Letters to the Editor

Diagnosis and Treatment of Group A Pharyngitis Strep


Am Fam Physician. 2005 Mar 15;71(6):1064-1066.

to the editor: The article1 on pharyngitis by Vincent and colleagues raises several questions about their approach to diagnosis and treatment of group A beta-hemolytic streptococcal pharyngitis.

They report the sensitivity and specificity of throat culture as 97 and 99 percent, respectively, for diagnosing group A beta-hemolytic streptococci, citing McIsaac’s article,2 which seems to be higher than reported in the literature. McIsaac and colleagues2 compared the sensitivity and specificity of a score-based approach to the diagnosis of sore throat in their population as compared to throat culture, but did not provide the sensitivity and specificity of throat culture in their article. Perhaps a more accurate estimate comes from the study by Gerber and colleagues.3 The sensitivity and specificity of culture is reported as 78 and 99 percent, respectively. Similarly, in an article published in American Family Physician, Hayes and colleagues4 state that under ideal conditions, the sensitivity of throat culture for group A beta-hemolytic streptococci is only 90 percent; in office settings, the sensitivity ranges from 29 to 90 percent.4 The specificity of throat culture is 99 percent under ideal conditions and can be anywhere from 76 to 99 percent in office settings.4

The authors also recommend obtaining cultures if symptoms do not improve, citing the article by Attia.5 Attia and colleagues sought to determine the performance of a predictive model for group A beta-hemolytic streptococcal pharyngitis and did not recommend follow-up cultures if symptoms do not improve.5 We fail to understand the reasons for obtaining cultures in these patients as shown in Figure 1 of the article1 by Vincent and colleagues because some of these patients have already been treated based on rapid strep test results. It is unclear whether they intend to identify bacteriologic failures, relapse, or reinfection.


show all references

1. Vincent MT, Celestin N, Hussain AN. Pharyngitis. Am Fam Physician. 2004;69:1465–70....

2. McIsaac WJ, Goel V, To T, Low DE. The validity of a sore throat score in family practice. CMAJ. 2000;163:811–5.

3. Gerber MA, Tanz RR, Kabat W, Dennis E, Bell GL, Kaplan EL, et al. Optical immunoassay test for group A beta-hemolytic streptococcal pharyngitis. An office-based, multicenter investigation. JAMA. 1997;277:899–903.

4. Hayes CS, Williamson H Jr. Management of Group A beta-hemolytic streptococcal pharyngitis [published correction appears in Am Fam Physician 2002;65:1282]. Am Fam Physician. 2001;63:1557–64.

5. Attia MW, Zaoutis T, Klein JD, Meier FA. Performance of a predictive model for streptococcal pharyngitis in children [published correction appears in Arch Pediatr Adolesc Med 2001; 155:1179]. Arch Pediatr Adolesc Med. 2001;155:687–91.

in reply: Drs. Singh and Dolan raise the question of the sensitivity of throat culture to diagnose streptococcal pharyngitis and reinforce the importance of obtaining the specimen under “ideal conditions.” In our article,1 we recognized the significance and described the proper technique for obtaining a throat culture under the subsection “Laboratory Evaluation” and state in Table 1 a sensitivity of “97 percent results dependent on the technique, medium, and incubation.”2 Several of the references that support a sensitivity greater than 90 percent of throat culture for the diagnosis of group A beta-hemolytic streptococcus report a sensitivity of 90 to 97 percent when performed properly.25 A question also is raised about the necessity of obtaining a throat culture in the subset of patients who do not improve following treatment. Bisno and colleagues2 state that these patients require reculture to identify treatment failures, reinfection, or relapse.


show all references

1. Vincent MT, Celestin N, Hussain AN. Pharyngitis. Am Fam Physician. 2004;69:1465–70....

2. Bisno AL, Gerber MA, Gwaltney JM Jr, Kaplan EL, Schwartz RH, Infectious Diseases Society of America. Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Clin Infect Dis. 2002;35:113–25.

3. Gerber MA. Diagnosis of group A streptococcal pharyngitis. Pediatr Ann. 1998;27:269–73.

4. Bisno AL. Acute pharyngitis. N Engl J Med. 2001;344:205–11.

5. Pitetti RD, Wald ER. Strep throat: considering the diagnostic options. Patient Care. 1999;33:119–45.

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This series is coordinated by Kenny Lin, MD, MPH, Associate Deputy Editor for AFP Online.



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