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Am Fam Physician. 2022;105(3):324-326

Published online February 18, 2022.

This clinical content conforms to AAFP criteria for CME.

Author disclosure: No relevant financial relationships.

Key Points for Practice

• Vaccination against hepatitis B is recommended for all adults up to 59 years of age.

• The 15- and 20-valent PCVs are recommended for all adults 65 years and older and younger adults with risk factors. Those who receive the 15-valent vaccine should also receive the 23-valent PPSV.

• In addition to adults older than 50 years, recombinant zoster immunization is recommended for people 19 years and older with immunosuppression.

From the AFP Editors

The 2022 adult and child/adolescent immunization schedules have been approved by the Advisory Committee on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention (CDC) and are accessible at These schedules now combine links to COVID-19 vaccination information, Vaccination Information Statements, adverse event reporting, and a QR code for online schedules. Notable changes to the child/adolescent schedule include the addition of dengue vaccine recommendations, whereas the adult schedule has been updated with the 15-and 20-valent pneumococcal conjugate vaccines (PCV15, PCV20) in place of the 13-valent pneumococcal conjugate vaccine (PCV13), recombinant zoster vaccine recommendations for immunocompromised adults, and changes to hepatitis B recommendations.

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Coverage of guidelines from other organizations does not imply endorsement by AFP or the AAFP.

This series is coordinated by Michael J. Arnold, MD, associate medical editor.

A collection of Practice Guidelines published in AFP is available at

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