
Am Fam Physician. 2021;104(6):580-588
Author disclosure: No relevant financial affiliations.
Nutrition support therapy is the delivery of formulated enteral or parenteral nutrients to restore nutritional status. Family physicians can provide nutrition support therapy to patients at risk of malnutrition when it would improve quality of life. The evidence for when to use nutrition support therapy is inconsistent and based mostly on low-quality studies. Family physicians should work with registered dietitian nutritionists to complete a comprehensive nutritional assessment for patients with acute or chronic conditions that put them at risk of malnutrition. When nutrition support therapy is required, enteral nutrition is preferred for a patient with a functioning gastrointestinal tract, even in patients who are critically ill. Parenteral nutrition has an increased risk of complications and should be administered only when enteral nutrition is contraindicated. Family physicians can use the Mifflin-St Jeor equation to calculate the resting metabolic rate, and they should consult with a registered dietitian nutritionist to determine total energy needs and select a nutritional formula. Patients receiving nutrition support therapy should be monitored for complications, including refeeding syndrome. Nutrition support therapy does not improve quality of life in patients with dementia. Clinicians should engage in shared decision-making with patients and caregivers about nutrition support in palliative and end-of-life care.
Nutrition support therapy is the delivery of formulated enteral or parenteral nutrients to maintain or restore nutritional status. Enteral nutrition (EN) support is the provision of nutrition using an enteral device inserted into the gastrointestinal (GI) tract. Parenteral nutrition (PN) support is the provision of nutrition intravenously. The evidence for when to use nutrition support therapy is inconsistent and based mostly on low-quality studies. Family physicians can provide nutrition support therapy to patients at risk of malnutrition when it would improve quality of life. This article focuses on caring for adults who need nutrition support therapy, which generally occurs in the hospital setting.
Clinical recommendation | Evidence rating | Comments |
---|---|---|
Physicians should work with a registered dietitian nutritionist who uses the Nutrition Care Process framework to assess the need for nutrition support therapy in patients at risk of malnutrition.6 | C | Guidelines recommended using a standard process for assessing nutritional risk. |
Consider initiating EN feedings within 24 hours of gastrointestinal surgery.13 | B | A systematic review of low-quality studies showed a decreased length of hospital stay, but no effect on other outcomes. |
In nonsevere acute pancreatitis, initiate early oral feeding. If nutrition support therapy is needed, use EN over total PN.14,15 | A | A systematic review showed no harms of early feeding and a reduced length of stay; a systematic review showed that in patients needing nutrition support, EN significantly decreased morbidity and mortality compared with total PN. |
Use EN over PN in patients with a functioning gastrointestinal tract.12 | B | A systematic review of low-quality studies showed that EN may have fewer serious adverse events than PN. |
In critically ill patients who need nutrition support therapy, use EN instead of PN or a combination of the two.4,17–19 | A | A large randomized controlled trial and a systematic review of low-quality studies comparing EN and PN in critically ill patients showed no difference in 90-day mortality. However, using EN may result in fewer respiratory infections and shorter hospital stays, and it is more cost-effective. |
Consider using high-carbohydrate, high-protein, low-fat EN in patients with burns on more than 10% of their total body surface area.25 | B | A systematic review of low-quality studies showed that using a high-carbohydrate, high-protein, low-fat EN formula may result in a lower incidence of pneumonia compared with use of a low-carbohydrate, high-protein, high-fat diet. |
In patients with dementia, avoid tube feeding.32 | C | A nonsystematic review found no evidence that tube feeding improved outcomes. |

Recommendation | Sponsoring organization |
---|---|
Do not recommend percutaneous feeding tubes in patients with advanced dementia. | American Academy of Hospice and Palliative Medicine |
American Geriatrics Society | |
Do not insert percutaneous feeding tubes in individuals with advanced dementia. Instead, offer oral assisted feedings. | American Medical Directors Association |
Patient Assessment
A nutrition screening and assessment are required to determine an individual's nutrition status and the potential need for nutrition support therapy.1–4 Malnutrition is a deficiency, excess, or imbalance in an individual's intake of energy or nutrients; in this article, malnutrition is defined as conditions related to undernutrition. Table 1 provides selected tools for screening and identifying individuals at risk of malnutrition.5 There is insufficient evidence for using one tool vs. another; therefore, physicians should select a tool based on the patient and treatment setting.
Tool | Website |
---|---|
Community setting | |
Malnutrition Universal Screening Toola,c,d | https://www.bapen.org.uk/screening-and-must/must-calculator |
Inpatient setting/hospitalized patients | |
Malnutrition Screening Toola,b | https://abbottnutrition.com/tools-for-patient-care/rd-toolkit |
Nutritional Risk Screening 2002a,c,d | https://www.mdcalc.com/nutrition-risk-screening-2002-nrs-2002 |
Short Nutritional Assessment Questionnairea,b | https://www.fightmalnutrition.eu/toolkits/hospital-screening |
Older adults | |
Mini Nutritional Assessment–Short Forma,b,d | https://www.mna-elderly.com/mna-forms |
Modified Mini Nutritional Assessment–Short Forma,b,c,d |
If screening determines that a patient is at higher risk of malnutrition, then family physicians should work with a registered dietitian nutritionist who uses the Nutrition Care Process framework for assessment.6 This includes evaluating anthropometric measurements; biochemical data, medical tests, and procedures; food and nutrition history; nutrition-focused physical findings; and patient history.
To determine if patients are meeting energy needs, physicians can use body weight, height, and age, with additional energy needs included for activity and metabolic needs for specific medical problems.7–9 An average adult requires 25 to 30 kcals per kg of body weight and 1 to 2 g of protein per kg of body weight, but family physicians should use a predictive formula such as the Mifflin-St Jeor equation and consult with a registered dietitian nutritionist when possible (Table 2).7,9

Estimating energy needs using the Mifflin-St Jeor equation* | |||
---|---|---|---|
Males | |||
RMR† = 9.99 × weight (kg) + 6.25 × height (cm) − 4.92 × age + 5 | |||
Females | |||
RMR† = 9.99 × weight (kg) + 6.25 × height (cm) − 4.92 × age − 161 | |||
Estimating protein needs | |||
Condition | Protein in g (based on body weight in kg) | ||
Healthy adult | 0.8 | ||
Adults > 65 years | 1.0 | ||
Bariatric | 1.0 to 1.5 (ideal body weight) | ||
Chronic kidney disease (for hemodialysis or peritoneal dialysis) | 1.2 to 1.5 | ||
Chronic kidney disease (nondialysis) | 0.6 to 0.75 | ||
Critical illness | 1.2 to 2.0 | ||
Heart failure | 1.12 to 1.37 | ||
Hepatic disease | 1.0 to 1.2 (dry weight) | ||
1.2 to 1.5 (dry weight malnourished) | |||
Hepatitis or cirrhosis without encephalopathy | 0.8 to 1.0 | ||
Obesity | 2.0 (ideal body weight for obese classes 1 and 2) | ||
2.5 (ideal body weight for obese classes 3 and 4) | |||
Pressure injury | 1.2 to 1.5 | ||
Respiratory disease | 1.2 to 1.6 (maintenance) | ||
1.6 to 2.0 (for repletion) | |||
2.0 (ideal body weight for BMI of 30 to 40 kg per m2) | |||
2.5 (ideal body weight for BMI > 40 kg per m2) | |||
Estimating fluid needs | |||
Method 1 (based on energy intake) 1 mL of fluid per kcal Method 2 (based on age weight [e.g., Holliday-Segar formula]) | Method 3 (based on nitrogen and energy intake) 1 mL per kcal + 100 mL and body per g of nitrogen Method 4 (based on total body surface area) 1,500 mL per m2 | ||
Age (years) | Body weight | ||
16 to 30 | 35 to 40 mL per kg | ||
31 to 54 | 30 to 35 mL per kg | ||
55 to 65 | 30 mL per kg | ||
> 65 | 25 mL per kg |
Indications for Nutrition Support Therapy
Universal indications for nutrition support are controversial because of the lack of good-quality studies with patient-oriented outcomes.10,11 A Cochrane review of low-quality studies found no evidence of a mortality benefit or an increase in harm with nutrition support.12 However, there is better evidence for nutrition support therapy in some GI conditions. A Cochrane review showed that early EN support after lower GI surgery decreased the length of hospital stay but had no effect on other outcomes; therefore, physicians should consider initiating EN within 24 hours of lower GI surgery.13 In nonsevere acute pancreatitis, physicians should initiate early oral feeding and use EN if nutrition support therapy is needed.14,15 Beyond these conditions, physicians should perform a nutritional assessment to decide if nutrition support is needed.
Patients may benefit from nutrition support if they are malnourished, at risk of malnutrition, or nourished but unable to meet estimated nutritional needs orally for more than five days.4 However, before initiating therapy, family physicians should determine goals for treatment, prognosis, and overall quality of life. Figure 1 provides an algorithm to help determine appropriateness and a potential route of administration for nutrition support.16

Enteral vs. Parenteral Nutrition Support
Research supports using EN over PN if an individual's GI system is functioning because EN generally has fewer adverse effects and may have better outcomes.1,4,12 Studies comparing EN and PN in critically ill patients did not show a difference in 90-day mortality; however, EN was associated with fewer respiratory infections and shorter hospital stays, and it was more cost-effective.4,17–19 Hospitals that use a nutrition support team to regulate the use of PN may have lower rates of inappropriate PN use.20
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