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Am Fam Physician. 2008;77(6):828-830

This is part I of a two-part piece on the diagnosis of appendicitis. Part II, “Laboratory and Imaging Tests,” will appear in the April 15, 2008, issue of AFP.

Clinical Question

What are the most useful elements of the patient history and physical examination in the diagnosis of appendicitis?

Evidence Summary

Appendicitis is a relatively uncommon, but potentially serious, cause of abdominal pain in the primary care setting. An accurate diagnosis is important to prevent unnecessary surgery and avoid complications.

The probability of appendicitis depends on patient age, setting, and symptoms. A retrospective study, including three family practice centers, identified 556 adults with abdominal pain, of whom six (1.1 percent) were diagnosed with appendicitis.1 Studies of children with abdominal pain, largely in the emergency department setting, found that 10 to 25 percent of patients had appendicitis.2 In studies of patients with abdominal pain who underwent computed tomography and ultrasonography, 31 percent of children and 40 percent of adults had appendicitis.3 The percentage of patients with appendicitis ranges from 60 to 90 percent in patients who undergo surgery. Perforation rates range from 4 to 28 percent.4

Individual signs and symptoms are of some value in the evaluation of patients with suspected appendicitis. In many patients, signs and symptoms are useful at ruling in appendicitis when findings are positive or abnormal, but the absence of signs and symptoms does not necessarily reduce the risk of appendicitis (Table 12,5). In adults, right lower quadrant pain and migration of pain from the umbilicus area to the right lower quadrant are the symptoms that best predict appendicitis, whereas the absence of pain before vomiting greatly reduces the likelihood of appendicitis.5 The accuracy of history and physical examination findings is somewhat different in children. Vomiting, rectal tenderness, rebound tenderness, and fever are more helpful (greater positive likelihood ratio) in children than in adults, whereas right lower quadrant tenderness is somewhat less helpful.2 The usefulness of the finding of pain before vomiting has not been evaluated in children.

Clinical findingLikelihood ratio*
AdultsChildren
Helpful for ruling in appendicitis
Right lower quadrant pain8.4
Migration (periumbilical to right lower quadrant)3.61.9 to 3.1
Initial clinical impression of the surgeon3.53.0 to 9.0†
Psoas sign3.22.5
Fever3.23.4
Pain before vomiting2.7
Rebound tenderness2.03.0
Rectal tenderness2.3
Vomiting2.2
Helpful for ruling out appendicitis
Absence of pain before vomiting0.02
Absence of right lower quadrant pain0.18
Absence of vomiting0.33
Absence of fever0.420.32
Absence of rebound tenderness0.28

The Alvarado score (also known as the MANTRELS [Migration of pain, Anorexia, Nausea/vomiting, Tenderness in the right lower quadrant, Rebound pain, Elevation of temperature, Leukocytosis, Shift to the left] score; Table 22,6) has been prospectively validated in several populations of children610 and adults.11 Variations include the modified Alvarado score, which excludes the left shift of the white blood cell (WBC) count,12 and the Pediatric Appendicitis Score, which substitutes right lower quadrant pain with cough, hopping, or percussion for rebound tenderness.7 However, these modifications have not been shown to perform better than the original Alvarado score.

Clinical FindingPoints
Migration of pain to the right lower quadrant1
Anorexia1
Nausea/vomiting1
Tenderness in the right lower quadrant2
Rebound pain1
Elevated temperature (≥ 99.1º F [37.3º C])1
Leukocytosis (≥ 10,000 WBCs per mm3 [10 × 109 per L])2
Shift of WBC count to the left (> 75 percent neutrophils)1
Total:_______

Another score, which includes nine clinical variables and does not require a WBC count, accurately predicted the likelihood of appendicitis in the initial validation study of 109 children.13 However, this and several other proposed diagnostic scores have not been prospectively validated in large, clinically relevant populations.

The Ohmann score (Table 3) includes seven clinical variables and a WBC count.14 The score was developed in a group of 870 patients at German and Austrian hospitals and was validated four months later in a second group of patients at the same hospitals. In the prospective validation, the Ohmann score successfully identified patients at low, moderate, and high risk of appendicitis.14

Clinical FindingPoints
Tenderness in the right lower quadrant4.5
Rebound tenderness2.5
No difficulty with micturition2.0
Steady pain2.0
Leukocytosis (≥ 10,000 white blood cells per mm3 [10 × 109 per L])1.5
Age less than 50 years1.5
Migration of pain to the right lower quadrant1.0
Abdominal rigidity1.0
Total:_______









The Alvarado and Ohmann scores alone are not accurate enough to diagnose or exclude appendicitis. However, they provide a useful starting point by identifying children and adults at low, moderate, and high risk of appendicitis. Most patients at low risk can be observed without further diagnostic study; patients at moderate risk may benefit from further diagnostic testing, including imaging studies; and patients at high risk should receive urgent surgical evaluation. Part II of this series addresses diagnostic testing in the context of the Alvarado and Ohmann scores.

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