Ear Pain: Diagnosing Common and Uncommon Causes

 

Otalgia (ear pain) is a common presentation in the primary care setting with many diverse causes. Pain that originates from the ear is called primary otalgia, and the most common causes are otitis media and otitis externa. Examination of the ear usually reveals abnormal findings in patients with primary otalgia. Pain that originates outside the ear is called secondary otalgia, and the etiology can be difficult to establish because of the complex innervation of the ear. The most common causes of secondary otalgia include temporomandibular joint syndrome and dental infections. Primary otalgia is more common in children, whereas secondary otalgia is more common in adults. History and physical examination usually lead to the underlying cause; however, if the diagnosis is not immediately clear, a trial of symptomatic treatment, imaging studies, and consultation may be reasonable options. Otalgia may be the only presenting symptom in several serious conditions, such as temporal arteritis and malignant neoplasms. When risk factors for malignancy are present (e.g., smoking, alcohol use, diabetes mellitus, age 50 years or older), computed tomography, magnetic resonance imaging, or otolaryngology consultation may be warranted.

Patients with otalgia (ear pain) commonly present to their primary care physician. Pain that originates from the ear is known as primary otalgia, whereas pain that originates outside the ear is secondary otalgia. A comprehensive history and physical examination are essential to determine the etiology of primary or secondary otalgia.

Primary otalgia is more common in children, whereas secondary otalgia is more common in adults.1,2 The etiology of primary otalgia, which is usually identified on examination of the ear, is typically otitis externa or otitis media.3 The etiology of secondary otalgia is more complex because the nerves innervating the ear have a shared distribution to include the head, neck, chest, and abdomen2,4 (Figure 1). The ear is innervated by several sensory nerves. The auricle is affected by cranial nerves V, VII, X, C2, and C3; the external auditory meatus and canal by cranial nerves V, VII, and X; the tympanic membrane by cranial nerves VII, IX, and X; and the middle ear by cranial nerves V, VII, and IX. Irritation of any portion of these nerves can result in otalgia.

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SORT: KEY RECOMMENDATIONS FOR PRACTICE

Clinical recommendationEvidence ratingReferences

The diagnosis of acute otitis media requires moderate to severe bulging of the tympanic membrane, new onset of otorrhea not caused by otitis externa, or mild bulging of the tympanic membrane associated with recent onset of ear pain (less than 48 hours) or erythema.

C

9

Magnetic resonance imaging and referral for nasolaryngoscopy are recommended in the setting of otalgia with normal ear examination findings and symptoms of or risk factors for tumor. Laboratory evaluation with a complete blood count and erythrocyte sedimentation rate can be helpful.

C

2, 14

Patients 50 years and older with otalgia and a normal ear examination should be evaluated for temporal arteritis.

C

14


A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to http://www.aafp.org/afpsort.

SORT: KEY RECOMMENDATIONS FOR PRACTICE

Clinical recommendationEvidence ratingReferences

The diagnosis of acute otitis media requires moderate to severe bulging of the tympanic membrane, new onset of otorrhea not caused by otitis externa, or mild bulging of the tympanic membrane associated with recent onset of ear pain (less than 48 hours) or erythema.

C

9

Magnetic resonance imaging and referral for nasolaryngoscopy are recommended in the setting of otalgia with normal ear examination findings and symptoms of or risk factors for tumor. Laboratory evaluation with a complete blood count and erythrocyte sedimentation rate can be helpful.

C

2, 14

Patients 50 years and older with otalgia and a normal ear examination should be evaluated for temporal arteritis.

C

14


A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to http://www.aafp.org/afpsort.

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FIGURE 1.

Sensory distribution of the nerves innervating the ear. (A) Trigeminal nerve (V): face, sinuses, teeth. (B) Facial nerve (VII): anterior two-thirds of the tongue, soft palate. (C) Glossopharyngeal nerve (IX): posterior one-third of the tongue, tonsils, pharynx, middle ears. (D) Vagus nerve (X): heart, lungs, trachea, bronchi, larynx, pharynx, gastrointestinal tract, middle ears. (E) Cervical nerves 2 and 3 (C2 and C3): external ears, ear canals, anterior region of the neck, posterior region of the neck.

Illustration by Dave Klemm


FIGURE 1.

Sensory distribution of the nerves innervating the ear. (A) Trigeminal nerve (V): face, sinuses, teeth. (B) Facial nerve (VII): anterior two-thirds of the tongue, soft palate. (C) Glossopharyngeal nerve (IX): posterior one-third of the tongue, tonsils, pharynx, middle ears. (D) Vagus nerve (X): heart, lungs, trachea, bronchi, larynx, pharynx, gastrointestinal tract, middle ears. (E) Cervical nerves 2 and 3 (C2 and C3): external ears, ear canals, anterior region of the neck, posterior region of the neck.

Illustration by Dave Klemm

History

To determine the differential diagnosis of otalgia, the following factors should be considered: pain location, duration, aggravating factors, alleviating factors, associated symptoms, previous episodes, medical history, smoking status, and alcohol abuse.5 Symptoms such as otorrhea, tympanic membrane fullness, and vertigo suggest primary otalgia,35 whereas pain with chewing, sinusitis, dental procedures, and a history of gastroesophageal reflux suggest secondary otalgia.46 In adults, the absence of hearing loss is a cardinal finding associated with nonotologic disease.5 The character of pain also provides important clues. Pain that is continuous and progressively worsens is more likely to be associated with infection and primary otalgia. Intermittent pain is likely to be associated with secondary otalgia.2

Physical Examination

The physician should start the examination by asking the patient to localize the pain, which may reveal a secondary cause (e.g., localization to the temporomandibular joint [TMJ], myofascial pain localized to the mastoid process). Physical examination should include inspection of the auricle and periauricular region, as well as an otoscopic examination to visually inspect the tympanic membrane and the external auditory canal. Specific otoscopic examination findings for the etiology of otalgia are listed in Table 15,7  and Table 2.5,8 Detection of a middle ear effusion with moderate to severe bulging of the tympanic membrane, new-onset otorrhea not caused by otitis externa, or mild bulging of the tympanic membrane with recent onset of ear pain (less than 48 hours), especially with erythema, is key in the diagnosis of acute otitis media. The tympanic membrane is normally mobile, translucent, and intact. A tympanic membrane that has normal color and mobility is not typical for acute otitis media.9 Patients with otitis externa typically have pain, redness, swelling, and inflammation along the external auditory canal.

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TABLE 1.

Etiology of Primary Otalgia

EtiologyHistoryPhysical examinationAdditional information

Common causes

Barotrauma

Pain starts while scuba diving or while flying in an airplane; patient may have experienced a recent blast injury

Tympanic membrane can show middle ear hemorrhage

Prevent with use of topical nasal decongestants or autoinflation

Eustachian tube dysfunction

Symptoms of pressure dysregulation

Tympanic membrane retraction or positive tympanographic findings

Also associated with aural fullness and intermittent symptoms7

Foreign object

Commonly insects, small toys, peanuts; most common in children

Foreign object visible in ear canal

May require general anesthesia to remove

Otitis externa

Recent swimming with history of discharge

Pain with pulling on external ear; discharge may be present

More common in summer

Otitis media

Recent upper respiratory tract infection; children may pull on ears

Red, inflamed, cloudy tympanic membrane

Most common cause of ear pain

Uncommon causes

Cellulitis of auricle

Preceding insect bite, scratch, or piercing; rapid progression

Earlobe usually involved

Must treat aggressively; parenteral antibiotics may be required

Cholesteatoma

Sense of fullness

A pearly mass may be visible through the tympanic membrane; often infected with visible squamous material

May be asymptomatic early, but generally associated with hearing loss and otorrhea

Granulomatosis with polyangiitis (Wegener granulomatosis)

Arthralgia, hearing loss, myalgias, oral ulcers, otorrhea, and rhinorrhea

Often with chronic otitis media or serous otitis

Consider testing for antineutrophil cytoplasmic autoantibodies

Malignant otitis externa

Retroauricular pain; often associated with diabetes mellitus and immunocompromised state; consider in persons with no improvement in otitis externa

Granulation tissue may be present in the external auditory canal Lower cranial neuropathies (VII, X, XI, XII)

Easy to miss with subtle findings; technetium bone scan can be used to determine the extent of disease

Mastoiditis

Recent otitis media that is typically chronic but may be acute

Tender edematous mastoids

Uncommon, but prevalence is increased in children with decreased access to health care

Ramsay Hunt syndrome (herpes zoster oticus)

Pain can be present before lesions develop; may be associated with hearing loss, vertigo, or tinnitus

Vesicular rash on auricle or ear canal with possible palsy of cranial nerve VII

Can also involve cranial nerves V, IX, and X; pain can occur without eruption

Relapsing polychondritis

Recurrent swelling of the auricle; hearing loss

Earlobe is typically not involved because it has no cartilage

Noninfectious; other cartilaginous sites (trachea, nose, bronchi) can be affected

Trauma

Blunt trauma, frostbite, burns

Evidence of the trauma

Most common is laceration of the auricle

Tumors or infected cysts

Pain usually well localized to auricle or ear canal

Similar presentation to chronic otitis media or externa but nonresponsive to therapy

May be confused with chronic inflammation; if nonresponsive to therapy, timely otolaryngology referral is advised

Viral myringitis

Similar presentation to acute otitis media

Tympanic membrane red but not bulging; hemorrhagic bullae of tympanic membrane and ear canals are typical

Bullous myringitis is not pathognomonic of viral meningitis, but commonly presents in that fashion


Adapted with permission from Ely JW, Hansen MR, Clark EC. Diagnosis of ear pain. Am Fam Physician. 2008;77(5):623, 625, with additional information from reference 7.

TABLE 1.

Etiology of Primary Otalgia

EtiologyHistoryPhysical examinationAdditional information

Common causes

Barotrauma

Pain starts while scuba diving or while flying in an airplane; patient may have experienced a recent blast injury

Tympanic membrane can show middle ear hemorrhage

Prevent with use of topical nasal decongestants or autoinflation

Eustachian tube dysfunction

Symptoms of pressure dysregulation

Tympanic membrane retraction or positive tympanographic findings

Also associated with aural fullness and intermittent symptoms7

Foreign object

Commonly insects, small toys, peanuts; most common in children

Foreign object visible in ear canal

May require general anesthesia to remove

Otitis externa

Recent swimming with history of discharge

Pain with pulling on external ear; discharge may be present

More common in summer

Otitis media

Recent upper respiratory tract infection; children may pull on ears

Red, inflamed, cloudy tympanic membrane

Most common cause of ear pain

Uncommon causes

Cellulitis of auricle

Preceding insect bite, scratch, or piercing; rapid progression

Earlobe usually involved

Must treat aggressively; parenteral antibiotics may be required

Cholesteatoma

Sense of fullness

A pearly mass may be visible through the tympanic membrane; often infected with visible squamous material

May be asymptomatic early, but generally associated with hearing loss and otorrhea

Granulomatosis with polyangiitis (Wegener granulomatosis)

Arthralgia, hearing loss, myalgias, oral ulcers, otorrhea, and rhinorrhea

Often with chronic otitis media or serous otitis

Consider testing for antineutrophil cytoplasmic autoantibodies

Malignant otitis externa

Retroauricular pain; often associated with diabetes mellitus and immunocompromised state; consider in persons with no improvement in otitis externa

Granulation tissue may be present in the external auditory canal Lower cranial neuropathies (VII, X, XI, XII)

Easy to miss with subtle findings; technetium bone scan can be used to determine the extent of disease

Mastoiditis

Recent otitis media that is typically chronic but may be acute

Tender edematous mastoids

Uncommon, but prevalence is increased in children with decreased access to health care

Ramsay Hunt syndrome (herpes zoster oticus)

Pain can be present before lesions develop; may be associated with hearing loss, vertigo, or tinnitus

Vesicular rash on auricle or ear canal with possible palsy of cranial nerve VII

Can also involve cranial nerves V, IX, and X; pain can occur without eruption

Relapsing polychondritis

Recurrent swelling of the auricle; hearing loss

Earlobe is typically not involved because it has no cartilage

Noninfectious; other cartilaginous sites (trachea, nose, bronchi) can be affected

Trauma

Blunt trauma, frostbite, burns

Evidence of the trauma

Most common is laceration of the auricle

Tumors or infected cysts

Pain usually well localized to auricle or ear canal

Similar presentation to chronic otitis media or externa but nonresponsive to therapy

May be confused with chronic inflammation; if nonresponsive to therapy, timely otolaryngology referral is advised

Viral myringitis

Similar presentation to acute otitis media

Tympanic membrane red but not bulging; hemorrhagic bullae of tympanic membrane and ear canals are typical

Bullous myringitis is not pathognomonic of viral meningitis, but commonly presents in that fashion


Adapted with permission from Ely JW, Hansen MR, Clark EC. Diagnosis of ear pain. Am Fam Physician. 2008;77(5):623, 625, with additional information from reference 7.

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TABLE 2.

Etiology of Secondary Otalgia

EtiologyHistoryPhysical examinationAdditional information

Subacute etiologies

Bell palsy

Retroauricular pain that is less severe than with Ramsay Hunt syndrome

Facial weakness that involves the forehead with otherwise unremarkable examination

Pain may occur in only 50% of patients

Carotidynia

May have dysphagia or throat or neck tenderness radiating to the ear

Tender carotid artery

More common in women and often self-limited

Cervical adenopathy

Recent upper respiratory tract infection

Tender cervical lymph nodes

Consider biopsy or imaging for lymph nodes > 1.5 cm and lasting longer than two months

Cervical spine arthritis

Pain with neck movement

Reduced range of motion; tense paraspinal muscles

Referred pain from C2 and C3 cervical nerve roots

Cricoarytenoid arthritis

Pain is worse with talking, swallowing, or coughing

Inflammatory arthritis

Likely caused by rheumatoid arthritis or systemic lupus erythematosus

Dental causes (caries, abscess, pulpitis)

Dental symptoms

Caries; abscess; gingivitis; facial swelling

Caries and abscess are the most common causes

Gastroesophageal reflux

Acid reflux

Unremarkable

Pain from irritation of cranial nerves IX and X

Head and neck tumors

Increased risk: smoking, alcohol use, age ≥ 50 years, radiation exposure, weight loss

Possible painless neck mass, or no unusual findings; consider fiberoptic nasolaryngoscopy

Consider early referral; imaging should be coordinated with the otolaryngologist; pain is worse with swallowing, especially acidic or spicy foods

Idiopathic

Variable

Unremarkable

Often diagnosed as neuropathic pain, TMJ syndrome, or eustachian tube dysfunction

Myofascial pain

Cervical pain may be aggravated by chewing or neck movement

Likely to have trigger point in the neck or mastoid tip at attachment of sternocleidomastoid muscle

Consider TMJ, cervical spine, or dental disorders

Neuralgias (trigeminal, glossopharyngeal, geniculate, sphenopalatine)

Pain usually lasts seconds and is episodic, possibly with a trigger

May have trigger point, but typically the examination is unremarkable

Trigeminal is most common

Oral aphthous ulcers

Localized pain in mouth but may refer to ear

Shallow ulcers inside mouth, usually gray

Recurrent etiology not well understood

Pharyngitis or tonsillitis

Sore throat

Pharyngeal erythema; tonsillar exudate

Ear may not be directly involved

Psychogenic

History of depression or anxiety

Variable affect

May be previously diagnosed as idiopathic

Salivary gland disorders

Pain in preauricular area

Prominent parotid glands

Recent mumps outbreaks in United States; more commonly purulent parotitis associated with dehydration or stone obstruction

Sinusitis

Recent upper respiratory infection

Nasal congestion, purulent nasal discharge, anosmia

Otalgia from sinusitis is unusual

Thyroiditis (rarely causes isolated otalgia)

May have tender thyroid

Enlarged or tender thyroid

Pain is referred from the vagus nerve

TMJ syndrome

Pain/clicking with opening jaw

Tender TMJ; crepitus on motion of mandible

Leading cause of secondary otalgia in adults; risk factors include clenching and biting lips/mouth, gum chewing

Acute etiologies requiring immediate identification

Myocardial infarction

Risk factors for coronary artery disease

Unstable vital signs

If suspected, start immediate acute coronary syndrome workup

Temporal arteritis

Age ≥ 50 years; jaw claudication; diplopia

May be tender along temporal artery; may see prominent artery

Erythrocyte sedimentation rate ≥ 50 mm per hour Biopsy and immediate treatment to prevent blindness Consider early referral

Thoracic aneurysms

Older men; hypertension; risk factors for coronary artery disease

May have unstable vital signs

Computed tomography or magnetic resonance angiography

Other rare causes (subdural hematoma, lung cancer, central line placement, carotid artery aneurysm, Pott puffy tumor)

Variable

Variable

Pott puffy tumor is typically a complication of prolonged sinusitis with no treatment8


TMJ = temporomandibular joint.

Adapted with permission from Ely JW, Hansen MR, Clark EC. Diagnosis of ear pain. Am Fam Physician. 2008;77(5):624, 626, with additional information from reference 8.

TABLE 2.

Etiology of Secondary Otalgia

EtiologyHistoryPhysical examinationAdditional information

Subacute etiologies

Bell palsy

Retroauricular pain that is less severe than with Ramsay Hunt syndrome

Facial weakness that involves the forehead with otherwise unremarkable examination

Pain may occur in only 50% of patients

Carotidynia

May have dysphagia or throat or neck tenderness radiating to the ear

Tender carotid artery

More common in women and often self-limited

Cervical adenopathy

Recent upper respiratory tract infection

Tender cervical lymph nodes

Consider biopsy or imaging for lymph nodes > 1.5 cm and lasting longer than two months

Cervical spine arthritis

Pain with neck movement

Reduced range of motion; tense paraspinal muscles

Referred pain from C2 and C3 cervical nerve roots

Cricoarytenoid arthritis

Pain is worse with talking, swallowing, or coughing

Inflammatory arthritis

Likely caused by rheumatoid arthritis or systemic lupus erythematosus

Dental causes (caries, abscess, pulpitis)

Dental symptoms

Caries; abscess; gingivitis; facial swelling

Caries and abscess are the most common causes

Gastroesophageal reflux

Acid reflux

Unremarkable

Pain from irritation of cranial nerves IX and X

Head and neck tumors

Increased risk: smoking, alcohol use, age ≥ 50 years, radiation exposure, weight loss

Possible painless neck mass, or no unusual findings; consider fiberoptic nasolaryngoscopy

Consider early referral; imaging should be coordinated with the otolaryngologist; pain is worse with swallowing, especially acidic or spicy foods

Idiopathic

Variable

Unremarkable

Often diagnosed as neuropathic pain, TMJ syndrome, or eustachian tube dysfunction

Myofascial pain

Cervical pain may be aggravated by chewing or neck movement

Likely to have trigger point in the neck or mastoid tip at attachment of sternocleidomastoid muscle

Consider TMJ, cervical spine, or dental disorders

Neuralgias (trigeminal, glossopharyngeal, geniculate, sphenopalatine)

Pain usually lasts seconds and is episodic, possibly with a trigger

May have trigger point, but typically the examination is unremarkable

Trigeminal is most common

Oral aphthous ulcers

Localized pain in mouth but may refer to ear

Shallow ulcers inside mouth, usually gray

Recurrent etiology not well understood

Pharyngitis or tonsillitis

Sore throat

Pharyngeal erythema; tonsillar exudate

Ear may not be directly involved

Psychogenic

History of depression or anxiety

Variable affect

May be previously diagnosed as idiopathic

Salivary gland disorders

Pain in preauricular area

Prominent parotid glands

Recent mumps outbreaks in United States; more commonly purulent parotitis associated with dehydration or stone obstruction

Sinusitis

Recent upper respiratory infection

Nasal congestion, purulent nasal discharge, anosmia

Otalgia from sinusitis is unusual

Thyroiditis (rarely causes isolated otalgia)

May have tender thyroid

Enlarged or tender thyroid

Pain is referred from the vagus nerve

TMJ syndrome

Pain/clicking with opening jaw

Tender TMJ; crepitus on motion of mandible

Leading cause of secondary otalgia in adults; risk factors include clenching and biting lips/mouth, gum chewing

Acute etiologies requiring immediate identification

Myocardial infarction

Risk factors for coronary artery disease

Unstable vital signs

If suspected, start immediate acute coronary syndrome workup

Temporal arteritis

Age ≥ 50 years; jaw claudication; diplopia

May be tender along temporal artery; may see prominent artery

Erythrocyte sedimentation rate ≥ 50 mm per hour Biopsy and immediate treatment to prevent blindness Consider early referral

Thoracic aneurysms

Older men; hypertension; risk factors for coronary artery disease

May have unstable vital signs

Computed tomography or magnetic resonance angiography

Other rare causes (subdural hematoma, lung cancer, central line placement, carotid artery aneurysm, Pott puffy tumor)

Variable

Variable

Pott puffy tumor is typically a complication of prolonged sinusitis with no treatment8


TMJ = temporomandibular joint.

Adapted with permission from Ely JW, Hansen MR, Clark EC. Diagnosis of ear pain. Am Fam Physician. 2008;77(5):624, 626, with additional information from reference 8.

The examination also includes traction on the auricle and palpation of the tragus to differentiate disease processes affecting the external ear and ear canal (most commonly otitis externa).10 Finding vesicles in the ear canal or on the external ear may indicate herpes zoster oticus (Ramsay Hunt syndrome). If the auricular examination is unremarkable, a complete head and neck examination should also be performed, paying special attention to the TMJ and the nasal and oral cavities. TMJ syndrome commonly presents with discomfort or crepitus on palpation of the TMJ. A variety of dental causes of otalgia can be identified by evaluating the oral cavity with palpation and percussion of the gum line and teeth, specifically the molars.11 Evaluation of the oropharynx may also result in findings diagnostic of pharyngitis and other oropharyngeal disorders that can radiate pain to the ear.

Patients with abnormal vital signs who present initially with otalgia may have a serious infection, such as meningitis or sepsis, or serious traumatic injury, such as epidural hematoma. Patients with ear pain and abnormal mental status must be evaluated for traumatic injury, epidural infection, and osteomyelitis.8

Evaluation

The diagnosis of primary otalgia rarely requires more than a history and physical examination (Figure 2).5 Likewise, most cases of secondary otalgia can be diagnosed with a history and physical examination. Concerning historical features include progressive or unrelenting symptoms, unintentional weight loss, exertional pain, behavioral risk factors (e.g., tobacco exposure, heavy alcohol consumption), medical history (e.g., immunocompromised state, coronary artery disease, cancer, diabetes mellitus), and new-onset symptoms in patients 50 years or older. When the physical examination is unremarkable (especially if there are concerning historical features), nasolaryngoscopy, tympanometry, audiometry, and laboratory evaluation with a complete blood count and erythrocyte sedimentation rate can be helpful. Magnetic resonance imaging, computed tomography, and, if there is a history of cancer, positron emission tomography may be performed to provide further information.2,5,1214 Advanced imaging for evaluation of otalgia may be most efficiently ordered in consultation with an otolaryngologist.

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FIGURE 2.

Algorithm for the evaluation of ear pain.

NSAID = nonsteroidal anti-inflammatory drug; TMJ = temporomandibular joint.

Adapted with permission from Ely JW, Hansen MR, Clark EC. Diagnosis of ear pain. Am Fam Physician. 2008;77(5):622.


FIGURE 2.

Algorithm for the evaluation of ear pain.

NSAID = nonsteroidal anti-inflammatory drug; TMJ = temporomandibular joint.

Adapted with permission from Ely JW, Hansen MR, Clark EC. Diagnosis of ear pain. Am Fam Physician. 2008;77(5):622.

Primary Otalgia

Primary otalgia can be further delineated into pain originating from the external ear, ear canal, or middle ear (Table 1).5,7 External ear pain can be due to several factors, including trauma, sunburn, acute folliculitis, contact dermatitis, shingles, and other skin conditions. When trauma is suspected, the temporal and parietal regions of the skull should be assessed and appropriate imaging ordered. Disorders of the external auditory canal that may cause pain include cerumen impaction, foreign bodies, and, most commonly, infection of the canal.

Otitis externa (commonly known as swimmer's ear) is caused by bacterial infections (90%) and fungal infections (10%).5,15 Ear pain originating in the middle ear is typically due to acute otitis media, but can also be from bullous myringitis, barotrauma, and eustachian tube dysfunction.16 Otitis media is most commonly caused by Streptococcus pneumoniae, Moraxella catarrhalis, or Haemophilus influenzae.9 Eustachian tube dysfunction is also a common cause of primary otalgia, affecting an estimated 3% of patients presenting with otalgia.4 A consensus definition of eustachian tube dysfunction is signs and symptoms of pressure dysregulation in the middle ear diagnosed with otoscopic evidence of tympanic membrane retraction and/or tympanogram indicating negative middle ear pressure.17 Bullous myringitis is uncommon, but occurs when serous or hemorrhagic blisters form in the ear canal or on the lateral tympanic membrane (usually caused by a bacterial or viral infection); symptoms generally include sudden onset of severe ear pain and hearing loss.16 Pain often decreases after bullae rupture and drain.

Uncommon causes of primary otalgia include infectious, neoplastic, and inflammatory etiologies. Mastoiditis, an infection in the air cells of the skull behind the ear, is a rare complication from acute otitis media. This diagnosis is based on physical examination findings of tenderness, erythema, edema, and warmth in the mastoid region.18 Malignant otitis externa is a rare condition found in patients with diabetes or who are immunocompromised. It is characterized by severe unrelenting pain and a subtle finding of inferior external auditory canal granulation tissue at the bony cartilaginous junction. Pseudomonas infection involving the skull base (osteitis) can result in lower cranial neuropathies.19 Herpes zoster oticus is caused by reactivation of latent herpes zoster infection from the geniculate ganglion (cranial nerve VII or facial nerve), but also can involve cranial nerves V, IX, and X. Symptoms include ear pain and facial paralysis while the patient has vesicles in the external auditory canal.5

Cholesteatomas may produce a sense of fullness rather than severe pain but may also be asymptomatic. An epidermal cyst develops in the superior, usually posterior, aspect of the tympanic membranes. The cyst can cause conductive hearing loss secondary to local destruction of middle ear structures and may present with otorrhea consisting of desquamating epithelium.5 Relapsing polychondritis is a rare systemic disease involving the cartilage of many organs, but most commonly the ears. It is characterized by a relapsing, bilateral, erythematous or violaceous appearance on the external ear, sparing the ear lobes.2

Secondary Otalgia

The complex embryologic development of the ear results in neural connections to several cranial and cervical nerves. These nerves provide sensory innervation to regions of the head, neck, chest, and abdomen, which can result in referred pain to the ear 14 (Figure 1 and Table 2 5,8). Referred pain from the trigeminal nerve (cranial nerve V) is the most common source of secondary otalgia stemming from TMJ syndrome, dental infections, trigeminal neuralgia, sinusitis, and mandibular osteomyelitis or tumor.4 Herpes zoster can affect cranial nerve VII to a lesser degree than in Ramsay Hunt syndrome, which can also cause ear pain associated with Bell palsy and an unremarkable ear examination.4 Cranial nerve IX can refer pain caused by tonsillitis, pharyngitis, pharyngeal tumor, or glossopharyngeal neuromas.4 The vagus nerve affects many systems as inferior as the colon and can be activated by any vagal stimulation. Otalgia has been reported as the presenting symptom of myocardial ischemia from irritation of the vagus nerve.20

Secondary otalgia can be caused by irritation of C2 and C3 cervical nerve roots, especially in patients with cervical spine degeneration. Tumor, infection, or an inflammatory process within the sensory distribution of any of these nerves may cause referred pain to the ear.4 An example of this is temporal arteritis, which presents with temporal pain in only 40% of patients. Temporal arteritis should be considered in patients 50 years or older who have normal ear examination findings and any of the following symptoms: headache, malaise, weight loss, fever, or anorexia. Permanent blindness may result if systemic steroids are not initiated promptly. In suspected cases, an elevated erythrocyte sedimentation rate (50 mm per hour or greater) warrants immediate treatment with systemic steroids and surgical consultation to confirm the diagnosis.14

Risk Factors for a Serious Diagnosis in Patients with Otalgia

There are some characteristics that make a serious diagnosis more likely in patients with otalgia. Treatment is most effective when there is minimal delay after diagnosis. Patients who are 50 years or older, have coronary artery disease, have diabetes, or are immunocompromised are at higher risk. In addition, patients who smoke, drink alcohol, or lose weight unintentionally should undergo more scrutiny. Consumption of 50 g or more of alcohol per day (approximately 3.5 or more drinks per day) increases the risk of head, neck, and esophageal cancers by two to three times compared with nondrinkers; smoking and drinking alcohol increase the risk compared with alcohol use alone.21 In addition, unilateral hearing loss warrants further investigation if an obvious cause (e.g., cerumen impaction, foreign body) is not apparent.5

This article updates a previous article on this topic by Ely, et al.4

Data Sources: A PubMed search for evaluation and diagnosis of ear pain or otogenic otalgia or primary otalgia or secondary otalgia or otalgia was performed. The search was further limited by English only, human studies, and over the past five years. In addition to this search, we used articles from the reference list of the 2008 AFP article on ear pain,5 as well as reference lists of articles selected from our PubMed search. Search dates: July 27, 2016, and April 10, 2017.

The views expressed in this article are those of the authors and do not reflect the policy or position of the U.S. Army Medical Department, Department of the Army, Department of Defense, or the U.S. government.

The Authors

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JOHN SCOTT EARWOOD, MD, is assistant program director of the Family Medicine Residency Program at Dwight D. Eisenhower Army Medical Center, Fort Gordon, Ga., and assistant professor of family medicine at the Uniformed Services University of the Health Sciences F. Edward Hébert School of Medicine, Bethesda, Md....

TYLER SHERROD ROGERS, MD, is a faculty member in the Family Medicine Residency Program at Dwight D. Eisenhower Army Medical Center. At the time the article was submitted, Dr. Rogers was chief resident of the Family Medicine Residency Program at Dwight D. Eisenhower Army Medical Center.

NICHOLAS ALAN RATHJEN, DO, is chief resident of the Family Medicine Residency Program at Dwight D. Eisenhower Army Medical Center.

Address correspondence to John Scott Earwood, MD, Dwight D. Eisenhower Army Medical Center, 300 Hospital Dr., Fort Gordon, GA 30905 (e-mail: john.s.earwood.civ@mail.mil). Reprints are not available from the authors.

Author disclosure: No relevant financial affiliations.

References

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1. Majumdar S, Wu K, Bateman ND, Ray J. Diagnosis and management of otalgia in children. Arch Dis Child Educ Pract Ed. 2009;94(2):33–36....

2. Neilan RE, Roland PS. Otalgia. Med Clin North Am. 2010;94(5):961–971.

3. Kozin ED, Sethi RK, Remenschneider AK, et al. Epidemiology of otologic diagnoses in United States emergency departments. Laryngoscope. 2015;125(8):1926–1933.

4. Kim SH, Kim TH, Byun JY, Park MS, Yeo SG. Clinical differences in types of otalgia. J Audiol Otol. 2015;19(1):34–38.

5. Ely JW, Hansen MR, Clark EC. Diagnosis of ear pain. Am Fam Physician. 2008;77(5):621–628.

6. Poelmans J, Tack J, Feenstra L. Prospective study on the incidence of chronic ear complaints related to gastroesophageal reflux and on the outcome of antireflux therapy. Ann Otol Rhinol Laryngol. 2002;111(10):933–938.

7. Park MS, Lee HY, Kang HM, Ryu EW, Lee SK, Yeo SG. Clinical manifestations of aural fullness. Yonsei Med J. 2012;53(5):985–991.

8. Schwartz RH, Zingariello C, Levorson R, Myseros JS, Kamat R, Fetter TW. Pott puffy tumor in an unsual location. OJPed. 2013;3(2):147–150.

9. Harmes KM, Blackwood RA, Burrows HL, Cooke JM, Harrison RV, Passamani PP. Otitis media: diagnosis and treatment [published correction appears in Am Fam Physician. 2014;89(5):318]. Am Fam Physician. 2013;88(7):435–440.

10. Sanyaolu LN, Farmer SE. Acute otalgia and otorrhoea in primary care. BMJ. 2016;352:i844.

11. Kim DS, Cheang P, Dover S, Drake-Lee AB. Dental otalgia. J Laryngol Otol. 2007;121(12):1129–1134.

12. Chen RC, Khorsandi AS, Shatzkes DR, Holliday RA. The radiology of referred otalgia. AJNR Am J Neuroradiol. 2009;30(10):1817–1823.

13. Ismail H, Hellier WP, Batty V. Use of magnetic resonance imaging as the primary imaging modality in the diagnosis and follow-up of malignant external otitis. J Laryngol Otol. 2004;118(7):576–579.

14. Smetana GW, Shmerling RH. Does this patient have temporal arteritis? JAMA. 2002;287(1):92–101.

15. Schulze SL, Kerschner J, Beste D. Pediatric external auditory canal foreign bodies: a review of 698 cases. Otolaryngol Head Neck Surg. 2002;127(1):73–78.

16. McCormick DP, Saeed KA, Pittman C, et al. Bullous myringitis: a case-control study. Pediatrics. 2003;112(4):982–986.

17. Schilder AG, Bhutta MF, Butler CC, et al. Eustachian tube dysfunction: consensus statement on definition, types, clinical presentation and diagnosis. Clin Otolaryngol. 2015;40(5):407–411.

18. Bahadori RS, Schwartz RH, Ziai M. Acute mastoiditis in children: an increase in frequency in Northern Virginia. Pediatr Infect Dis J. 2000;19(3):212–215.

19. Karaman E, Yilmaz M, Ibrahimov M, Haciyev Y, Enver O. Malignant otitis externa. J Craniofac Surg. 2012;23(6):1748–1751.

20. Dundar R, Kulduk E, Kemal Soy F, Sengul E, Ertas F. Myocardial infarction as a rare cause of otalgia. Case Rep Otolaryngol. 2014;2014:106938.

21. Baan R, Straif K, Grosse Y, et al.; WHO International Agency for Research on Cancer Monograph Working Group. Carcinogenicity of alcoholic beverages. Lancet Oncol. 2007;8(4):292–293.

 

 

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