Interpreting SARS-CoV-2 Diagnostic Tests: Common Questions and Answers

William D. Nettleton

The spectrum of asymptomatic, pre-symptomatic, and symptomatic SARS-CoV-2 transmission presents challenges for evaluating SARS-CoV-2 test performance for diagnostic or screening purposes and for interpreting test results. Molecular and antigen SARS-CoV-2 tests both have high...

Mifepristone and Misoprostol for Early Pregnancy Loss and Medication Abortion

Honor MacNaughton, Melissa Nothnagle, Jessica Early

Medication management of early pregnancy loss and medication abortion has become increasingly common. Medication abortion now accounts for 60% of all abortions completed before 10 weeks' gestation. Mifepristone and misoprostol are safe and effective for outpatient treatment...

Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders

Kenneth S. Yew, Kara A. Kamps-Schmitt, Robyn Borge

Hypermobile Ehlers-Danlos syndrome (EDS) and hypermobility spectrum disorders are the most common symptomatic joint hypermobility conditions. Hypermobile EDS is inherited in an autosomal dominant pattern, but it does not have a known genetic mutation; clinical features...

Key Recommendations on Managing Dyslipidemia for Cardiovascular Risk Reduction: Stopping Where the Evidence Does

Michael J. Arnold, Patrick G. O'Malley, John R. Downs

In June 2020, the third iteration of the U.S. Department of Veterans Affairs and Department of Defense guidelines on managing dyslipidemia was published. These recommendations create a simple, pragmatic, evidence-based approach that can be valuable to family physicians.

Diary of a Family Physician

Kyle B. Jones, Annette Chavez

First-person accounts from the front lines of family medicine.

Upper Gastrointestinal Bleeding, Genital Ulcers, Bacteriuria, Megestrol, Atopic Dermatitis

Key clinical questions and their evidence-based answers directly from the journal’s content, written by and for family physicians.

Screening for Hepatitis B Virus Infection in Adolescents and Adults

Iris Mabry-Hernandez, Nolan O'Dowd

This PPIP quiz is based on the recommendations of the USPSTF.

Screening for Hepatitis B Virus Infection in Adolescents and Adults: Recommendation Statement

The USPSTF recommends screening for hepatitis B virus infection in adolescents and adults at increased risk for infection.

Nerve Blocks for Pancreatic Cancer Pain

Andrea Silva, Thomas Wenstrup

Celiac plexus blocks can be used for pain associated with pancreatic cancer. They slightly reduce pain while decreasing opioid consumption, with fewer adverse effects compared with standard analgesic therapy.

Multifocal Pneumonia: Fever, Cough, and Dyspnea

Anitha E. Mathew, Josh Mugele

An 80-year-old patient presented to the emergency department with several days of increasing shortness of breath and abnormalities on a chest radiograph.

Elagolix, Estradiol, and Norethindrone Kit (Oriahnn) for the Management of Heavy Menstrual Bleeding Associated with Fibroids

Jumana Antoun

Oriahnn can decrease menstrual blood loss in premenopausal patients with uterine fibroids. Although it has been studied for only six months of use and may result in significant bone loss, it is labeled for up to two years of continuous therapy.

Dyslipidemia Management for Cardiovascular Disease Prevention: Guidelines from the VA/DoD

Michael J. Arnold, Andrew Buelt

The U.S. Department of Veterans Affairs and Department of Defense have updated recommendations for evaluation and management of dyslipidemia to prevent cardiovascular disease.

NAFLD in Children and Adolescents

Pascal J. de Caprariis, Ann DiMaio

Reply: Erin Westfall

Updated Statistics for Liver Biopsy Risk

Blaine Stott, John C. Dang

Reply: Erin Westfall

Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders

Hypermobility is when your joints are too flexible. Joints are areas of your body where two bones meet. Most joints bend, letting your body move. Some examples of joints are your shoulders, elbows, wrists, fingers, knees, ankles, and toes.