• Articles

    Caring for Transgender and Gender-Diverse Persons: What Clinicians Should Know

    David A. Klein, Scott L. Paradise, Emily T. Goodwin

    Transgender persons are those whose experienced or expressed gender differs from their sex assigned at birth. Transgender and gender-diverse persons may have gender dysphoria and often face substantial health care disparities and barriers to care. Depending on their comfort...

    Dental Problems in Primary Care

    Mark B. Stephens, Joseph P. Wiedemer, George M. Kushner

    Early childhood caries is the most common chronic condition in American children. Certain illicit and prescription drugs increase the risk of enamel erosion and caries formation in adults. Risk factors for periodontal disease include smoking, diabetes mellitus, and human...

    Crohn's Disease: Diagnosis and Management

    Brian Veauthier, Jaime R. Hornecker

    Crohn's disease is a chronic inflammatory condition causing lesions in the gastrointestinal tract and may result in extraintestinal complications. Genetic predispositions have been identified, and specific environmental factors have been associated with its development....

    AAFP News Now: AFP Edition

    AAFP News: AFP Edition

    CDC Provides Influenza Vaccination Updates, New Clinician Resources | Study: Obesity Associated with Risk of Early-Onset Colorectal Cancer in Women | AMA Policy Aims to Increase Patient Access to Sexual Assault Forensic Examinations | ACIP Changes Recommendations for...


    Faith in Subtraction: Deprescribing in Older Patient Facilitates Needed Surgery

    Martina Kelly

    Having faith and an open mind, even in the face of major health problems, can go a long way in helping patients reach their goals.


    The Responsibility of Family Physicians to Our Transgender Patients

    Sarah Stumbar

    To mitigate the health disparities experienced by transgender persons, family physicians must use the resources available to take the lead in meeting the medical and social needs of these patients.

    Cochrane for Clinicians

    Deep Venous Thrombosis: Home vs. Inpatient Treatment

    Cormac O'Connor, Aaron Saguil

    Patients treated at home with low-molecular-weight heparin (LMWH) have lower rates of recurrent VTE than those treated in a hospital.

    Preventing or Delaying Type 2 Diabetes Mellitus with Diet and Exercise

    Amy Crawford-Faucher

    There is moderate-quality evidence that in patients with impaired glucose tolerance (IGT) defined by an abnormal 75-g two-hour glucose tolerance test, implementing changes in diet and adding physical activity together can prevent or delay the development of type 2 diabetes.



    AFP uses the Strength-of-Recommendation Taxonomy (SORT),1 to label key recommendations in clinical review articles. In general, only key recommendations are given a Strength-of-Recommendation grade. Grades are assigned on the basis of the quality and consistency of available...

    FPIN's Help Desk Answers

    Wearable Devices for Weight Loss

    Kevin Stephens, Jr., Elise Morris

    There is conflicting evidence about the effectiveness of adding a wearable device to intensive lifestyle interventions for weight loss.

    Curbside Consultation

    Practical Considerations of Caring for Patients Abroad During Short-Term Medical Trips

    Victoria McCurry, Sommer Aldulaimi

    A 65-year-old woman presented on the second day of my week-long volunteer medical brigade to a migrant camp in Mexico. The patient had a blood pressure of 180/110 mm Hg and a heart rate of 78 beats per minute. Her presenting symptoms were itchy eyes and sneezing, which she...


    Incidental Findings Are Common with Chest CT and MRI of the Spine and Brain

    Allen F. Shaughnessy

    The risks of imaging, in addition to radiation exposure, include the identification of incidentalomas, which can lead to patient anxiety, further testing, and overtreatment. There is little research to guide what to do when they pop up on an imaging report (as the famous...

    Advance Care Planning Increases Execution of Advance Directives and Surrogate Decision-Maker Assignment

    Henry C. Barry

    In this study, an intensive advance care planning intervention dramatically increased the completion of advance directives and the identification of surrogate decision makers.

    Direct Oral Anticoagulants Preferred Over Warfarin for Nonvalvular Atrial Fibrillation in Patients Also Taking Low-Dose Aspirin

    Mark H. Ebell

    The balance of benefits and harms favors direct oral anticoagulants over warfarin (Coumadin) for patients with nonvalvular atrial fibrillation who require anticoagulation and are already taking low-dose aspirin.

    Mifepristone Pretreatment Improves Success Rate of Misoprostol for Early Pregnancy Loss

    Mark H. Ebell

    In women with early pregnancy loss between five and 12 weeks' gestation, pretreatment with 200 mcg of oral mifepristone before 800 mcg of vaginal misoprostol increases the likelihood of successful expulsion of the gestational sac.

    Photo Quiz

    Pruritic Rash on the Hands and Feet

    Jinal Gangar, Karthy Thiagarajan, Nandhini Veeraraghvan

    A woman presents with a pruritic rash that is associated with peeling and cracking of the palmar and plantar surfaces of her hands and feet.

    Practice Guidelines

    Lung Cancer Screening Recommendations from the ACCP

    Carrie Armstrong

    The American College of Chest Physicians (ACCP) recently published recommendations for lung cancer screening based on key questions developed using the PICO (population, intervention, comparator, and outcome) format.

    Medicine by the Numbers

    Early Invasive Management of Acute Coronary Syndromes

    Sally Liang, Michael Ritchie

    Does early invasive management help patients with unstable angina or acute non–ST-segment elevation myocardial infarction (NSTEMI) in reducing occurence of death, myocardial infarction, angina symptoms, and rehospitalization at six- to 12-month follow-up? Find out.

    Letters to the Editor

    Evidence Supporting Niacin Therapy Is More Nuanced Than Article States

    Does Niacin Have Cardiovascular Benefits in Patients with Dyslipidemia?

    Information from Your Family Doctor

    Common Dental Infections

    Dental caries (CARE-eez) are tooth infections caused by certain germs in the mouth. Caries destroy the enamel (hard outer layer) and dentin (bone-like tissue under the enamel) of the teeth. Dental caries are also called cavities or tooth decay. Caries that occur in young...

    Crohn's Disease

    It is a condition that causes long-term inflammation in the gastrointestinal (GI) tract. It can affect any part of the GI tract from mouth to anus. Crohn's disease usually happens in young adults, but it can also affect children and older adults. The exact cause of the...


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