John R. McConaghy, Rachael McGuirk
Early recognition and treatment of amblyopia in children are important to prevent vision loss. All children three to five years of age should be screened at least once to detect amblyopia or its risk factors. Routine, age-appropriate red reflex testing, examination for signs...
David Y. Gaitonde, Faith C. Moore, Mackenzie K. Morgan
The hallmark of influenza infection is abrupt onset of fever, cough, chills or sweats, myalgias, and malaise. For most patients in the outpatient setting, the diagnosis is made clinically, and laboratory confirmation is not necessary. Laboratory testing may be useful in...
Andrew Smith, Katrina Baumgartner, Christopher Bositis
Cirrhosis is the 12th leading cause of death in the United States, but only one in three people know they have it. New research shows that early cirrhosis may be reversible. Most patients remain asymptomatic until the onset of decompensation; evaluation should begin...
John Mandrola, Andrew Foy
Although coronary artery calcium testing may slightly improve future risk prediction, this theoretical benefit is outweighed by its potential harms.
Key clinical questions and their evidence-based answers directly from the journal's content, written by and for family physicians.
Andy Lazris, Alan R. Roth
A collaboration between AFP and the Lown Institute promotes a vision of delivering heath care that is based on the evidence, balanced in its approach, and focused on the patient.
Howard Tracer, Aliye Sanou
A 71-year-old woman comes to your office for a regularly scheduled visit. She has type 2 diabetes mellitus and a 50-pack-year smoking history, and had non-ulcer dyspepsia two years ago. Her body mass index is 32 kg per m2, and her blood pressure is normal.
John E. Snellings, Kyle J. Adams
A man presented with a vesicular rash on his ankle in a serpentine-like pattern.
Deborah R. Erlich
Single-dose baloxavir should be limited to ill patients who cannot tolerate or comply with a course of oseltamivir. For otherwise healthy adults with confirmed influenza or influenza-like illness, the high cost of baloxavir may not justify the one-day reduction in symptoms of...
What is the best approach to the evaluation of nonpregnant adults with suspected first lower extremity deep venous thrombosis (DVT) in the outpatient primary care setting?
The American College of Obstetricians and Gynecologists (ACOG) has released an updated practice bulletin to outline diagnosis, effects on pregnancy outcomes, and approaches for management based on new evidence.
The USPSTF recommends against screening for pancreatic cancer in asymptomatic adults.
Henry C. Barry
In this study, platelet-rich plasma injections were no better than saline injections in improving pain or activity in patients with patellar tendinopathy. It did not matter whether the plasma was leukocyte rich or leukocyte poor.
Allen F. Shaughnessy
The available evidence that treatment-resistant depression (depression that is unresponsive to two different treatments of adequate dose and length) responds well to augmentation treatment (i.e., adding psychotherapy, lithium, or aripiprazole [Abilify] to current treatment)...
Mark H. Ebell
Baloxavir has similar efficacy to oseltamivir (Tamiflu) (33-hour reduction in duration of symptoms compared with placebo) and, like oseltamivir, is most effective when given within 24 hours of the onset of symptoms.
David C. Slawson
This study found that one month of dual antiplatelet therapy (aspirin plus clopidogrel or prasugrel [Effient]) followed by clopidogrel monotherapy for up to five years is both noninferior and superior to 12 months of dual antiplatelet therapy followed by aspirin for up to...
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