brand logo

Am Fam Physician. 2015;91(4):243-249

A more recent article on hemoptysis is available.

Author disclosure: No relevant financial affiliations.

Hemoptysis is the expectoration of blood from the lung parenchyma or airways. The initial step in the evaluation is determining the origin of bleeding. Pseudohemoptysis is identified through the history and physical examination. In adults, acute respiratory tract infections (e.g., bronchitis, pneumonia), bronchiectasis, asthma, chronic obstructive pulmonary disease, and malignancy are the most common causes. Tuberculosis is a major cause of hemoptysis in endemic regions of the world. Although tuberculosis rates are low in the United States, they are increased in persons who are homeless or who were born in other countries; consideration for testing should be made on an individual basis. Hemodynamic instability, abnormal gas exchange, cardiopulmonary comorbidities, and lesions at high risk of massive bleeding warrant inpatient evaluation. Chest radiography is recommended as the initial diagnostic test for hemodynamically stable patients with hemoptysis. Further evaluation with computed tomography with or without bronchoscopy is recommended in patients with massive hemoptysis, those with abnormal radiographic findings, and those with risk factors for malignancy despite normal radiographic findings.

Hemoptysis is defined as the expectoration of blood from the lung parenchyma or airways. The volume of blood produced has traditionally been used to differentiate between nonmassive and massive hemoptysis; the cutoff value ranges from 100 to 600 mL of blood produced in a 24-hour period.1,2 For the purposes of this article, expectoration of more than 200 mL of blood per 24 hours is considered massive hemoptysis.3 Because of the practical difficulties of quantifying the volume of expectorated blood, others have proposed the term life-threatening hemoptysis to indicate hemoptysis accompanied by measurable parameters, such as abnormal gas exchange and hemodynamic instability, for patients in need of urgent resuscitation and treatment.4,5

Clinical recommendationEvidence ratingReferenceComments
Chest radiography should be performed as part of the initial evaluation of patients with hemoptysis.C15 Recommendation from American College of Radiology consensus guidelines based on observational studies
CT is suggested for initial evaluation of patients at high risk of malignancy who have suspicious findings on chest radiography. CT should be considered in patients with risk factors (e.g., 40 years or older, smoking history of at least 30 pack-years) who have negative or nonlocalizing findings.C15 Recommendation from American College of Radiology consensus guidelines based on observational studies
Patients with negative findings on chest radiography, CT, and bronchoscopy (cryptogenic hemoptysis) have a low risk of malignancy and can be observed for three years. No specific recommendations can be made regarding chest CT or radiography during that interval, but imaging should be based on risk factors. If hemoptysis recurs, multidimensional CT angiography should be considered. Bronchoscopy may also complement imaging during the observation period.C15 Recommendation from American College of Radiology consensus guidelines based on observational studies

A study of 762,325 patients in a primary care database evaluated the incidence of hemoptysis as a presenting symptom in the outpatient setting.6 Hemoptysis occurred in 4,812 patients in a six-year period, for an incidence of approximately one case per 1,000 patients per year. Thus, a typical primary care physician could expect to encounter patients with the chief presenting symptom of hemoptysis four or five times per year. Massive hemoptysis accounts for a minority of cases (5% to 15%).5

Illustrative Cases


A 46-year-old man presents with a cough that has produced blood-streaked sputum for the past two days. Associated symptoms include rhinorrhea, congestion, and subjective fever. He estimates the total amount of blood loss to be less than 1 tablespoon. The medical history is unremarkable. He has never used tobacco and has not recently traveled, lost weight, or had night sweats.

Vital signs are within normal limits, and the patient appears to breathe comfortably, other than intermittent cough. No blood is produced in the clinic. Pulmonary examination demonstrates normal breath sounds. Nasal, oropharyngeal, cardiovascular, and abdominal examinations are unremarkable.


A 74-year-old woman presents to the emergency department after coughing up blood. She brings a container with approximately 100 mL of blood-tinged sputum produced over the past 24 hours. She reports that she has had similar episodes in the past, which were diagnosed as bronchitis, and that the symptoms resolved within a few days of initiating oral antibiotic therapy. Her medical history is significant for Sjögren syndrome, bronchiectasis, and microcytic anemia. She has a 50 pack-year smoking history and quit smoking five years ago. She does not drink alcohol. She has lost 40 lb (18 kg) over the past 12 months.

Vital signs at the time of presentation include a temperature of 99°F (37.2°C), blood pressure of 146/73 mm Hg, heart rate of 127 beats per minute, respiratory rate of 36 breaths per minute, and oxygen saturation of 83% in room air. Although the respiratory rate is increased, the patient does not appear to be in distress. Nasal examination demonstrates normal mucosa without epistaxis. Oropharyngeal examination reveals normal dentition and mucosa without signs of bleeding or ulceration. The neck is supple and without lymphadenopathy. Pulmonary examination reveals diffuse inspiratory rales. Cardiovascular examination is normal except for tachycardia. Abdominal examination is unremarkable.

Differential Diagnosis

The differential diagnosis of hemoptysis is broad (Table 11 ), and the relative frequency of possible etiologies varies significantly depending on the clinical setting. In outpatient primary care, acute respiratory tract infections, asthma, chronic obstructive pulmonary disease, malignancy, and bronchiectasis are the most common diagnoses in patients with hemoptysis.6 In comparison, a study of patients with hemoptysis in a tertiary referral center showed that bronchiectasis, lung cancer, bronchitis, and pneumonia account for more than 70% of inpatient diagnoses (Table 2).6,7 A likely explanation for the difference is that bronchiectasis and lung cancer are more likely to produce massive hemoptysis and lead to hospitalization.

Primary vascular source
Arteriovenous malformation
Pulmonary embolism
Elevated pulmonary venous pressure
Pulmonary artery rupture
Upper airway source
Gastrointestinal source
Serratia marcescens (gram-negative bacterium that produces a red pigment that may be mistaken for blood)
Pulmonary parenchymal source
Lung abscess
Lung contusion
Mycetoma (“fungus ball”)
Idiopathic pulmonary hemosiderosis
Wegener granulomatosis
Lupus pneumonitis
Goodpasture syndrome
Tracheobronchial source
Airway trauma
Foreign body
Miscellaneous and rare causes
Systemic coagulopathy or thrombolytic agents
Catamenial hemoptysis (pulmonary endometriosis)
EtiologyFrequency (%)
Outpatient (U.K. Primary Care Cohort)6
Acute respiratory tract infection64
Chronic obstructive pulmonary disease8
Lung cancer6
Pulmonary embolism1
Bleeding disorder0.3
Pulmonary edema0.2
Mitral valve stenosis0.1
Inpatient (Israel Inpatient Cohort)7
Lung cancer19
Congestive heart failure4
Hemorrhagic diathesis4

The likelihood of tuberculosis infection associated with hemoptysis varies throughout the world. Tuberculosis accounts for 7% to 85% of cases of massive hemoptysis, with the lowest incidence in the United States and highest incidence in South Africa.5 Pulmonary tuberculosis should be suspected in patients with respiratory symptoms and possible tuberculosis exposure, younger age, weight loss, and radiographic findings of cavitation, upper lobe infiltrates, or miliary pattern.8 Approximately 6% to 7% of tuberculosis cases in the United States occur in homeless persons,9 and the rate of tuberculosis in persons born outside the United States is 12 times that of U.S.-born persons.10 Uncommon but well-known causes of hemoptysis include pulmonary embolism, pulmonary endometriosis, Goodpasture syndrome, and foreign body aspiration.

History and Physical Examination

The initial history should focus on determining the anatomic origin of bleeding. Once sources of bleeding other than the lower respiratory tract have been excluded (Table 32,11 ), specific etiologies can be considered (Table 4).

EtiologyHistorical findingsPhysical examination findingsConfirmatory test or procedure
Serratia marcescens (gram-negative bacterium that produces a red pigment that may be mistaken for blood)Previous hospitalization, use of broad-spectrum antibiotics, mechanical ventilationNormalNo red blood cells in sputum; positive culture
Upper gastrointestinal tract sourceCoffee ground appearance (not bubbly or frothy), darker blood, nausea, vomiting, gastrointestinal diseaseEpigastric tenderness, signs of chronic liver disease (e.g., palmar erythema, spider angiomas, ascites, peripheral edema)Acidic blood pH, blood mixed with food particles, blood in nasogastric aspiration, esophagogastro-duodenoscopy, barium swallow
Upper respiratory tract sourceBleeding gums, epistaxis, little or no coughGingivitis; telangiectasias; ulceration; varices of the tongue, nose, nasopharynx, oropharynx, or hypopharynxNasopharyngoscopy if etiology is not apparent
FindingSuggested etiology
Anticoagulant useCoagulopathy
CoughBronchiectasis, COPD, foreign body, pneumonia, tuberculosis
FeverBronchitis, lung abscess, neoplasm, pneumonia, pulmonary embolism, tuberculosis
Heart disease (valvular or congestive heart failure)Congestive heart failure
ImmunosuppressionBronchitis, lung abscess, pneumonia, tuberculosis
Recent surgery or immobilizationPulmonary embolism
SmokingBronchitis, COPD, neoplasia
Sputum productionBronchiectasis, COPD, pneumonia, tuberculosis
TraumaAirway trauma, pulmonary embolism
Weight lossCOPD, neoplasia, tuberculosis

Physical examination should begin with determination of cardiopulmonary status and the need for resuscitation.12 Criteria for admission to the intensive care unit or for referral to a specialty center for expedited evaluation are available (Table 5).13 Hemodynamic instability, abnormal gas exchange, cardiopulmonary comorbidities, and lesions at high risk of massive bleeding warrant inpatient evaluation. A scoring system based on a retrospective analysis of 1,087 patients with hemoptysis can identify patients at risk of in-hospital mortality and assist with appropriate decision making (Table 6).14 Patients with a score greater than 2 should be directly admitted to the intensive care unit, and those with a score greater than 5 may require urgent interventional radiology.14

Etiology with high risk of bleeding (e.g., aspergillosis, lesions with pulmonary artery involvement)
Gas-exchange abnormalities (respiratory rate > 30 breaths per minute, oxygen saturation < 88% in room air, or need for high-flow oxygen [> 8 L per minute] or mechanical ventilation)
Hemodynamic instability (hemoglobin < 8 g per dL [80 g per L] or a decrease of more than 2 g per dL [20 g per L] from baseline, consumptive coagulopathy, or hypotension requiring fluid bolus or vasopressors)
Massive hemoptysis (> 200 mL per 48 hours or > 50 mL per episode in patients with chronic pulmonary disease)
Respiratory comorbidities (e.g., previous pneumonectomy, chronic obstructive pulmonary disease, cystic fibrosis)
Other comorbidities (e.g., ischemic heart disease, need for anticoagulation)
Chest radiography on admission shows involvement of two or more quadrants (1 point)
Chronic alcoholism (1 point)
Pulmonary artery involvement (1 point)
Aspergillosis (2 points)
Malignancy (2 points)
Mechanical ventilation required (2 points)


Diagnostic Strategy

Figures 1 and 2 outline a recommended approach to the evaluation and management of nonmassive hemoptysis.3,15 Chest radiography is typically recommended for all patients with hemoptysis, whereas chest computed tomography (CT) or bronchoscopy should be reserved for patients with abnormal radiographic findings, recurrent hemoptysis, or risk factors for cancer. These recommendations are consistent with criteria from the American College of Radiology (ACR; Table 7).15

Initial evaluation of patients with hemoptysis should include chest radiography
In patients at high risk of malignancy with normal findings on chest radiography, CT, and bronchoscopy:
Observation for three years may be considered
Radiography and CT should be performed at follow-up based on the patient's risk factors
Bronchoscopy may be performed in addition to imaging during the observation period
CT should be used for initial evaluation in patients at high risk of malignancy or with suspicious findings on chest radiography
CT should be considered in current or former smokers who have normal findings on chest radiography
Massive hemoptysis can be treated with surgery or percutaneous embolization; multidetector CT before embolization or surgery can define the source of hemoptysis; percutaneous embolization may be used initially to halt the hemorrhage before definitive surgery

Resolution of Cases


This patient has a history of minimal blood production, normal vital signs, and no hemodynamic instability or abnormal gas exchange. A focused history and physical examination should help identify etiologic clues. Chest radiography should be performed to help localize disease, determine the etiology, and guide further intervention, if necessary.15

If the radiographic findings are normal and an underlying cause is identified, no additional testing is required.15 However, one study of smokers presenting with hemoptysis and normal findings on chest radiography found a 9.6% incidence of malignancy within three years.16,17 Therefore, patients with normal findings on chest radiography who are at high risk of malignancy (40 years or older, with at least a 30 pack-year smoking history) should be evaluated with chest CT angiography or a noncontrasted study if the patient is allergic to contrast media.1517 The ACR makes the same evaluation recommendation for patients with at least 30 mL of hemoptysis who are not at increased risk of malignancy.15 The ACR recommends that patients with cryptogenic hemoptysis (negative findings on CT and bronchoscopy) be followed for three years, but it does not make specific recommendations regarding follow-up chest CT, bronchoscopy, or other imaging over that period. Instead, surveillance should be based on patient risk factors and clinical course.15

Patients with infiltrate detected on chest radiography and historical findings consistent with pneumonia should receive appropriate antibiotic therapy and repeat chest radiography in six to eight weeks. Resolution of hemoptysis and chest infiltrate indicates that acute lower respiratory tract infection was the cause. If hemoptysis or infiltrate persists, CT should be performed to evaluate for more serious disease. A mass warrants further CT evaluation for malignancy.16


This patient has signs of hemodynamic instability (tachycardia) and abnormal gas exchange (tachypnea and hypoxia), which warrant inpatient management. For patients with massive hemoptysis, consultation with a pulmonologist and admission to the intensive care unit are usually warranted.4,12,13,18 Resuscitation focusing on the airway, breathing, and circulation should be performed before diagnostic testing. Table 8 outlines suggested initial studies in the evaluation of patients with massive hemoptysis.

Blood typing and cross-matchFor patients with hemodynamic instability from blood loss or those in whom a complete blood count reveals anemia that warrants transfusion
Chest radiographyFor all patients with hemoptysis; may help localize bleeding and identify etiology; provides images for later comparison to evaluate resolution of disease
Coagulation studiesReasonable to obtain in patients with a history of coagulopathy or current anticoagulant use
Complete blood countReasonable to obtain in all patients with hemoptysis to rule out thrombocytopenia and to evaluate for anemia and/or microcytosis indicative of chronic blood loss or malignancy
Renal function testingShould be obtained before imaging with contrast media and in patients with suspected vasculitis
Sputum testing (Gram stain, acid-fast bacilli smear, fungal cultures, cytology)Should be obtained if massive hemoptysis or an infectious etiology is suspected

Chest radiography may provide clues about the etiology, as well as guide further resuscitation and evaluation. Once the bleeding site has been determined, the patient should be placed in the lateral decubitus position with the affected lung down to prevent pooling of blood in the unaffected bronchial system. Rapid bleeding warrants immediate airway control with rigid bronchoscopy or endotracheal intubation.5 Flexible bronchoscopy is less effective in maintaining a patent airway, but can provide useful diagnostic information. For stable patients with no identifiable lesion on chest radiography or bronchoscopy, chest CT angiography and/or bronchial artery arteriography with or without embolization should be performed to guide treatment. Bronchial artery arteriography is usually reserved for cases in which embolization is planned, and is often performed after CT angiography, which aids in localization of bleeding.15 Table 9 lists the sensitivities of diagnostic tests for hemoptysis.5,14

Detecting bleeding site (%)Identifying etiology (%)
Bronchoscopy73 to 93*2.5 to 8
Chest radiography33 to 8235
Computed tomography70 to 8860 to 77
Multidetector computed tomography100 (bronchial arteries)Not available
62 (nonbronchial systemic arteries)

Data Sources: PubMed and OVID were searched using the key terms hemoptysis, evaluation, management, and adult from 2005 to 2014. The search included meta-analyses, randomized controlled trials, clinical trials, and reviews. Additional searches included the Cochrane Database of Systematic Reviews and the National Guideline Clearinghouse. Search dates: April 15, 2012, and September 3, 2014.

The authors thank Jordan Mastrodonato, MS, certified medical illustrator, for assistance with the preparation of the manuscript.

The views expressed in this abstract/manuscript are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. government.

Continue Reading

More in AFP

More in PubMed

Copyright © 2015 by the American Academy of Family Physicians.

This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.  See permissions for copyright questions and/or permission requests.