Exercise-Associated Hyponatremia: Updated Guidelines from the Wilderness Medical Society
Am Fam Physician. 2021 Feb 15;103(4):252-253.
Author disclosure: No relevant financial affiliations.
Key Points for Practice
• EAH risk can be reduced by limiting drinking only to respond to thirst with prolonged exertion.
• Because EAH and heat illness symptoms overlap, rectal temperature measurement is critical when assessing altered mental status associated with prolonged exertion.
• Severe EAH is best treated with hypertonic saline boluses. Aggressive cooling can be added if heat illness is also suspected.
• Mild EAH is treated with fluid restriction and oral hypertonic solutions, or salty foods can be added.
From the AFP Editors
Exercise-associated hyponatremia (EAH) occurs when exertion results in sodium concentration less than 135 mEq per L (135 mmol per L), and symptoms can present up to 24 hours after physical activity. When asymptomatic ultramarathon participants are screened, up to one-half demonstrate hyponatremia. The usual cause of EAH is overhydration with hypotonic fluids such as water or sports drinks.
EAH must be differentiated from heat illness to avoid inappropriate treatment and adverse outcomes. Mild EAH symptoms of weakness, malaise, fatigue, irritability, headache, bloating, dizziness, and nausea and vomiting can also occur with heat exhaustion. Severe EAH presents with mental status changes similar to exertional heat stroke. High ambient temperatures increase the risk of EAH as well as heat illness. Injury logs from a national park showed that one in five nonfatal incidents initially characterized as heat-related were due to EAH. The Wilderness Medical Society has published updated guidelines for prevention, diagnosis, and treatment of EAH.
EAH prevention centers on avoiding overhydration. No specific fluid volume intake recommendations have been shown to prevent hyponatremia, so the best recommendation is to limit drinking to respond to thirst. Limiting fluid availability during distance events reduces EAH rates.
Although fluids are lost through sweat during exercise, determining fluid replacement based on weight loss during prolonged exercise does not prevent EAH. Changes in antidiuretic hormone (ADH) levels can predispose to EAH, and ADH levels increase with pain, stress, exercise, nausea, and hypoglycemia. Common medications such as nonsteroidal anti-inflammatory drugs and selective serotonin reuptake inhibitors can also increase ADH.
Because EAH is caused by overconsumption of hypotonic oral fluids and inappropriately elevated ADH levels, affected people most often have elevated or normal total body water. Hypovolemic EAH is uncommon and associated with chronic diuretic use and older age.
The increased desire for high-sodium foods after prolonged sweating suggests that salt can be replaced orally. Sodium-rich foods and fluids should be available during lengthy exertion in high temperatures, although they will not prevent EAH when overdrinking occurs.
Because EAH symptoms overlap those of heat illness, rapid assessment of rectal temperature is essential when altered mental status is associated with prolonged exertion. Sodium point-of-care testing can be helpful if concomitant EAH is suspected, but availability is limited by high cost and requirement to keep testing kits within specified temperature ranges. If available, point-of-care testing for sodium and glucose is recommended for symptomatic athletes.
Diagnosis of EAH will most often depend on a history of aggressive hydration and temperatures that are normal or minimally elevated. Overlapping symptoms make clinical assessment challenging (Table 1). Without mental status changes, orthostatic symptoms and thirst can suggest heat illness, whereas bloating and lack of thirst can suggest EAH.
Coverage of guidelines from other organizations does not imply endorsement by AFP or the AAFP.
This series is coordinated by Michael J. Arnold, MD, contributing editor.
A collection of Practice Guidelines published in AFP is available at https://www.aafp.org/afp/practguide.
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