• Articles

    Hand-Foot-and-Mouth Disease: Rapid Evidence Review

    Aaron Saguil, Shawn F. Kane, Rebecca Lauters, Michael G. Mercado

    Hand-foot-and-mouth disease is most commonly caused by enterovirus 71 and coxsackievirus A16. Clinical diagnosis is based on the presentation of a low-grade fever with a maculopapular or papulovesicular rash on the hands and soles of the feet, and by painful oral ulcerations....

    Opioid Use Disorder: Medical Treatment Options

    Diana Coffa, Hannah Snyder

    Opioid use disorder, a chronic relapsing condition, is highly prevalent and can be fatal; in 2016, it affected at least 2.1 million Americans 12 years and older. Family physicians are positioned to diagnose opioid use disorder and provide evidence-based treatment. Patients...

    Anticoagulation: Updated Guidelines for Outpatient Management

    Patricia Wigle, Brad Hein, Christopher R. Bernheisel

    Vitamin K antagonists, unfractionated heparin, low-molecular-weight heparin, and direct oral anticoagulants are commonly used for the prevention and treatment of systemic embolism associated with atrial fibrillation, stroke, and venous thromboembolism. Low-molecular-weight...

    Progestin Therapy Not Likely to Be Harmful in Women with First Trimester Bleeding

    Carl Bryce, Erin Hendriks

    Original Article: First Trimester Bleeding: Evaluation and Management


    Common Misperceptions About Buprenorphine Prescribing for Opioid Use Disorder

    Stephen A. Martin, Lisa M. Chiodo, Amanda Wilson

    The antidote to the opioid use disorder epidemic is the thoughtful use of evidence-based medicine and an honest understanding of what we know—and what we don't know—about caring for people with substance use disorders.

    AFP Clinical Answers

    Uterine Fibroids, Traumatic Brain Injury, Treating Obesity, Breast Cancer Survivors

    Key clinical questions and their evidence-based answers directly from the journal's content, written by and for family physicians.

    Cochrane for Clinicians

    Antihypertensive Drug Therapy for Mild to Moderate Hypertension During Pregnancy

    Nicholas LeFevre, Ellisa Krumm

    Compared with placebo, antihypertensive drug therapy for mild to moderate hypertension (defined by the authors as a blood pressure of 140 to 169 mm Hg systolic or 90 to 109 mm Hg diastolic) caused by chronic hypertension, gestational hypertension, or preeclampsia during...

    Effectiveness and Safety of Factor Xa Inhibitors in Patients with Atrial Fibrillation

    Katherine Cocker, Aaron Saguil

    Treatment of AFib with a factor Xa inhibitor results in a decrease in the combined end point of stroke and embolic events (odds ratio [OR] = 0.89; 95% CI, 0.82 to 0.97), as well as a decrease in intracranial hemorrhage (OR = 0.50; 95% CI, 0.42 to 0.59) and all-cause mortality...

    Photo Quiz

    Painful Scrotal Swelling

    Vibhuti Ansar, Kihae Shin

    A 44-year-old man presented with worsening scrotal swelling that began two weeks prior. He also had sharp, constant pain that radiated to both legs (left more than right) and his buttocks. He rated it as 10 out of 10 on a pain scale. The pain worsened with urination and was...

    FPIN's Help Desk Answers

    Thickened Feedings for Infants with Gastroesophageal Reflux

    Alexander Finck, Laura Morris

    Bottle-fed infants with gastroesophageal reflux should be given thickened formula feedings.


    Protecting Patients from Elder Abuse Scams

    Leslie Ramirez, Jo Marie Reilly, Anthony Zamudio

    Protecting patients from elder abuse scams.


    Laboratory-Based Prediction Model Can Rule Out Serious Bacterial Infections in Febrile Infants

    Henry C. Barry

    In febrile infants up to 60 days of age, the combination of a normal urinalysis result, an absolute neutrophil count of less than 4,090 per mL (4.1 × 109 per L), and a serum procalcitonin level of less than 1.71 ng per mL is accurate at ruling out serious bacterial infections.

    Pneumatic Compression in Addition to Pharmacologic Thromboprophylaxis Does Not Further Reduce DVT Risk

    Nita Shrikant Kulkarni

    This study found no benefit to the addition of intermittent pneumatic compression to pharmacologic anticoagulation for the prevention of proximal DVT in critically ill patients.

    Oral Antibiotics Are Equal to IV Antibiotics for Serious Bone and Joint Infections

    Mark H. Ebell

    e-Cigarettes More Effective Than Nicotine Replacement for Cessation of Tobacco Use in Adults

    Mark H. Ebell

    Among adults who smoked a median of 15 cigarettes per day, those who were randomized to receive e-cigarettes were more likely to be abstinent at one year than those who received nicotine replacement (number needed to treat [NNT] = 12).

    Practice Guidelines

    Perinatal Depression: AAP Policy Statement on Recognition and Management

    Lisa Croke

    The American Academy of Pediatrics has released a policy statement regarding the integration of perinatal depression recognition and management into well-child visits.

    Medicine by the Numbers

    Antibiotics for Acute Rhinosinusitis in Adults

    Nathan Franck, Shahriar Zehtabchi

    Because of the relatively high rate of reported adverse effects and the high likelihood of resolution of symptoms with supportive care and symptomatic management, the authors recommend selective antibiotic use in patients with acute sinusitis. Read more.

    Letters to the Editor

    Importance of Dyslipidemia Screening in Children and Adolescents



    Updated Guideline and Terminology. The article, “Testosterone Therapy: Review of Clinical Applications” (October 1, 2017, p. 441) included a section titled, “Testosterone Therapy in Female-to-Male Transgender Patients” beginning on page 447, which was based on information...


    All editors in a position to control content for this activity, AFP journal, are required to disclose any relevant financial relationships. View disclosures.

    Tag Legend


    CME Continuing Medical Education Credit
    POC Point-of-Care Resource
    FREE Free Access
    Alg Algorithm
    DDx Differential Diagnosis
    PtEd Patient Education