Practice Guidelines

ACIP Releases 2017 Childhood Immunization Recommendations


Key Points for Practice

• Infants should receive their first dose of hepatitis B vaccine within 24 hours of birth.

• Two doses of human papillomavirus vaccine administered at zero and then 6 to 12 months is recommended for adolescents who begin the series before 15 years of age.

• The recommendations for both meningococcal vaccines apply regardless of human immunodeficiency virus status or CD4 count in children and adolescents.

• In low-risk adolescents, serogroup B meningococcal vaccine may be given as a two-dose series.

• High-risk medical conditions may require altered vaccine schedules.

From the AFP Editors

The Advisory Committee on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention reviews and updates the childhood immunization schedule annually to reflect recently published updates or corrections from the previous year. The 2017 childhood immunization schedule is available at This year's schedule features a new table and several key recommendation changes.

General Recommendations

The ACIP continues to recommend that any dose not given at the recommended age be given at the next possible opportunity. In general, using combination vaccines is preferred over separate injections of equivalent component vaccines. Clinically significant adverse events that follow vaccination should be reported to the Vaccine Adverse Event Reporting System online ( or via telephone (800-822-7967).

Human Papillomavirus Vaccine

A two-dose human papillomavirus vaccine series (zero, six to 12 months) is recommended for adolescents who begin the series before 15 years of age. Routine vaccination at 11 to 12 years of age is recommended. To be considered immunized, five or more months must have passed between the first and second doses of vaccine, otherwise a third dose should be given at six months. For adolescents who receive the first dose before 15 years of age but

Address correspondence to Margot Savoy, MD, MPH, at Reprints are not available from the author.

Author disclosure: No relevant financial affiliations.


1. Meites E, Kempe A, Markowitz LE. Use of a 2-dose schedule for human papillomavirus vaccination—updated recommendations of the Advisory Committee on Immunization Practices. MMWR Morb Mortal Wkly Rep. 2016;65(49):1405–1408.

2. Grohskopf LA, Sokolow LZ, Broder KR, et al. Prevention and control of seasonal influenza with vaccines. MMWR Recomm Rep. 2016;65(5):1–54.

3. MacNeil JR, Rubin LG, Patton M, Ortega-Sanchez IR, Martin SW. Recommendations for use of meningococcal conjugate vaccines in HIV-infected persons—Advisory Committee on Immunization Practices, 2016. MMWR Morb Mortal Wkly Rep. 2016;65(43):1189–1194.

Coverage of guidelines from other organizations does not imply endorsement by AFP or the AAFP.

This series is coordinated by Sumi Sexton, MD, Associate Deputy Editor.

A collection of Practice Guidelines published in AFP is available at



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Feb 15, 2018

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