• Articles

    Lead Poisoning in Children

    Laura Mayans

    Despite the implementation of primary prevention strategies in the United States such as banning lead in paint, gasoline, and plumbing, many children are still at risk of lead poisoning. In 2017, it was estimated that more than 500,000 U.S. children had blood lead levels of 5...

    Polypharmacy: Evaluating Risks and Deprescribing

    Anne D. Halli-Tierney, Catherine Scarbrough, Dana Carroll

    Polypharmacy, commonly defined as the use of at least five medications, can have negative consequences for both the patient and health care system. Risk factors for polypharmacy can be patient related, such as chronic conditions managed by multiple subspecialists,...

    Amenorrhea: A Systematic Approach to Diagnosis and Management

    David A. Klein, Scott L. Paradise, Rachel M. Reeder

    There are many underlying conditions that can lead to amenorrhea. Primary amenorrhea is the failure to reach menarche and requires evaluation if menarche has not occurred by 15 years of age or three years post-thelarche. Secondary amenorrhea is the cessation of regular menses...


    Evaluating Diagnostic Tests: Introducing a New Feature in AFP

    Kenneth W. Lin, Mark H. Ebell

    Since 2003, American Family Physician (AFP) has published an ongoing series of short articles that systematically evaluate the attributes of new drugs using the STEPS (Safety, Tolerability, Effectiveness, Price, and Simplicity) framework.1 Choosing an appropriate treatment is...

    Diagnostic Tests

    mSEPT9 Blood Test (Epi proColon) for Colorectal Cancer Screening

    Kenneth W. Lin

    Epi proColon is a blood test used for the detection of the methylated septin 9 (mSEPT9) gene. It is approved by the U.S. Food and Drug Administration (FDA) for colorectal cancer screening in people at average risk who have declined first-line screening tests.

    AFP Clinical Answers

    Migraine Headache, Hypertension in Children, CVD Risk, Acupuncture, Incarcerated Patients

    Key clinical questions and their evidence-based answers directly from the journal’s content, written by and for family physicians.

    Cochrane for Clinicians

    Noninvasive Diagnostic Tests for Helicobacter pylori Infection

    Anne Mounsey, Elizabeth A. Leonard

    Which noninvasive diagnostic test—urea breath test, serology, or stool antigen test—provides the most accurate diagnosis of Helicobacter pylori infection in symptomatic and asymptomatic patients?

    Medication Management for Chronic Heart Failure with Preserved Ejection Fraction

    Pamela O. Obi

    Mineralocorticoid receptor antagonists reduce hospitalizations for patients with HFpEF. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have not been shown to change the morbidity or mortality in patients with HFpEF.

    FPIN's Help Desk Answers

    Pharmacologic Therapy for Heart Failure

    Scott Christensen, Rebecca Davis

    Compared with monotherapy, the combination of an ACE inhibitor and an ARB has not been shown to improve cardiovascular or overall mortality in patients with symptomatic heart failure. The combination is associated with an increased number of adverse drug effects.

    Photo Quiz

    Symmetrical Reticulated Lower Extremity Rash

    Nisrine N. Makarem

    A healthy 30-year-old woman presented with a rash over both lower extremities (Figure 1) that began two months earlier. The rash was slightly itchy but not painful. She lived in a cold area and reported sitting in front of an electric heater for two to three hours daily over...

    Curbside Consultation

    Helping Patients Cope with Grief

    Stephen T. Dudley

    The loss of a loved one, especially a spouse or a child, is perhaps one of the most difficult events a person will experience in a lifetime. The resulting grief can be overwhelming and incapacitating for a time. Family physicians can be sources of comfort to those who grieve...

    Practice Guidelines

    Physical Activity: Updated Recommendations from HHS

    Carrie Armstrong

    The U.S. Department of Health and Human Services recently published updated recommendations on physical activity based on a systematic review of the effect of physical activity on health. The committee addressed 38 questions and 104 subquestions and graded the evidence based...

    Medicine by the Numbers

    Preventing Spontaneous Abortion with Progestin Therapy

    Patricia Van Leer

    The use of progestin therapy in women with recurrent pregnancy loss appears to reduce the incidence of spontaneous abortion, preterm labor, and stillbirth, and increase the rate of live birth. However, due to issues with the studies the authors were hesitant to give progestin...

    Letters to the Editor

    Lyme Disease As Possible Contributing Factor for Knee Pain

    Information from Your Family Doctor

    Lead Poisoning in Children

    Any detectable lead in the blood is abnormal. Even low blood lead levels can cause delays in brain development and behavior problems. High levels of lead can cause further problems in the brain, intestines, kidneys, and bone marrow.



    Incorrect evidence evaluation and study statistics. The FPIN's Help Desk Answers, “Wearable Devices for Weight Loss” (December 1, 2018, p. 670), contained two errors. The first was in the first sentence of the “Evidence-Based Answer” section (page 670), which should have read...


    All editors in a position to control content for this activity, AFP journal, are required to disclose any relevant financial relationships. View disclosures.

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