystitis and are less accurate than in younger patients.19 In fact, a significant number of older patients do not have classic symptoms of cholecystitis. A retrospective case series of 168 patients older than 65 years with acute cholecystitis concluded that over 60 percent of patients did not have back or flank pain and 5 percent had no pain at all.20 Over 40 percent of patients did not experience nausea, more than one half were afebrile, and 41 percent had a normal white blood cell count.20 Thirteen percent of patients with acute cholecystitis had no abnormal liver function tests, fever, or leukocytosis.20

Complications of acute cholecystitis occur in more than one half of all patients older than 65 years.19 Such complications include acute ascending cholangitis, gallbladder perforation, emphysematous cholecystis, bile peritonitis, and gallstone ileus. Acute ascending cholangitis rarely occurs before age 40 years. Most patients with acute ascending cholangitis present with Charcot’s triad (i.e., fever, jaundice, and right upper quadrant pain). The majority of patients have an elevated alkaline phosphatase level, 50 percent have positive blood cultures, and approximately 40 percent have hyperbilirubinemia.19 Reynold’s pentad (i.e., Charcot’s triad plus shock and mental status changes) is reported to occur in only 14 percent of cases.21

APPENDICITIS

Older patients with appendicitis are more likely to present with generalized pain, longer duration of pain, distention, rigidity, decreased bowel sounds, and a mass. A recent multicenter prospective abdominal pain intervention study attributes the differences in presentation of older patients to the delay in presentation, not to a difference in the disease process.22

A retrospective review of 65 patients older than 60 years with pathology-confirmed appendicitis concluded that fever alone was a poor predictor of acute appendicitis in older patients; only 23 percent of patients with appendicitis had a temperature greater than 100° F (37.7° C).23 In the same study, a band count greater than 6 percent and right lower quadrant pain were highly associated with confirmed appendicitis (positive predictive values of 100 and 90 percent, respectively). However, this study was poorly designed and probably overstated the accuracy of the latter findings.23

Diagnosis may be aided by contrast-enhanced spiral computed tomography (CT)24,25; however, one study comparing outcomes before and after widespread use of CT found that increasing use of CT and diagnostic laparoscopy had no impact on mortality or length of stay in the older population.26

ACUTE PANCREATITIS

Advanced age is an indicator of poor prognosis for persons with acute pancreatitis. Mortality rates in older patients with pancreatitis are reported to be 20 to 25 percent, compared with 8 to 10 percent in the general population.18 Factors that cause acute pancreatitis in older patients include alcoholism, biliary tract disease, infections, hypertriglyceridemia, a variety of medications, hypercalcemia, hypothermia, and carbon monoxide exposure.4,18 Gallstone pancreatitis accounts for most cases (65 to 75 percent) of acute pancreatitis in older patients.18

As with younger patients, older patients typically present with nausea, vomiting, dehydration, and midepigastric pain that is constant in nature.4 The pain may radiate to the back, and the intensity may vary in older patients. Serum amylase levels of five times the upper limit of normal, used as a diagnostic indicator, have a specificity of 70 to 100 percent and a sensitivity of 79 to 95 percent.27 Lipase level is equally as sensitive and slightly more specific (80 to 100 percent), because mild elevations in amylase can be associated with other processes such as mesenteric ischemia or peptic ulcer and bowel perforation.14,27

PEPTIC ULCER DISEASE AND PERFORATION

Peptic ulcer disease accounts for 16 percent of older patients complaining of abdominal pain.28 Nonsteroidal anti-inflammatory drugs (NSAIDs) and infection withHelicobacter pylori are the most important risk factors for peptic ulcer disease; the odds ratio for NSAID use and peptic ulcer is 2.7 forH. pylori–positive patients and 5.3 forH. pylori–negative patients.29

Symptoms of peptic ulcer disease are usually absent or vague and poorly localized; approximately 30 percent of patients older than 60 years with confirmed peptic ulcer disease have no abdominal pain.30 Often, the first sign of the disease is with an acute complication, such as perforation. Abdominal pain with a perforation classically occurs with an abrupt onset, is located in the epigastrium, presents with absent bowel sounds, and is associated with abdominal rigidity. Up to one third of patients with peptic ulcer disease do not have any pain, particularly among those taking NSAIDs.5,19,30 Elevated serum amylase and leukocytosis can develop quickly with perforation caused by pancreatic amylase spilling into the peritoneal cavity.28 Plain film abdominal radiographs are helpful if free air is seen; however, up to 50 percent of cases of perforated ulcers do not show free air.5 Barium contrast studies and upper endoscopy can confirm the diagnosis of peptic ulcer disease; however, they are contraindicated if perforation is suspected.31 Ultrasonography or CT can be useful to detect intraperitoneal free fluid or air if the diagnosis is uncertain.32

DIVERTICULAR DISEASE

The incidence of diverticular disease increases with age and is estimated to affect two thirds of those older than 90 years (in contrast to 5 percent of the general population).4,33 Over 90 percent of diverticular disease involves the sigmoid colon.33 Ten to 30 percent of patients with diverticulosis will develop painful diverticular disease or diverticulitis.2,33

Painful diverticular disease is characterized by attacks of localized abdominal pain in the absence of inflammation (i.e., no evidence of fever, leukocytosis, or peritoneal signs on examination). Diverticulitis probably occurs when there is microperforation of one or more diverticula. Because the sigmoid colon most commonly is affected, patients typically present with left lower quadrant pain and signs of inflammation. The pain of diverticulitis is more acute and more severe than that of painful diverticular disease. The diagnosis often is made clinically. CT is the modality of choice when the diagnosis is uncertain or an abscess or fistula is suspected.34 Barium enema and colonoscopy should be avoided in the acute phase because of the risk of expanding a localized perforation.4,5,33

SMALL BOWEL OBSTRUCTION

Small bowel obstruction in older patients most commonly is caused by adhesions from previous surgery (50 to 70 percent) and hernias (15 to 30 percent).4,5,7,14,19,35 Patients typically experience diffuse, colicky pain, nausea, and vomiting. On physical examination there may be altered bowel sounds, distention, dehydration, diffuse tenderness, and possibly an ill-defined mass. Peritoneal signs will be present if perforation has occurred.

Small bowel obstruction most commonly is diagnosed with plain film radiographs that show distended small bowel loops (greater than 2.5 to 3.0 cm), air-fluid levels, and a paucity of large bowel air (Figure 1). However, radiographic findings are normal in 25 to 40 percent of patients.36

Figure 1.

Plain film radiograph of dilated loops of small bowel in small bowel obstruction.

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Figure 1.

Plain film radiograph of dilated loops of small bowel in small bowel obstruction.


Figure 1.

Plain film radiograph of dilated loops of small bowel in small bowel obstruction.

Gallstone ileus is a rare but important cause of small bowel obstruction in older patients.5,14,35 It has been implicated as the cause of small bowel obstruction in up to 20 percent of patients older than 65 years.5,14 In gallstone ileus, a gallstone (usually larger than 2.5 cm) lodges in the distal ileum. Patients present with the classic triad of small bowel obstruction, air in the biliary tree, and calculus on plain film radiographs. One half of patients have a history of gallbladder disease, and it is more common in women. Diagnosis often is delayed, and mortality rates of 15 percent or higher have been reported.4,19

LARGE BOWEL OBSTRUCTION

Malignancy is the most common cause of large bowel obstruction in older patients. Colon carcinoma without obstruction does not usually cause acute abdominal pain. Diverticulitis and colonic volvulus (i.e., narrowed, twisted lumen with a bird’s beak appearance) are less common causes of large bowel obstruction.4,5,14,35

Sigmoid volvulus is the most common type of colonic volvulus (75 to 80 percent of cases).37 Laxative use, sedatives, anticholinergics, and antiparkinson medicines predispose patients to a volvulus. Chronic distention, elongation, and increased mobility of the colon allow parts of the colon to twist on itself.

Symptoms of large bowel obstruction tend to be insidious in onset, and presentation is similar to small bowel obstruction.5,35 Feculent emesis, guaiac-positive stools, weight loss, and anemia may be present. Plain film radiographs will demonstrate a dilated large bowel (greater than 5 cm) with haustral markings that incompletely traverse the circumference of the bowel. Risk of perforation occurs with dilation of more than 9 cm.19 Barium enema can confirm the diagnosis, especially in cases of volvulus.19

ABDOMINAL AORTIC ANEURYSM

Abdominal aortic aneurysms (AAAs) usually are infrarenal in origin and commonly extend into the iliac arteries.Most are diagnosed on routine examination or as an incidental finding on an imaging study. Patients at highest risk for AAA are older men who use tobacco and have hypertension, peripheral vascular disease, and a family history of AAA.4,14,3840 Smoking is the strongest independent risk factor; 90 percent of patients with AAA have used tobacco.3840 The U.S. Preventive Services Task Force recently recommended screening for AAA in all males between 65 and 75 years of age with a history of smoking tobacco.41

Significant AAA may be asymptomatic. When symptoms develop, they are usually nonspecific, such as abdominal pain, backache, or claudication. Signs and symptoms of AAA rupture most commonly include severe abdominal pain, back or flank pain, hypotension, and a pulsatile mass on examination.3 The classic triad for a ruptured AAA (i.e., hypotension, back pain, and a pulsatile mass) is present in only 25 to 50 percent of cases.42,43 A palpable mass with flank ecchymosis is highly suggestive of a ruptured AAA. Abdominal pain and backache are common presenting symptoms.42,43 Presentation may resemble acute cholecystitis, perforated ulcer, diverticulitis, or renal colic.3,43 For this reason, patients with AAA often are misdiagnosed.43

Plain radiographs may show calcifications of the aneurysm, a soft tissue mass, loss of the psoas shadow, or loss of renal outline. Ultrasonography is a fast, safe, and reliable way to distinguish an abdominal aneurysm from another intra-abdominal process and may be performed at the bedside. Urgent CT should be reserved for clinically stable patients and to identify whether a leaking or dissecting aortic aneurysm is present.5 See Figure 2 for an example of a dissecting aneurysm.

Figure 2.

Computed tomography scan demonstrating a dissecting abdominal aortic aneurysm with an intimal flap(arrow) evident at the level of the kidneys.

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Figure 2.

Computed tomography scan demonstrating a dissecting abdominal aortic aneurysm with an intimal flap(arrow) evident at the level of the kidneys.


Figure 2.

Computed tomography scan demonstrating a dissecting abdominal aortic aneurysm with an intimal flap(arrow) evident at the level of the kidneys.

ACUTE MESENTERIC ISCHEMIA

Acute mesenteric ischemia is an uncommon but often fatal cause of acute abdominal pain in older patients. It has been reported to account for 0.1 percent of all hospital admissions and 1 percent of admissions for acute abdominal pain.44

Approximately one half of patients older than 45 years have some degree of atherosclerosis of the celiac, superior, and inferior mesenteric arteries.4 Particularly in smokers, this increases the risk of acute mesenteric ischemia.44  The superior mesenteric artery most commonly is implicated in acute mesenteric ischemia. The four major causes of acute mesenteric ischemia are arterial embolism, arterial thrombosis, nonocclusive ischemia, and mesenteric venous thrombosis. Key features of the four major causes of acute mesenteric ischemia are shown in Table 2.44,45

TABLE 2

Causes of Acute Mesenteric Ischemia and Associated Features

Etiology Distribution (%) Comments

Superior mesenteric artery embolism

50

Embolus is usually cardiac in origin from a dislodged thrombus (i.e., left atrium, left ventricle, or valvular lesion).

Risk factors include atrial fibrillation, cardiac chamber dilation, acute myocardial infarction, and left-sided valvular vegetations.

Triad includes acute abdominal pain, history of cardiac disease, and acute gastrointestinal emptying (i.e., diarrhea or vomiting).

Superior mesenteric artery thrombosis

15 to 25

Usually superimposed on chronic mesenteric ischemia from progressive atherosclerotic disease

Not usually associated with coagulation defects

May have a history of chronic postprandial abdominal pain, weight loss, and other gastrointestinal symptoms.

Bloody stools, hematemesis, and metabolic and electrolyte abnormalities are late presenting signs.

Nonocclusive ischemia

20

Catchall category typically caused by low-flow states (e.g., cardiogenic shock, sepsis, dialysis, hypovolemia); obstruction (e.g., intussusception, strangulated hernia); trauma; or medications (e.g., vasoconstrictors).

Mesenteric venous thrombosis

5

Portal hypertension, intra-abdominal trauma or sepsis, intra-abdominal malignancy, and hypercoagulable states are risk factors.

Suspected in patients with acute abdominal pain and history of thrombotic episodes and coagulopathy

Prompt anticoagulation may preserve bowel viability.


Information from references 44 and 45.

TABLE 2   Causes of Acute Mesenteric Ischemia and Associated Features

View Table

TABLE 2

Causes of Acute Mesenteric Ischemia and Associated Features

Etiology Distribution (%) Comments

Superior mesenteric artery embolism

50

Embolus is usually cardiac in origin from a dislodged thrombus (i.e., left atrium, left ventricle, or valvular lesion).

Risk factors include atrial fibrillation, cardiac chamber dilation, acute myocardial infarction, and left-sided valvular vegetations.

Triad includes acute abdominal pain, history of cardiac disease, and acute gastrointestinal emptying (i.e., diarrhea or vomiting).

Superior mesenteric artery thrombosis

15 to 25

Usually superimposed on chronic mesenteric ischemia from progressive atherosclerotic disease

Not usually associated with coagulation defects

May have a history of chronic postprandial abdominal pain, weight loss, and other gastrointestinal symptoms.

Bloody stools, hematemesis, and metabolic and electrolyte abnormalities are late presenting signs.

Nonocclusive ischemia

20

Catchall category typically caused by low-flow states (e.g., cardiogenic shock, sepsis, dialysis, hypovolemia); obstruction (e.g., intussusception, strangulated hernia); trauma; or medications (e.g., vasoconstrictors).

Mesenteric venous thrombosis

5

Portal hypertension, intra-abdominal trauma or sepsis, intra-abdominal malignancy, and hypercoagulable states are risk factors.

Suspected in patients with acute abdominal pain and history of thrombotic episodes and coagulopathy

Prompt anticoagulation may preserve bowel viability.


Information from references 44 and 45.

Classically, the patient with acute mesenteric ischemia presents with severe, poorly localized abdominal pain that is out of proportion to physical findings. One third of patients will have nausea, vomiting, or diarrhea, often mimicking gastroenteritis. Distention, shock, and peritoneal irritation are late findings signaling infarction and perforation.44,45 Only 25 percent of patients will have positive fecal occult blood tests.14 Leukocytosis often is present. Metabolic acidosis and elevated serum lactate and amylase may be present if infarction has occurred, but these can be normal in early ischemia.14,44,45

Plain film radiographs may initially be unremarkable; an adynamic ileus, distention, air-fluid levels, and fixed dilated loops may be seen as the ischemia goes untreated. A CT scan may reveal bowel wall thickening from edema or hemorrhage and intestinal wall gas. CT may rule out other pathology and may detect superior mesenteric vein thrombosis.44,45 Angiography is recommended to confirm the diagnosis if mesenteric ischemia is strongly suspected.44,45

ATYPICAL CAUSES

Other problems may present as acute abdominal pain in older patients, including urinary tract infection, pyelonephritis, myocardial infarction (inferior wall), pulmonary embolism, congestive heart failure with hepatic congestion, pneumonia, constipation, urinary retention, or an abdominal muscle injury.

Approach to the Patient

Table 3 summarizes pertinent laboratory evaluations, imaging studies, and associated diagnoses. An algorithm for evaluation of the acutely ill older patient with abdominal pain is shown in Figure 3. A careful history and physical examination will help determine the urgency of the remaining evaluation and direct it toward specific laboratory and imaging studies (Table 3). Most patients should have chest and abdominal radiographs, looking in particular for signs of pneumonia, mesenteric ischemia, bowel obstruction, and free air. If the diagnosis is not made at this point, urgent evaluation with ultrasonography or CT (or angiography if mesenteric ischemia is suspected) should be considered. If peptic ulcer disease is suspected, a gastroenterologist should be consulted to consider upper endoscopy with biopsy.

TABLE 3

Laboratory and Imaging Studies for Diagnosing Patients with Acute Abdominal Pain

Study Etiology

Abdominal CT

Appendicitis; diverticulitis; bowel obstruction; pancreatitis (necrosis); abdominal aortic aneurysm in stable patient; mesenteric ischemia

Abdominal radiography

Bowel perforation (free air); bowel obstruction/volvulus (dilated bowel and air-fluid levels); abdominal aortic aneurysm (dilated calcified aorta); mesenteric ischemia (dilated loops, air-fluid levels, pneumatosis intestinalis [gas in bowel wall], thumbprinting [edema of bowel wall with convex indentations of lumen])

Amylase

Pancreatitis (less specific than lipase); bowel obstruction; peptic ulcer perforation; bowel perforation; mesenteric ischemia

Angiography

Mesenteric ischemia

Blood cultures

Infection

Chest radiography

Pneumonia; free air under diaphragm

Electrocardiography

Nonabdominal emergencies such as myocardial infarction or pulmonary embolism

Electrolytes

Diabetic ketoacidosis; electrolyte abnormalities; metabolic acidosis with bowel infarction (mesenteric ischemia)

Leukocytosis

Infection; intestinal ischemia; perforated peptic ulcer

Lipase

Pancreatitis; bowel obstruction; duodenal ulcer

Liver function test and transaminases

Cholecystitis (most commonly elevated alkaline phosphatase, H-glutamyltransferase, elevated bilirubin); mesenteric ischemia (possible elevated alkaline phosphatase)

Pulse oximetry

Pneumonia; pulmonary embolism

Ultrasonography

Cholecystitis; appendicitis (less accurate than CT, more operator dependent); abdominal aortic aneurysm in unstable patient

Urinalysis

Urinary tract infection


CT = computed tomography

TABLE 3   Laboratory and Imaging Studies for Diagnosing Patients with Acute Abdominal Pain

View Table

TABLE 3

Laboratory and Imaging Studies for Diagnosing Patients with Acute Abdominal Pain

Study Etiology

Abdominal CT

Appendicitis; diverticulitis; bowel obstruction; pancreatitis (necrosis); abdominal aortic aneurysm in stable patient; mesenteric ischemia

Abdominal radiography

Bowel perforation (free air); bowel obstruction/volvulus (dilated bowel and air-fluid levels); abdominal aortic aneurysm (dilated calcified aorta); mesenteric ischemia (dilated loops, air-fluid levels, pneumatosis intestinalis [gas in bowel wall], thumbprinting [edema of bowel wall with convex indentations of lumen])

Amylase

Pancreatitis (less specific than lipase); bowel obstruction; peptic ulcer perforation; bowel perforation; mesenteric ischemia

Angiography

Mesenteric ischemia

Blood cultures

Infection

Chest radiography

Pneumonia; free air under diaphragm

Electrocardiography

Nonabdominal emergencies such as myocardial infarction or pulmonary embolism

Electrolytes

Diabetic ketoacidosis; electrolyte abnormalities; metabolic acidosis with bowel infarction (mesenteric ischemia)

Leukocytosis

Infection; intestinal ischemia; perforated peptic ulcer

Lipase

Pancreatitis; bowel obstruction; duodenal ulcer

Liver function test and transaminases

Cholecystitis (most commonly elevated alkaline phosphatase, H-glutamyltransferase, elevated bilirubin); mesenteric ischemia (possible elevated alkaline phosphatase)

Pulse oximetry

Pneumonia; pulmonary embolism

Ultrasonography

Cholecystitis; appendicitis (less accurate than CT, more operator dependent); abdominal aortic aneurysm in unstable patient

Urinalysis

Urinary tract infection


CT = computed tomography

Approach to the Older Patient with Abdominal Pain

Figure 3.

Algorithm for evaluating the older patient with acute abdominal pain. (CAD = coronary artery disease; ECG = electrocardiography; UTI = urinary tract infection; MI = myocardial infarction; CHF = congestive heart failure; PE = pulmonary embolism; SBO = small bowel obstruction; LBO = large bowel obstruction; RUQ = right upper quadrant; AAA = abdominal aortic aneurysm; RLQ = right lower quadrant; CT = computed tomography.)

View Large

Approach to the Older Patient with Abdominal Pain


Figure 3.

Algorithm for evaluating the older patient with acute abdominal pain. (CAD = coronary artery disease; ECG = electrocardiography; UTI = urinary tract infection; MI = myocardial infarction; CHF = congestive heart failure; PE = pulmonary embolism; SBO = small bowel obstruction; LBO = large bowel obstruction; RUQ = right upper quadrant; AAA = abdominal aortic aneurysm; RLQ = right lower quadrant; CT = computed tomography.)

Approach to the Older Patient with Abdominal Pain


Figure 3.

Algorithm for evaluating the older patient with acute abdominal pain. (CAD = coronary artery disease; ECG = electrocardiography; UTI = urinary tract infection; MI = myocardial infarction; CHF = congestive heart failure; PE = pulmonary embolism; SBO = small bowel obstruction; LBO = large bowel obstruction; RUQ = right upper quadrant; AAA = abdominal aortic aneurysm; RLQ = right lower quadrant; CT = computed tomography.)

The Authors

COREY LYON, LCDR, MC, USN is a staff family physician at U.S. Naval Hospital Sigonella in Italy. He received his medical degree at the University of the Health Sciences - College of Osteopathic Medicine, Kansas City, Mo., and completed a family medicine residency at Naval Hospital Jacksonville (Fla.).

DWAYNE C. CLARK, M.D., is a family physician with the Fond du Lac Regional Clinic and Agnesian Healthcare in Fond du Lac, Wis. At the time Dr. Clark wrote this article, he was teaching in the Department of Family Medicine at Naval Hospital Jacksonville. He received his medical degree from Duke University School of Medicine, Durham, N.C., and completed a residency in family medicine at Naval Hospital Jacksonville.

Address correspondence to Corey Lyon, LCDR, MC, USN, Department of Family Medicine, Naval Hospital Sigonella, PSC 836, Box 2670, FPO, AE 09636 (e-mail: clyon@sig.med.navy.mil). Reprints are not available from the authors.

The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army Medical Department or the U.S. Navy at large.

Author disclosure: Nothing to disclose.

REFERENCES

1. de Dombal FT. Acute abdominal pain in the elderly. J Clin Gastroenterol. 1994;19:331–5.

2. Bugliosi TF, Meloy TD, Vukov LF. Acute abdominal pain in the elderly. Ann Emerg Med. 1990;19:1383–6.

3. Dang C, Aguilera P, Dang A, Salem L. Acute abdominal pain. Four classifications can guide assessment and management. Geriatrics. 2002;57:30–2,35–6,41–2.

4. Sanson TG, O’Keefe KP. Evaluation of abdominal pain in the elderly. Emerg Med Clin North Am. 1996;14:615–27.

5. Kauvar DR. The geriatric acute abdomen. Clin Geriatr Med. 1993;9:547–58.

6. Abi-Hanna P, Gleckman R. Acute abdominal pain: a medical emergency in older patients. Geriatrics. 1997;52:72–4.

7. Vogt DP. The acute abdomen in the geriatric patient. Cleve Clin J Med. 1990;57:125–30.

8. Rothrock SG, Greenfield RH, Falk JL. Acute abdominal emergencies in the elderly: clues to identifying serious illness. Part I – Clinical assessment and diagnostic studies. Emerg Med Reports. 1992;13:177–84.

9. Potts FE 4th, Vukov LF. Utility of fever and leukocytosis in acute surgical abdomens in octogenarians and beyond. J Gerontol A Biol Sci Med Sci. 1999;54:M55–8.

10. Cooper GS, Shlaes DM, Salata RA. Intraabdominal infection: differences in presentation and outcome between younger patients and the elderly. Clin Infect Dis. 1994;19:146–8.

11. Marco CA, Schoenfeld CN, Keyl PM, Menkes ED, Doehring MC. Abdominal pain in geriatric emergency patients: variables associated with adverse outcomes. Acad Emerg Med. 1998;5:1163–8.

12. Kizer KW, Vassar MJ. Emergency department diagnosis of abdominal disorders in the elderly. Am J Emerg Med. 1998;16:357–62.

13. Brewer BJ, Golden GT, Hitch DC, Rudolf LE, Wangensteen SL. Abdominal pain. An analysis of 1,000 consecutive cases in a University Hospital emergency room. Am J Surg. 1976;131:219–23.

14. Hendrickson M, Naparst TR. Abdominal surgical emergencies in the elderly. Emerg Med Clinic North Am. 2003;21:937–69.

15. Van Geloven AA, Biesheuvel TH, Luitse JS, Hoitsma HF, Obertop H. Hospital admissions of patients aged over 80 with acute abdominal complaints. Eur J Surg. 2000;166:866–71.

16. Arenal JJ, Bengoechea-Beeby M. Mortality associated with emergency abdominal surgery in the elderly. Can J Surg. 2003;46:111–6.

17. Kettunen J, Paajanen H, Kostiainen S. Emergency abdominal surgery in the elderly. Hepatogastroenterology. 1995;42:106–8.

18. Ross SO, Forsmark CE. Pancreatic and biliary disorders in the elderly. Gastroenterol Clin North Am. 2001;30:531–45.

19. Rothrock SG, Greenfield R, Falk JL. Acute abdominal emergencies in the elderly: clinical evaluation and management. Part II – Diagnosis and management of common conditions. Emerg Med Reports. 1992;13:185–92.

20. Parker LJ, Vukov LF, Wollan PC. Emergency department evaluation of geriatric patients with acute cholecystitis. Acad Emerg Med. 1997;4:51–5.

21. Hanau LH, Steigbigel NH. Acute (ascending) cholangitis. Infect Dis Clin North Am. 2000;14:521–46.

22. Kraemer M, Franke C, Ohmann C, Yang Q, for the Acute Abdominal Pain Study Group. Acute appendicitis in late adulthood: incidence, presentation, and outcome. Results of a prospective multicenter acute abdominal pain study and a review of the literature. Langenbecks Arch Surg. 2000;385:470–81.

23. Elangovan S. Clinical and laboratory findings in acute appendicitis in the elderly. J Am Board Fam Pract. 1996;9:75–8.

24. Rao PM, Rhea JT, Novelline RA, Mostafavi AA, McCabe CJ. Effect of computed tomography of the appendix on treatment of patients and use of hospital resources. N Engl J Med. 1998;338:141–6.

25. Stroman DL, Bayouth CV, Kuhn JA, Westmoreland M, Jones RC, Fisher TL, et al. . The role of computed tomography in the diagnosis of acute appendicitis. Am J Surg. 1999;178:485–9.

26. Hui TT, Major KM, Avital I, Hiatt JR, Margulies DR. Outcome of elderly patients with appendicitis: effect of computed tomography and laparoscopy. Arch Surg. 2002;137:995–8.

27. Vissers RJ, Abu-Laban RB, McHugh DF. Amylase and lipase in the emergency department evaluation of acute pancreatitis. J Emerg Med. 1999;17:1027–37.

28. McCarthy DM. Acid peptic disease in the elderly. Clin Geriatr Med. 1991;7:231–54.

29. Voutilainen M, Mantynen T, Farkkila M, Juhola M, Sipponen P. Impact of non-steroidal anti-inflammatory drug and aspirin use on the prevalence of dyspepsia and uncomplicated peptic ulcer disease. Scand J Gastroenterol. 2001;36:817–21.

30. Hilton D, Iman N, Burke GJ, Moore A, O’Mara G, Signorini D, et al. . Absence of abdominal pain in older persons with endoscopic ulcers: a prospective study. Am J Gastroenterol. 2001;96:380–4.

31. Saad RJ, Scheiman JM. Diagnosis and management of peptic ulcer disease. Clin Fam Pract. 2004;6:569–87.

32. Grassi R, Romano S, Pinto A, Romano L. Gastroduodenal perforations: conventional plain film, US and CT findings in 166 consecutive patients. Eur J Radiol. 2004;50:30–6.

33. Farrell RJ, Farrell JJ, Morrin MM. Diverticular disease in the elderly. Gastroenterol Clin North Am. 2001;30:475–96.

34. Balfe DM, Levine MS, Ralls PW, Bree RL, DiSantis DJ, Glick SN, et al. Evaluation of left lower quadrant pain. American College of Radiology. ACR Appropriateness Criteria. Radiology. 2000;215(suppl):167–71.

35. Soybel D. Ileus and bowel obstruction. In: Greenfield LJ, Mulholland MW, eds. Surgery: Scientific Principles and Practice. Philadelphia, Pa.: Lippincott-Raven, 1997:817–31.

36. Maglinte DD, Reyes BL, Harmon BH, Kelvin FM, Turner WW Jr, Hage JE, et al. Reliability and role of plain film radiography and CT in the diagnosis of small-bowel obstruction. AJR Am J Roentgenol. 1996;167:1451–5.

37. Avots-Avotins KV, Waugh DE. Colon volvulus and the geriatric patient. Surg Clin North Am. 1982;62:249–60.

38. Powell JT, Greenhalgh RM. Clinical practice. Small abdominal aneurysms. N Engl J Med. 2003;348:1895–901.

39. Lederle FA, Johnson GR, Wilson SE, Chute EP, Littooy FN, Bandyk D, et al. Prevalence and associations of abdominal aortic aneurysm detected through screening. Aneurysm Detection and Management (ADAM) Veterans Affairs Cooperative Study Group. Ann Intern Med. 1997;126:441–9.

40. Wilmink TB, Quick CR, Day NE. The association between cigarette smoking and abdominal aortic aneurysms. J Vasc Surg. 1999;30:1099–105.

41. U.S. Preventive Services Task Force. Screening for abdominal aortic aneurysm: recommendation statement. Rockville, Md.: Agency for Healthcare Research and Quality, 2005. Accessed March 15, 2006, at: http://www.ahrq.gov/clinic/uspstf05/aaascr/aaars.pdf.

42. Fielding JW, Black J, Ashton F, Slaney G, Campbell DJ. Diagnosis and management of 528 abdominal aortic aneurysms. Br Med J (Clin Res Ed). 1981;283:355–9.

43. Marston WA, Ahlquist R, Johnson G Jr, Meyer AA. Misdiagnosis of ruptured abdominal aortic aneurysms. J Vasc Surg. 1992;16:17–22.

44. Ruotolo RA, Evans SR. Mesenteric ischemia in the elderly. Clin Geriatr Med. 1999;15:527–57.

45. Greenwald DA, Brandt LJ, Reinus JF. Ischemic bowel disease in the elderly. Gastroenterol Clin North Am. 2001;30:445–73.


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