
Am Fam Physician. 2022;105(4):366-367
Author disclosure: No relevant financial relationships.
Clinical Question
Is cilostazol (Pletal) therapy safe and effective for improving walking distance in patients with intermittent claudication due to peripheral artery disease (PAD)?
Evidence-Based Answer
Cilostazol improves initial and absolute walking distances in patients with intermittent claudication secondary to PAD and appears to be equivalent in effect to pentoxifylline (Trental). Adverse effects of cilostazol include headache, diarrhea, dizziness, and palpitations.1 (Strength of Recommendation: A, meta-analysis with consistent results.)
Practice Pointers
PAD affects up to 12% of people 55 to 69 years of age and 20% of people older than 70 years.1 A sensation of heaviness and fatigue in the leg muscles, known as vascular claudication, is present in 60% of patients with PAD.2,3 Intermittent claudication secondary to PAD is an indicator of increased systemic atherosclerosis. Compared with age-matched controls, patients who experience intermittent claudication have a higher risk of amputation and cardiovascular mortality over five years.4
Subscribe
From $165- Immediate, unlimited access to all AFP content
- More than 130 CME credits/year
- AAFP app access
- Print delivery available
Issue Access
$59.95- Immediate, unlimited access to this issue's content
- CME credits
- AAFP app access
- Print delivery available