POEMs

Patient-Oriented Evidence That Matters

Routine Oxygen Supplementation After Acute Stroke Does Not Improve Functional Outcomes

 

Am Fam Physician. 2018 Apr 15;97(8):533.

Clinical Question

Does routine low-dose oxygen therapy following an acute stroke improve functional outcomes?

Bottom Line

For nonhypoxic patients with acute stroke, routine oxygen therapy for 72 hours, either continuously or at night only, does not improve functional outcomes at 90 days. Long-term outcomes were not assessed in this study, and the question remains whether 90 days is an adequate length of time to see most of the meaningful recovery from stroke. (Level of Evidence = 1b)

Synopsis

Adults with a clinical diagnosis of acute stroke and no indication for or contraindication to oxygen were randomized to receive continuous oxygen therapy for 72 hours, nocturnal oxygen therapy for three nights, or no oxygen supplementation. Oxygen was delivered at 3 L per minute if baseline saturation was 93% or less and 2 L per minute if baseline saturation was higher than 93%. The primary outcome was the 90-day modified Rankin Scale score for disability (range: 0 to 6, where 0 = no symptoms, 3 = moderate disability, and 6 = death). A total of 8,003 patients were randomized into one of the three groups using concealed allocation. After excluding patients who either withdrew before the 90-day assessment, were lost to follow-up, or had missing data for the primary outcome, 7,719 patients remained in the modified intention-to-treat analysis. Overall, 92% of the study patients were independent in basic activities of daily living before the symptoms of stroke, and baseline characteristics were similar in the three groups.

Adherence to the treatment was 81% in the continuous oxygen group and 83% in the nocturnal oxygen group. The main reason for early discontinuation of oxygen was discharge from the hospital. In the primary analysis, oxygen supplementation did not improve functional outcomes at 90 days when comparing the two oxygen groups with the control group or when comparing the continuous oxygen group with the nocturnal oxygen group. Additionally, there were no differences in 90-day

POEMs (patient-oriented evidence that matters) are provided by EssentialEvidence Plus, a point-of-care clinical decision support system published by Wiley-Blackwell. For more information, please see http://www.essentialevidenceplus.com. Copyright Wiley-Blackwell. Used with permission.

For definitions of levels of evidence used in POEMs, see http://www.essentialevidenceplus.com/product/ebm_loe.cfm?show=oxford.

To subscribe to a free podcast of these and other POEMs that appear in AFP, search in iTunes for “POEM of the Week” or go to http://goo.gl/3niWXb.

This series is coordinated by Sumi Sexton, MD, Editor-in-Chief.

A collection of POEMs published in AFP is available at http://www.aafp.org/afp/poems.

 

 

Want to use this article elsewhere? Get Permissions

CME Quiz

More in AFP


Editor's Collections


Related Content


More in Pubmed

MOST RECENT ISSUE


Dec 15, 2018

Access the latest issue of American Family Physician

Read the Issue


Email Alerts

Don't miss a single issue. Sign up for the free AFP email table of contents.

Sign Up Now

Navigate this Article