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Am Fam Physician. 2023;107(4):online

Author disclosure: No relevant financial relationships.

Details for This Review

Study Population: 22,052 adults who smoke combustible cigarettes

Efficacy End Points: Smoking cessation at six months to one year

Harm End Points: Adverse events or serious adverse events at one week or longer

1 in 25 was helped (quit smoking, compared with nicotine replacement therapy)1 in 7 was harmed (experienced adverse events, compared with behavior therapy alone or no intervention)
1 in 15 was helped (quit smoking, compared with non-nicotine electronic cigarettes)
1 in 50 was helped (quit smoking, compared with behavior therapy only or no intervention)

Narrative: Cigarette smoking is the leading cause of preventable death in the United States.1 More than 43 million people 12 years or older report smoking cigarettes in the previous month, with an estimated 480,000 deaths annually attributed to cigarette smoking in the United States.1,2 Although behavior support and pharmacologic treatment such as nicotine replacement therapy (NRT) are available for smoking cessation treatment, long-term abstinence is challenging for people who are dependent on tobacco. An electronic cigarette (e-cigarette) is a mobile device for inhaling aerosol formed by heating a liquid through a battery-powered heating coil. e-Cigarettes may aid in smoking cessation because they uniquely offer the sensory, behavior, and social aspects of smoking while providing nicotine.

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This series is coordinated by Christopher W. Bunt, MD, AFP assistant medical editor, and the NNT Group.

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