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Am Fam Physician. 2018;97(11):750-752

Related letter: Pulmonary Embolism Clinical Decision Tools Can Be Helpful During In-Flight Medical Emergencies

Author disclosure: No relevant financial affiliations.

Clinical Question

What is the best approach to evaluate patients with suspected pulmonary embolism (PE) in the outpatient primary care setting?

Evidence Summary

Acute PE accounts for one out of 400 to 1,500 adult presentations to the emergency department,1 with a 30-day mortality rate of 5.4%.2 Chronic thromboembolic pulmonary hypertension further adds to morbidity in 4.8% of patients who survive PE.3 However, PE has a highly variable presentation.

Many clinical decision rules exist to estimate the patient's risk level based on certain clinical characteristics and subsequently guide the evaluation of suspected PE. These include the Wells score, Geneva score, Pisa model, and Pulmonary Embolism Rule-out Criteria (PERC). Each of the rules has advantages and disadvantages (eTable A). A primary care protocol that uses three of these rules to rule out PE is presented in Table 1.4

Clinical decision ruleMultiple validated versions?Number of characteristicsCharacteristics that are not history or physical examination findingsAttributes requiring subjective judgments?Validated in outpatient emergency department?Validated in primary care?Comments
Geneva scoreYes8NoneNoYesYesVersions: original, revised, simplified revised
Pisa modelYes11Chest radiograph or electrocardiogramNoYesNo
Pulmonary Embolism Rule-out CriteriaYes8NoneNoYesNoCombine with other clinical decision rules per American College of Physicians
Wells scoreYes7NoneYesYesYes (Netherlands)Versions: original, modified, simplified
Wells + ultrasonographyNo7Point-of-care ultrasonographyNoYesNo
Wells scoreGeneva scorePERC

Clinical characteristicsPointsClinical characteristicsPointsClinical characteristics
Previous PE or DVT1Previous PE or DVT1No history of venous thromboembolism
Surgery or immobilization within four weeks of presentation1Surgery or fracture of the lower limbs within one month of presentation1No surgery or trauma within four weeks
Hemoptysis1Hemoptysis1Initial oxygen saturation > 94% on room air
Clinical signs of DVT1Pain on lower limb deep venous palpation and unilateral edema1No hemoptysis
Alternative diagnosis less likely than PE1Unilateral lower limb pain1No unilateral leg swelling
Active cancer1Active cancer1No estrogen use
Heart rate > 100 beats per minute1Heart rateInitial heart rate < 100 beats per minute
Total:______75 to 94 beats per minute1
≥ 95 beats per minute2Age < 50 years
Age > 65 years1
Total:______
Interpretation: Patients with fewer than 2 points on the Wells score or 2 points or fewer on the Geneva score have a low risk of PE. Absence of PE should be confirmed using the PERC or d-dimer testing. If either is negative, PE is ruled out.Interpretation: PE is ruled out in patients with all of the above characteristics.

The Wells score consists of seven characteristics based on the history and physical examination, forgoing the need for additional testing.5 However, the Wells score incorporates a subjective judgment: an estimate of the probability of PE and whether it is more or less likely than an alternative diagnosis. Each characteristic is assigned a point value, and the cumulative score places patients into risk categories that guide further testing.6 There are several versions of the Wells score. The original, modified, and simplified versions are most commonly used, and each assigns different point values for the characteristics and have two or three risk categories.5,7 A recent study examining the use of point-of-care ultrasonography of the lung and lower extremities in 446 emergency department patients found that it improved the accuracy of the Wells score compared with the Wells score alone.8

The Geneva score consists of eight objective characteristics, eliminating the physician's subjective judgment. Like the Wells score, each characteristic is assigned a point value, and the cumulative score stratifies patients into different risk categories. There are several versions of the Geneva score (the original, revised, and simplified revised), adjusting point values and risk categories to alter performance.

The PERC consists of eight characteristics. In a study of 61,322 patients in an urban emergency department, those with none of the characteristics had a less than 1% likelihood of PE.9 The Pisa model consists of 11 characteristics but requires an electrocardiogram or a chest radiograph, depending on the version.10,11

All of these clinical decision rules were originally validated in an emergency department and/or tertiary care referral center. Differences in the prevalence of PE may limit their use (or alter their interpretation) in a primary care setting. Only the Wells and Geneva scores have been studied specifically in primary care, making them the preferred clinical decision rules in this setting.

With multiple versions of a clinical decision rule, it is important to correlate the point values with the correct version of risk strata to properly assess a patient's likelihood of PE.

A study comparing different versions of the Geneva and Wells scores in a prospective cohort of inpatients and outpatients found that all versions were similar in performance.12 A meta-analysis of 12 studies including 3,613 inpatients and outpatients from emergency departments concluded that the original Wells score was more accurate and effective than the revised Geneva score.13 A Dutch study of 662 patients is the only validation study in the primary care setting. The study found that although the Wells and Geneva scores had similar discrimination as measured by the area under the receiver operating characteristic curve, the Wells score classified fewer patients with PE into the low-risk category (1.98% difference between the simplified Wells score and the simplified revised Geneva score).14 When used as a clinical decision rule to assess pretest probability, this characteristic is most important.

The American College of Physicians Best Practice Advice recommends a clinical decision rule be used first to estimate pretest probability for acute PE. If the pretest probability is low and the PERC rule score is 0, then it is reasonable to forgo other testing, including checking d-dimer.4

Applying the Evidence

A 49-year-old man presents to your office with increasing shortness of breath that began two days ago. He has a productive cough but no hemoptysis. He does not have a history of deep venous thrombosis or PE episodes, recent surgeries, fractures or prolonged periods of immobilization, or cancer. He has a 30-pack-year smoking history but has never had pulmonary function testing. He has no sick contacts and does not have fever, chills, or other signs or symptoms suggesting pneumonia. On examination, he has no lower extremity swelling or pain, Homans sign is negative, and his pulse is 92 beats per minute. His pulse oxygen level is 97% on room air.

He receives 0 points on the simplified Wells score; therefore, PE is a less likely diagnosis than chronic obstructive pulmonary disease. He receives 1 point on the simplified revised Geneva score. Based on these scores, the patient has a low pretest probability of PE. The PERC rules out PE. It would be reasonable to forgo any further testing for PE.4

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