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Am Fam Physician. 2022;105(5):553-557

Related article: Sexually Transmitted Infections: Updates From the 2021 CDC Guidelines

This clinical content conforms to AAFP criteria for CME.

Author disclosure: No relevant financial relationships.

Key Points for Practice

• Most states permit expedited partner therapy, including provision of packaged medications or prescriptions without evaluation, to limit the spread of STIs.

• For chlamydial infections affecting the urethra, rectum, or pharynx, doxycycline, 100 mg orally twice daily for seven days, is most effective.

• For gonorrheal infection, ceftriaxone, 500 mg intra-muscularly as a single dose, is recommended for most people, with azithromycin cotreatment no longer recommended.

• For pelvic inflammatory disease, metronidazole is added to ceftriaxone and doxycycline treatment to eradicate anaerobic organisms.

From the AFP Editors

Evidence-based prevention and treatment of sexually transmitted infections (STIs) continue to evolve. The Centers for Disease Control and Prevention (CDC) released updated recommendations for STI management. These recommendations are summarized in a point-of-care application available at, and recommendations for providing quality STI clinical services are summarized at

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Coverage of guidelines from other organizations does not imply endorsement by AFP or the AAFP.

This series is coordinated by Michael J. Arnold, MD, associate medical editor.

A collection of Practice Guidelines published in AFP is available at

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