Website maintenance is scheduled for Saturday, October 12, and Sunday, October 13. Short disruptions may occur during these days.

brand logo

Am Fam Physician. 2024;109(2):online

Author disclosure: No relevant financial relationships.

Details for This Review

Study Population: Nine randomized controlled trials from 16 high-income countries, including 3,424 adults with treatment-resistant depression (lack of response after at least two trials of antidepressant monotherapy) who met the Diagnostic and Statistical Manual of Mental Disorders, 4th and 5th eds., criteria for major depressive disorder and were having a current depressive episode

Efficacy End Points: Primary outcome: response to treatment (greater than 50% improvement in depressive symptoms on validated depression score) at eight weeks; secondary outcomes: response to treatment after two and 18 weeks, remission after eight weeks, social functioning or adjustment, health-related quality of life

Harm End Points: Primary outcomes: dropouts due to any cause or adverse effects at eight weeks; secondary outcomes: any adverse effects, specific adverse effects (e.g., akathisia [restlessness], weight gain)

Benefits
1 in 16 had positive response to treatment at eight weeks
1 in 22 had remission of depression at eight weeks
Harms
1 in 38 withdrew from the study due to any cause
1 in 58 withdrew from the study due to adverse effects
1 in 20 experienced akathisia or weight gain
Already a member/subscriber?  Log In

Subscribe

From $165
  • Immediate, unlimited access to all AFP content
  • More than 130 CME credits/year
  • AAFP app access
  • Print delivery available
Subscribe

Issue Access

$59.95
  • Immediate, unlimited access to this issue's content
  • CME credits
  • AAFP app access
  • Print delivery available
Purchase Access:  Learn More

Copyright ©2024 MD Aware, LLC (theNNT.com). Used with permission.

This series is coordinated by Christopher W. Bunt, MD, AFP assistant medical editor, and the NNT Group.

A collection of Medicine by the Numbers published in AFP is available at https:// www.aafp.org/afp/mbtn.

Continue Reading

More in AFP

More in PubMed

Copyright © 2024 by the American Academy of Family Physicians.

This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.  See permissions for copyright questions and/or permission requests.