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Pregabalin (Lyrica) for Acute Fibromyalgia Pain

 

Am Fam Physician. 2018 May 1;97(9):online.

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PREGABALIN (LYRICA) FOR ACUTE PAIN IN FIBROMYALGIA

BenefitsHarms

1 in 11 experienced moderate to substantial symptom benefit after taking the medication

1 in 11 stopped taking the medication because of adverse effects

PREGABALIN (LYRICA) FOR ACUTE PAIN IN FIBROMYALGIA

BenefitsHarms

1 in 11 experienced moderate to substantial symptom benefit after taking the medication

1 in 11 stopped taking the medication because of adverse effects

Details for This Review

Study Population: Adults with fibromyalgia

Efficacy End Points: At least a moderate to substantial symptom benefit

Harm End Points: Withdrawal from trials because of adverse effects

Narrative: Fibromyalgia is a potentially debilitating disease characterized by widespread pain, fatigue, and sleep problems. In its most severe form, fibromyalgia can be incapacitating. High-quality studies analyzed in a Cochrane review consistently showed pregabalin (Lyrica) to have an effect on reducing pain in approximately 9% of patients with fibromyalgia, with a number needed to treat of 11.1 The studies showed a moderate to substantial symptom benefit in 331 (36%) of 932 patients receiving pregabalin compared with 251 (27%) of 937 patients receiving a placebo. Symptom improvement is an important end point that matters to patients and can have a positive effect on quality of life.1

The studies also showed a number of adverse effects with pregabalin use, most commonly dizziness and somnolence. Adverse effects occurred in 17% of patients in the treatment group compared with 9% of patients in the placebo group. Patients had to discontinue taking the medication because of these adverse effects at about the same rate at which their symptoms improved, giving the medication a number needed to harm of 11. Given the benefit shown in multiple high-quality studies, we have labeled this treatment as green. However, patients should be made aware that

Author disclosure: No relevant financial affiliations.

References

1. Derry S, Cording M, Wiffen PJ, Law S, Phillips T, Moore RA. Pregabalin for pain in fibromyalgia in adults. Cochrane Database Syst Rev. 2016;(9):CD011790.

2. Lyrica (pregabalin) [prescribing information]. Veja Baja, PR: Pfizer Pharmaceuticals. June 2012. https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2016/021446orig1s030,022488orig1s010ltr.pdf. Accessed April 5, 2018.

 

 

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