Hoarseness in Adults

 

Am Fam Physician. 2017 Dec 1;96(11):720-728.

Author disclosure: No relevant financial affiliations.

Hoarseness is a common presentation in primary care practices. Combined with other voice-related changes, it falls under the umbrella diagnosis of dysphonia. Hoarseness has a number of causes, ranging from simple inflammatory processes to less common psychiatric disorders to more serious systemic, neurologic, or cancerous conditions. Medication-induced hoarseness is common and should be considered. The initial evaluation begins with a targeted history and physical examination, while also looking for signs of potential systemic etiologies. Treatment should begin with voice rest, especially avoidance of whispering, and conservative management directed toward a presumptive cause. For example, proton pump inhibitors are appropriate for hoarseness due to reflux, and proper vocal hygiene is recommended for vocal abuse–related indications. In the absence of a clear indication, antibiotics, oral corticosteroids, and proton pump inhibitors should not be used for the empiric treatment of hoarseness. Direct visualization of the larynx and vocal folds, commonly mislabeled as vocal cords, should be performed within three months if an etiology has not been determined or if conservative management has been ineffective. Patients who experience symptoms lasting longer than two weeks and who have risk factors for dysplasia (e.g., tobacco use, heavy alcohol use, hemoptysis) may require earlier laryngoscopic evaluation. Voice therapy is effective for improving voice quality in patients with dysphonia if conservative measures are unsuccessful, and it can also be helpful for prophylaxis in high-risk individuals (e.g., vocalists, public speakers). Surgical management is indicated for laryngeal or vocal fold dysplasia or malignancy, airway obstruction, or benign pathology resistant to conservative treatment.

Hoarseness is a common symptom in adults, with a lifetime prevalence of 30% and a point prevalence of 7% for adults 65 years and younger. Most never seek treatment, with only 6% of patients presenting to a health care professional.1 However, hoarseness still constitutes a common out-patient concern and can significantly impact patients' voice-related quality of life and limit their productivity.2

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SORT: KEY RECOMMENDATIONS FOR PRACTICE

Clinical recommendationEvidence ratingReferences

Examination of the larynx by direct or indirect laryngoscopy should be performed on patients with hoarseness lasting longer than two weeks without an apparent benign etiology.

C

3

In the absence of signs and symptoms suggestive of an underlying cause, antibiotics, oral corticosteroids, and proton pump inhibitors should not be used for the empiric treatment of laryngitis/hoarseness.

C

3

If laryngopharyngeal or gastroesophageal reflux is suspected, consider a trial of a high-dose proton pump inhibitor for three to four months.

C

26

Voice therapy is effective for improving voice quality and vocal performance in patients with nonorganic dysphonia.

A

20

Voice therapy is effective for treating benign vocal fold nodules, polyps, cysts, and granulomas.

B

2931

Vocal hygiene education is effective for treating patients with hoarseness.

B

29, 32


A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to https://www.aafp.org/afpsort.

SORT: KEY RECOMMENDATIONS FOR PRACTICE

Clinical recommendationEvidence ratingReferences

Examination of the larynx by direct or indirect laryngoscopy should be performed on patients with hoarseness lasting longer than two weeks without an apparent benign etiology.

C

3

In the absence of signs and symptoms suggestive of an underlying cause, antibiotics, oral corticosteroids, and proton pump inhibitors should not be used for the empiric treatment of laryngitis/hoarseness.

C

3

If laryngopharyngeal or gastroesophageal reflux is suspected, consider a trial of a high-dose proton pump inhibitor for three to four months.

C

26

Voice therapy is effective for improving voice quality and vocal performance in patients with nonorganic dysphonia.

A

20

Voice therapy is effective for treating benign vocal fold nodules, polyps, cysts, and granulomas.

B

2931

Vocal hygiene education is effective for treating patients with hoarseness.

B

29, 32


A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to https://www.aafp.org/afpsort.

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BEST PRACTICES IN OTOLARYNGOLOGY: RECOMMENDATIONS FROM THE CHOOSING WISELY CAMPAIGN

RecommendationSponsoring organization

Do not perform computed tomography or magnetic resonance imaging in patients with a primary complaint of hoarseness before examining the larynx.

American Academy of Otolaryngology–Head and Neck Surgery Foundation


Source: For more information on the Choosing Wisely Campaign, see http://www.choosingwisely.org. For supporting citations and to search Choosing Wisely recommendations relevant to primary care, see https://www.aafp.org/afp/recommendations/search.htm.

BEST PRACTICES IN OTOLARYNGOLOGY: RECOMMENDATIONS FROM THE CHOOSING WISELY CAMPAIGN

RecommendationSponsoring organization

Do not perform computed tomography or magnetic resonance imaging in patients with a primary complaint of hoarseness before examining the larynx.

American Academy of Otolaryngology–Head and Neck Surgery Foundation


Source: For more information on the Choosing Wisely Campaign, see http://www.choosingwisely.org. For supporting citations and to search Choosing Wisely recommendations relevant to primary care, see https://www.aafp.org/afp/recommendations/search.htm.

The term hoarseness is commonly used to describe any change in voice but more specifically refers to a coarse, rough, raspy, or strangled vocal quality. It includes any change in pitch, loudness, or vocal effort that impairs vocal function. The presence of hoarseness warrants investigation to determine an underlying cause.3

Laryngeal Anatomy and Function

The larynx functions in vocalization, deglutition, and respiration. It consists of an inner, mucosal-lined soft tissue framework protected by cartilaginous and bony structures (Figure 1).4 Extending from tongue base to trachea, it can be divided into three sections: supraglottic, glottic, and subglottic. The supraglottis, protected by the hyoid bone and thyroid cartilage, ranges from the tongue base to just above the true vocal folds (commonly mislabeled as vocal cords), and contains the epiglottis, false vocal folds, and arytenoids. The glottis, protected by the thyroid cartilage, extends inferiorly 1 cm below the true vocal folds. The subglottis extends from the inferior glottis to just below the cricoid cartilage.

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Figure 1.

Laryngeal anatomy. (Left) Posterior view of larynx, and (right) cross-section of larynx from above.

Reprinted with permission from Feierabend RH, Malik SN. Hoarseness in adults. Am Fam Physician . 2009;80(4):364.


Figure 1.

Laryngeal anatomy. (Left) Posterior view of larynx, and (right) cross-section of larynx from above.

Reprinted with permission from Feierabend RH, Malik SN. Hoarseness in adults. Am Fam Physician . 2009;80(4):364.

The larynx contains extrinsic and intrinsic muscles innervated by two nerves branching from the vagus on each side: the superior laryngeal nerve and the recurrent (or inferior) laryngeal nerve. The internal branch of the superior laryngeal nerve enters the supraglottis between the hyoid and thyroid cartilage, and the external branch enters the glottis laterally through the cricothyroid membrane. The recurrent laryngeal nerves ascend lateral to the trachea after recurring upward around the aortic arch on the left and the subclavian artery on the right to ultimately enter the glottis through the cricothyroid membrane. The extrinsic muscles elevate and lower the position of the larynx in the neck. The intrinsic muscles produce fine movements of the vocal folds for phonation, and except for the cricothyroid muscles, are innervated by the recurrent laryngeal nerves.

The larynx produces sounds by forcing air through partially closed vocal folds to create vibrations of the folds. The intrinsic muscles control the tension of the vocal folds to create a wide range of sound waves, and the positioning of other speech organs such as the lips, tongue, and soft palate modifies these waves to increase the range of sounds.

Causes of Hoarseness

Dysphonia (i.e., voice impairment) can result from any pathology affecting these complex mechanisms of vocalization, but hoarseness primarily results from vocal fold changes. Causes of hoarseness can be grouped into four categories: irritant/inflammatory, neoplastic, neuromuscular/psychiatric, and associated systemic disease. Common and important causes are listed in Table 1.4

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Table 1.

Common or Important Causes of Hoarseness

Inflammatory or irritant

Allergies and irritants (alcohol, tobacco)

Direct trauma (intubation)

Environmental irritants

Infections (upper respiratory infection, fungal laryngitis)

Laryngopharyngeal or gastroesophageal reflux

Medications

Vocal abuse

Neoplasia or physical lesions

Benign vocal fold lesions

Dysplasia

Laryngeal papillomatosis

Squamous cell carcinoma

Neuromuscular and psychiatric

Age-related vocal atrophy

Multiple sclerosis

Muscle tension dysphonia

Myasthenia gravis

Nerve injury (vagus or recurrent laryngeal nerve)

Parkinson disease

Psychogenic (including conversion aphonia)

Spasmodic dysphonia (laryngeal dystonia)

Stroke

Associated systemic diseases

Acromegaly

Amyloidosis

Hypothyroidism

Inflammatory arthritis

Lupus

Sarcoidosis


Adapted with permission from Feierabend RH, Malik SN. Hoarseness in adults. Am Fam Physician. 2009;80(4):365.

Table 1.

Common or Important Causes of Hoarseness

Inflammatory or irritant

Allergies and irritants (alcohol, tobacco)

Direct trauma (intubation)

Environmental irritants

Infections (upper respiratory infection, fungal laryngitis)

Laryngopharyngeal or gastroesophageal reflux

Medications

Vocal abuse

Neoplasia or physical lesions

Benign vocal fold lesions

Dysplasia

Laryngeal papillomatosis

Squamous cell carcinoma

Neuromuscular and psychiatric

Age-related vocal atrophy

Multiple sclerosis

Muscle tension dysphonia

Myasthenia gravis

Nerve injury (vagus or recurrent laryngeal nerve)

Parkinson disease

Psychogenic (including conversion aphonia)

Spasmodic dysphonia (laryngeal dystonia)

Stroke

Associated systemic diseases

Acromegaly

Amyloidosis

Hypothyroidism

Inflammatory arthritis

Lupus

Sarcoidosis


Adapted with permission from Feierabend RH, Malik SN. Hoarseness in adults. Am Fam Physician. 2009;80(4):365.

INFLAMMATORY AND IRRITANT CAUSES

The most common cause of hoarseness in adults is laryngitis, which is classified as acute or chronic. Acute laryngitis is a common, self-limited condition lasting less than three to four weeks. Common causes include acute vocal strain or upper respiratory infection. Short-term vocal abuse (e.g., singing, screaming) or protracted coughing can cause microtrauma and focal vocal fold edema. Hoarseness is often part of a constellation of upper respiratory symptoms caused by viruses and less commonly by bacterial or fungal sources.5 Allergic rhinitis is another common cause of acute laryngitis.

Chronic laryngitis is diagnosed when symptoms persist for more than three to four weeks. Long-term inhalation of irritants (usually through smoking), reflux, chronic vocal strain, and postnasal drip are common causes. Irritation of vocal fold mucosa by reflux can be caused by laryngopharyngeal reflux (LPR) or gastroesophageal reflux disease (GERD). Medications are another common cause of chronic laryngitis,69  particularly those classes listed in Table 2.3

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Table 2.

Medications That May Cause Hoarseness

MedicationMechanism of impact on voice

Angiotensin-converting enzyme inhibitors

Cough

Antihistamines, diuretics, anticholinergics

Drying effect on mucosa

Antipsychotics, including atypical antipsychotics

Laryngeal dystonia

Bisphosphonates

Chemical laryngitis

Danazol, testosterone

Sex hormone production/utilization alteration

Inhaled corticosteroids

Dose-dependent mucosal irritation, candidal or fungal laryngitis

Warfarin (Coumadin), thrombolytics, phosphodiesterase-5 inhibitors

Vocal fold hematoma


Adapted with permission from Schwartz SR, Cohen SM, Dailey SH, et al. Clinical practice guideline: hoarseness (dysphonia). Otolaryngol Head Neck Surg. 2009;141(3 suppl 2):S9.

Table 2.

Medications That May Cause Hoarseness

MedicationMechanism of impact on voice

Angiotensin-converting enzyme inhibitors

Cough

Antihistamines, diuretics, anticholinergics

Drying effect on mucosa

Antipsychotics, including atypical antipsychotics

Laryngeal dystonia

Bisphosphonates

Chemical laryngitis

Danazol, testosterone

Sex hormone production/utilization alteration

Inhaled corticosteroids

Dose-dependent mucosal irritation, candidal or fungal laryngitis

Warfarin (Coumadin), thrombolytics, phosphodiesterase-5 inhibitors

Vocal fold hematoma


Adapted with permission from Schwartz SR, Cohen SM, Dailey SH, et al. Clinical practice guideline: hoarseness (dysphonia). Otolaryngol Head Neck Surg. 2009;141(3 suppl 2):S9.

NEOPLASIA AND PHYSICAL LESIONS

Vocal fold lesions may be benign or malignant. More common benign lesions include Reinke edema (also known as polypoid chorditis), cysts, pseudocysts, polyps, and nodules (also known as midfold masses).10  Some benign lesions have a higher prevalence based on factors such as age and sex (Table 3).1013

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Table 3.

Characteristics of Benign Vocal Fold Lesions

Lesion typeLaryngoscopic findingsCommon characteristics and associationsEtiologies

Bilateral midfold masses (includes nodules)

Subepithelial fibrous thickening at vocal fold midpoint

Female, 18 to 39 years of age

Vocal abuse

Contact lesion (ulceration or granuloma)

Mucosal irregularity over vocal process of arytenoid cartilage

Male, unilateral or bilateral

Direct trauma (intubation), inhaled corticosteroid use, LPR, vocal abuse

Cyst

Encapsulated subepithelial mass

Unilateral

Vocal abuse

Hemorrhage

Subepithelial extravasated blood

Unilateral

Vocal abuse, direct trauma, anticoagulant use

Leukoplakia

White-appearing epithelia of vocal fold

Male, older age (60 years and older)

Benign leukoplakia, carcinoma, dysplasia

Polyp

Well-defined sessile or pedunculated midpoint mass

Male, unilateral

Allergy, tobacco and other irritants, vocal abuse

Pseudocyst

Translucent lesion on vibratory margin

Female, 18 to 39 years of age, unilateral

Vocal abuse, vocal fold paresis

Reactive lesion

Focal mucosal thickening in vocal fold midpoint

Unilateral, contralateral lesion

Trauma by contralateral vocal fold lesion

Reinke edema (polypoid chorditis)

Proliferation of superficial mucosa over entire length of one or both vocal folds

Female, middle-aged (40 to 59 years) or older age (60 years and older), bilateral more common

GERD, LPR, tobacco and other irritants, vocal abuse

Sulcus

Focal epithelial invagination

Male, bilateral

Congenital

Unilateral midfold masses (includes nodules)

Subepithelial fibrous thickening at vocal fold midpoint

Male, less common than bilateral

Vocal abuse


GERD = gastroesophageal reflux disease; LPR = laryngopharyngeal reflux.

Information from references 10 through 13.

Table 3.

Characteristics of Benign Vocal Fold Lesions

Lesion typeLaryngoscopic findingsCommon characteristics and associationsEtiologies

Bilateral midfold masses (includes nodules)

Subepithelial fibrous thickening at vocal fold midpoint

Female, 18 to 39 years of age

Vocal abuse

Contact lesion (ulceration or granuloma)

Mucosal irregularity over vocal process of arytenoid cartilage

Male, unilateral or bilateral

Direct trauma (intubation), inhaled corticosteroid use, LPR, vocal abuse

Cyst

Encapsulated subepithelial mass

Unilateral

Vocal abuse

Hemorrhage

Subepithelial extravasated blood

Unilateral

Vocal abuse, direct trauma, anticoagulant use

Leukoplakia

White-appearing epithelia of vocal fold

Male, older age (60 years and older)

Benign leukoplakia, carcinoma, dysplasia

Polyp

Well-defined sessile or pedunculated midpoint mass

Male, unilateral

Allergy, tobacco and other irritants, vocal abuse

Pseudocyst

Translucent lesion on vibratory margin

Female, 18 to 39 years of age, unilateral

Vocal abuse, vocal fold paresis

Reactive lesion

Focal mucosal thickening in vocal fold midpoint

Unilateral, contralateral lesion

Trauma by contralateral vocal fold lesion

Reinke edema (polypoid chorditis)

Proliferation of superficial mucosa over entire length of one or both vocal folds

Female, middle-aged (40 to 59 years) or older age (60 years and older), bilateral more common

GERD, LPR, tobacco and other irritants, vocal abuse

Sulcus

Focal epithelial invagination

Male, bilateral

Congenital

Unilateral midfold masses (includes nodules)

Subepithelial fibrous thickening at vocal fold midpoint

Male, less common than bilateral

Vocal abuse


GERD = gastroesophageal reflux disease; LPR = laryngopharyngeal reflux.

Information from references 10 through 13.

Premalignant or malignant vocal fold lesions include laryngeal leukoplakia, dysplasia, and squamous cell carcinoma. Smoking, alcohol abuse, LPR, and GERD are risk factors for more serious underlying causes such as malignant lesions.3 Hoarseness alone or other related symptoms (e.g., dysphagia, odynophagia, otalgia, hemoptysis, unilateral throat pain) may be the initial presentation of these lesions, particularly in middle-aged or older persons who smoke.3,14,15

NEUROMUSCULAR AND PSYCHIATRIC CAUSES

Vocal fold paralysis is a common neurologic cause of hoarseness. Unilateral paralysis is typically caused by recurrent laryngeal nerve injury during neck, thyroid, or cardiothoracic surgery, but many times it is idiopathic.16 Unilateral paralysis can also be associated with infiltrating thyroid or apical lung cancers.12,13 Bilateral vocal fold paralysis is typically associated with bilateral thyroid surgery or neck trauma resulting in bilateral recurrent laryngeal nerve injury. Prolonged or traumatic endotracheal intubation can cause vocal fold inflammation and paralysis. Presbylaryngis, or age-related vocal atrophy, is increasingly common with an aging population, and can mimic fold paralysis as laryngeal muscles atrophy despite intact innervation.17 Less common neurologic causes include myasthenia gravis, Parkinson disease, amyotrophic lateral sclerosis, and multiple sclerosis.

Spasmodic dysphonia (or laryngeal dystonia) is the episodic, uncontrolled contraction of laryngeal intrinsic muscles to create a halting, strangled voice. Once considered psychogenic because of its relation to stress, the underlying neuromuscular etiology remains unknown.18 Considered neuropsychiatric in nature, muscle tension dysphonia results from excessive tension of the intrinsic or extrinsic muscles, and is associated with lack of breath control and stress.19 Psychiatric or functional voice disorders include functional dysphonia, laryngeal conversion disorder, paradoxical vocal fold motion, and malingering. Functional dysphonia occurs in patients with job-related chronic vocal stress without organic cause. Conversion disorder and paradoxical fold motion are psychogenic responses to stress.20

ASSOCIATED SYSTEMIC DISEASES

Less commonly, hoarseness occurs secondary to systemic illnesses. Autoimmune diseases, such as inflammatory arthritis and lupus, can affect the cricoarytenoid joints. Endocrine disorders, including hypothyroidism and acromegaly, can cause hoarseness. Sarcoidosis and laryngeal amyloidosis are rare etiologies that strain voice quality from infiltration of the vocal folds and supraglottic structures.21

Evaluation of Hoarseness

HISTORY AND PHYSICAL EXAMINATION

The first step in evaluating hoarseness should be assessing vocal quality, speech effort, or signs of pain with speaking or swallowing, followed by the history, including specific changes in vocal quality (Table 4).4 Timing, onset, duration, and exacerbating or remitting factors can be key to determining the etiology. The presence of any associated symptoms, especially for GERD, LPR, or postnasal drip, should be elicited. Symptoms of LPR include dysphagia, burning in the throat, globus sensation, throat clearing, or a sensation of postnasal drainage. GERD and LPR can occur together or separately. A review of medications is imperative because multiple drug classes have been associated with dysphonia9  (Table 2 3). Acute onset is more suggestive of infection, inflammation, injury, or vocal abuse (e.g., singing or screaming at a sporting event or concert), whereas a chronic or progressive change in phonation can indicate more severe illness.

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Table 4.

Clinical Clues Suggesting Specific Causes of Hoarseness: Vocal Quality

Vocal qualitySuggested diagnoses

Breathy

Inflammatory arthritis, spasmodic or functional dysphonia, vocal fold mass, vocal fold paralysis

Halting, strangled

Spasmodic dysphonia

Hoarse, husky, muffled, or nasal-sounding

Parkinson disease

Hoarseness worse early in the day

GERD, LPR

Hoarseness worse later in the day

Myasthenia gravis, vocal abuse

Low pitched

GERD, hypothyroidism, LPR, leukoplakia, muscle tension dysphonia, Reinke edema, vocal fold edema, age-related vocal atrophy in women

Raspy or harsh

GERD, LPR, muscle tension dysphonia, vocal fold lesion

Scanning speech and dysarthria

Multiple sclerosis

Soft (loss of volume)

Vocal fold paralysis, Parkinson disease, age-related vocal atrophy

Spoken voice lost, but whispered voice maintained

Conversion aphonia

Strained

GERD, LPR, muscle tension dysphonia, spasmodic dysphonia

Strained, effortful phonation

Muscle tension dysphonia

Thick, deep voice and slowed speech

Acromegaly

Vocal fatigue

Muscle tension dysphonia, myasthenia gravis, Parkinson disease, vocal abuse, age-related vocal atrophy


GERD = gastroesophageal reflux disease; LPR = laryngopharyngeal reflux.

Adapted with permission from Feierabend RH, Malik SN. Hoarseness in adults. Am Fam Physician. 2009;80(4):366.

Table 4.

Clinical Clues Suggesting Specific Causes of Hoarseness: Vocal Quality

Vocal qualitySuggested diagnoses

Breathy

Inflammatory arthritis, spasmodic or functional dysphonia, vocal fold mass, vocal fold paralysis

Halting, strangled

Spasmodic dysphonia

Hoarse, husky, muffled, or nasal-sounding

Parkinson disease

Hoarseness worse early in the day

GERD, LPR

Hoarseness worse later in the day

Myasthenia gravis, vocal abuse

Low pitched

GERD, hypothyroidism, LPR, leukoplakia, muscle tension dysphonia, Reinke edema, vocal fold edema, age-related vocal atrophy in women

Raspy or harsh

GERD, LPR, muscle tension dysphonia, vocal fold lesion

Scanning speech and dysarthria

Multiple sclerosis

Soft (loss of volume)

Vocal fold paralysis, Parkinson disease, age-related vocal atrophy

Spoken voice lost, but whispered voice maintained

Conversion aphonia

Strained

GERD, LPR, muscle tension dysphonia, spasmodic dysphonia

Strained, effortful phonation

Muscle tension dysphonia

Thick, deep voice and slowed speech

Acromegaly

Vocal fatigue

Muscle tension dysphonia, myasthenia gravis, Parkinson disease, vocal abuse, age-related vocal atrophy


GERD = gastroesophageal reflux disease; LPR = laryngopharyngeal reflux.

Adapted with permission from Feierabend RH, Malik SN. Hoarseness in adults. Am Fam Physician. 2009;80(4):366.

Patients should be asked about voice use and other related symptoms and factors (Table 5).4 For example, do they use their voice frequently in their occupation (e.g., singing, public speaking, telemarketing, teaching) or recreation (e.g., umpiring, coaching)? Is their voice change constant, progressive, or relapsing/remitting? 4

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Table 5.

Clinical Clues Suggesting Specific Causes of Hoarseness: History and Physical Examination

FindingsSuggested causes

Cough

Allergy, GERD, inhaled irritants, LPR, tobacco, URI

Dysphagia

Carcinoma, GERD, inflammatory arthritis, LPR

Heartburn

Carcinoma, GERD, LPR

Hemoptysis

Carcinoma

History of heavy alcohol use

Carcinoma, GERD, LPR

History of smoking or tobacco use

Carcinoma, chronic laryngitis, leukoplakia, Reinke edema

Odynophagia

Carcinoma, inflammatory arthritis, URI

Palpable lymph nodes

Carcinoma, URI

Professional vocalist or untrained singer

Vocal abuse

Recent head, neck, or chest surgery

Vagus or recurrent laryngeal nerve injury

Recent intubation or laryngeal procedure

Direct trauma with vocal fold paralysis

Rhinorrhea, sneezing, watery eyes

Allergy, URI

Sensitivity to heat, spicy foods, other irritants

Leukoplakia

Stridor, symptoms of airway obstruction

Carcinoma, laryngeal papillomatosis

Throat clearing

Allergy, GERD, inhaled corticosteroids, LPR

Weight loss

Carcinoma

Wheezing, other signs of asthma

Allergy, inhaled corticosteroids


GERD = gastroesophageal reflux disease; LPR = laryngopharyngeal reflux; URI = upper respiratory infection.

Adapted with permission from Feierabend RH, Malik SN. Hoarseness in adults. Am Fam Physician. 2009;80(4):367.

Table 5.

Clinical Clues Suggesting Specific Causes of Hoarseness: History and Physical Examination

FindingsSuggested causes

Cough

Allergy, GERD, inhaled irritants, LPR, tobacco, URI

Dysphagia

Carcinoma, GERD, inflammatory arthritis, LPR

Heartburn

Carcinoma, GERD, LPR

Hemoptysis

Carcinoma

History of heavy alcohol use

Carcinoma, GERD, LPR

History of smoking or tobacco use

Carcinoma, chronic laryngitis, leukoplakia, Reinke edema

Odynophagia

Carcinoma, inflammatory arthritis, URI

Palpable lymph nodes

Carcinoma, URI

Professional vocalist or untrained singer

Vocal abuse

Recent head, neck, or chest surgery

Vagus or recurrent laryngeal nerve injury

Recent intubation or laryngeal procedure

Direct trauma with vocal fold paralysis

Rhinorrhea, sneezing, watery eyes

Allergy, URI

Sensitivity to heat, spicy foods, other irritants

Leukoplakia

Stridor, symptoms of airway obstruction

Carcinoma, laryngeal papillomatosis

Throat clearing

Allergy, GERD, inhaled corticosteroids, LPR

Weight loss

Carcinoma

Wheezing, other signs of asthma

Allergy, inhaled corticosteroids


GERD = gastroesophageal reflux disease; LPR = laryngopharyngeal reflux; URI = upper respiratory infection.

Adapted with permission from Feierabend RH, Malik SN. Hoarseness in adults. Am Fam Physician. 2009;80(4):367.

The physical examination should be guided by the history and important causes (Tables 1, 4, and 5) with attention to the head and neck examinations.4

OTHER DIAGNOSTIC STUDIES

Hoarseness of acute onset with a duration of less than 14 days and an apparent benign cause requires no further initial evaluation. Laryngoscopy should be performed if serious pathology is suspected, or it can be considered if dysphonia persists longer than two weeks, especially in patients with risk factors for dysplasia such as tobacco use, heavy alcohol use, or hemoptysis.3  Visualization by direct or indirect methods should not be delayed beyond three months for patients who remain symptomatic. Table 31013  and Table 6 4 highlight laryngoscopic findings for a variety of conditions. Figure 2 outlines a suggested approach to the primary care management of hoarseness.4 Referral for imaging studies (computed tomography or magnetic resonance imaging) or biopsy may be indicated if laryngoscopy is nondiagnostic.3 Laryngoscopy and pH monitoring are not reliable tests for diagnosing LPR. Videostroboscopy, which uses strobe lighting during laryngoscopy, can further visualize mucosal vibration disorders (e.g., scar, sulcus) if conventional laryngoscopy is inconclusive.22,23 Speech-language pathology offers perceptual, acoustic, and aerodynamic evaluations if examination and imaging are insufficient for making a diagnosis.24

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Table 6.

Laryngoscopic Findings Associated with Causes of Hoarseness

FindingsEtiologies

Cysts

Vocal abuse

Exophytic or ulcerated lesions

Carcinoma

Granulomas

Direct trauma (intubation), GERD, inhaled corticosteroids, LPR, vocal abuse

Laryngeal inflammation

Allergy, direct trauma (intubation), GERD, infection, inhaled corticosteroids, LPR, tobacco and other irritants

Leukoplakia

Benign leukoplakia, carcinoma, dysplasia

Loss of vocal fold adduction during phonation, but normal adduction with coughing or throat clearing

Conversion aphonia

Nodules

Vocal abuse

Papillomas

Laryngeal papillomatosis (human papillomavirus infection)

Polyps

Allergy, tobacco and other irritants, vocal abuse

Reinke edema (polypoid chorditis)

GERD, LPR, tobacco and other irritants, vocal abuse

Translucent, yellow, waxy deposits on vocal folds

Laryngeal amyloidosis

Ulceration and laceration

Direct trauma (intubation)

Vocal fold in paramedian or lateralized position

Vagus or recurrent laryngeal nerve injury, stroke


GERD = gastroesophageal reflux disease; LPR = laryngopharyngeal reflux.

Adapted with permission from Feierabend RH, Malik SN. Hoarseness in adults. Am Fam Physician. 2009;80(4):365.

Table 6.

Laryngoscopic Findings Associated with Causes of Hoarseness

FindingsEtiologies

Cysts

Vocal abuse

Exophytic or ulcerated lesions

Carcinoma

Granulomas

Direct trauma (intubation), GERD, inhaled corticosteroids, LPR, vocal abuse

Laryngeal inflammation

Allergy, direct trauma (intubation), GERD, infection, inhaled corticosteroids, LPR, tobacco and other irritants

Leukoplakia

Benign leukoplakia, carcinoma, dysplasia

Loss of vocal fold adduction during phonation, but normal adduction with coughing or throat clearing

Conversion aphonia

Nodules

Vocal abuse

Papillomas

Laryngeal papillomatosis (human papillomavirus infection)

Polyps

Allergy, tobacco and other irritants, vocal abuse

Reinke edema (polypoid chorditis)

GERD, LPR, tobacco and other irritants, vocal abuse

Translucent, yellow, waxy deposits on vocal folds

Laryngeal amyloidosis

Ulceration and laceration

Direct trauma (intubation)

Vocal fold in paramedian or lateralized position

Vagus or recurrent laryngeal nerve injury, stroke


GERD = gastroesophageal reflux disease; LPR = laryngopharyngeal reflux.

Adapted with permission from Feierabend RH, Malik SN. Hoarseness in adults. Am Fam Physician. 2009;80(4):365.

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Initial Assessment and Management of Hoarseness

Figure 2.

Algorithm for the initial assessment and management of hoarseness.

Adapted with permission from Feierabend RH, Malik SN. Hoarseness in adults. Am Fam Physician . 2009;80(4):368.

Initial Assessment and Management of Hoarseness


Figure 2.

Algorithm for the initial assessment and management of hoarseness.

Adapted with permission from Feierabend RH, Malik SN. Hoarseness in adults. Am Fam Physician . 2009;80(4):368.

Treatment

Voice rest, especially the avoidance of whispering, is essential for the treatment of hoarseness. Neither antibiotics nor corticosteroids should be routinely prescribed empirically.3,25 A three- to four-month regimen of high-dose proton pump inhibitors should be prescribed only if the history indicates GERD or LPR, or if signs of chronic laryngitis are visualized.3,26,27 Inhaled corticosteroids, notably fluticasone (Flovent), budesonide (Rhinocort), and beclomethasone, can cause dysphonia in up to 58% of persons, more so in women (3:2 ratio) and individuals older than 65 years.9,28 Gargling, rinsing the mouth, or drinking water, as well as using a spacer, may be tried if dysphonia develops, and the corticosteroids can be discontinued or given at a reduced dosage if the hoarseness fails to resolve with these simple measures.9

Voice therapy, or voice training, is strongly recommended for patients with hoarseness who have significantly impaired vocal quality of life, especially those with dysphonia of nonorganic origins, benign vocal fold lesions, or age-related vocal atrophy.3,20,24,2932 It can also be preventive in high-risk individuals such as vocalists and public speakers.12,29 Therapy regimens consist of vocal behavior modification to reduce laryngeal trauma during weekly 30- to 60-minute sessions for eight to 10 weeks. Compliance with vocal hygiene (e.g., avoiding irritants and alcohol, using a humidifier, controlling vocal volume, limiting large or spicy meals), vocal and physical exercises, and behavior change are imperative.29,32

Surgical intervention is needed for dysplastic or malignant lesions, airway obstruction, or benign lesions (e.g., nodules, polyps, cysts) that do not respond to conservative therapies. Botulinum toxin can be used for the management of adductor spasmodic dysphonia.33 Vocal fold paralysis can be treated with laryngeal reinnervation or vocal fold medialization procedures.34

This article updates previous articles on this topic by Feierabend and Malik,4 and Rosen, et al.35

Data Sources: A PubMed search was completed using the key terms hoarseness and dysphonia. The search included meta-analyses, randomized controlled trials, clinical trials, reviews, and clinical practice guidelines. Additionally, Essential Evidence Plus, the Cochrane Database of Systematic Reviews, the DynaMed database, and the National Institute for Health and Care Excellence guidelines were used. Search dates: November 30, 2015; March 25, 2016; and May 9, 2017.

The Authors

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STEVEN A. HOUSE, MD, FAAFP, is a professor in the Department of Family and Geriatric Medicine at the University of Louisville (Ky.) School of Medicine, and director of the University of Louisville/Glasgow (Ky.) Family Medicine Residency Program....

ERIC L. FISHER, MD, is an assistant professor in the Department of Family and Geriatric Medicine at the University of Louisville School of Medicine, and assistant medical director at the University of Louisville/Glasgow Family Medicine Residency Program.

Address correspondence to Steven A. House, MD, University of Louisville/Glasgow Family Medicine Residency Program, 1325 North Race St., Glasgow, KY 42141 (e-mail: shouse@tjsamson.org). Reprints are not available from the authors.

Author disclosure: No relevant financial affiliations.

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