Should primary care clinicians recommend low-dose aspirin for the primary prevention of cardiovascular disease in adults 60 years or older?

The U.S. Preventive Services Task Force (USPSTF) recommends against initiating low-dose aspirin (81 mg per day) for the primary prevention of cardiovascular disease in adults 60 years or older (D recommendation). The USPSTF recommends shared decision-making for the initiation of low-dose aspirin for the primary prevention of cardiovascular disease in adults 40 to 59 years of age with a 10% or greater risk of cardiovascular disease and without an increased risk of bleeding (C recommendation).

POEMs; November 2022

Do nonsteroidal anti-inflammatory drugs prevent or delay fracture healing when used for pain management?

The use of nonsteroidal anti-inflammatory drugs for more than three days at higher doses during the postoperative or acute phase of fracture healing may lead to increased rates of nonunion, delayed union, and pseudarthrosis in adults, based on multiple systematic reviews of randomized controlled trials, cohort studies, and case-control trials.