• Articles

    Managing Hypertension Using Combination Therapy

    Dustin K. Smith, Robert P. Lennon, Peter B. Carlsgaard

    Most adults with primary hypertension will eventually require at least two antihypertensive agents, either initially as combination therapy or as add-on therapy if monotherapy and lifestyle modifications do not achieve adequate blood pressure control. Four main classes of...

    Genital Ulcers: Differential Diagnosis and Management

    Michelle A. Roett

    Genital ulcers are infectious or noninfectious and are located on the vagina, penis, and anorectal or perineal areas. Herpes simplex virus is the most common cause for genital ulcers in the United States; diagnosis for the virus is made through physical examination and...

    Office Spirometry: Indications and Interpretation

    Robert C. Langan, Andrew J. Goodbred

    Spirometry may be used to monitor progression of lung disease and response to therapy. High-quality, office-based spirometry can be as useful and reliable as testing performed in a pulmonary function laboratory. A stepwise approach to spirometry should be used, including...


    Integrating Breast Cancer Risk Management into Primary Care

    Lauren Nye

    It is important that primary care physicians have the ability and resources to identify women eligible for genetic counseling and testing for breast cancer.

    AFP Clinical Answers

    Common Cold, IV Fluids for Children, e-Cigarettes, Postpartum Depression, Actinic Keratoses

    Key clinical questions and their evidence-based answers directly from the journal's content, written by and for family physicians.


    Esketamine (Spravato) for Treatment-Resistant Depression

    Mohamed Jalloh

    Esketamine is an in-office treatment for patients with a severe major depressive disorder to be used in addition to oral antidepressant therapy.

    Lown Right Care

    Fracture Prevention in Older Adults

    Ann Lindsay

    A collaboration between AFP and the Lown Institute promotes a vision of delivering health care that is based on the evidence, balanced in its approach, and focused on the patient.

    Putting Prevention Into Practice

    Medication Use to Reduce Risk of Breast Cancer

    Tina Fan, Adeola Fakolade

    This PPIP quiz is based on the recommendations of the USPSTF.

    Photo Quiz

    Conjunctival Lesion in a 10-Year-Old Girl

    Matthew Hawks, Megan Cook

    A 10-year-old girl presented with a lesion on her eye that appeared one month prior. The lesion was not painful, and she had no changes in her vision. Her medical history was unremarkable, including no eye trauma or injury. She had no history of contact lens use.

    Practice Guidelines

    Group B Streptococcus Disease: AAP Updates Guidelines for the Management of At-Risk Infants

    Lindsey Hoover

    Key Points for Practice

    U.S. Preventive Services Task Force

    Medication Use to Reduce Risk of Breast Cancer: Recommendation Statement

    The USPSTF recommends that clinicians offer to prescribe risk-reducing medications, such as tamoxifen, raloxifene, or aromatase inhibitors, to women who are at increased risk for breast cancer and at low risk for adverse medication effects.

    Letters to the Editor

    Evidence Lacking That Acupuncture Is More Effective Than Placebo

    Harriet A. Hall

    Reply: Robert B. Kelly

    Acupuncture Not Supported By Strong Scientific Evidence

    Joel R. Kann

    Replies: Robert B. Kelly; Christy J.W. Ledford, Paul F. Crawford III

    Information from Your Family Doctor

    Genital Ulcers: What Causes Them?

    They are sores found on the vagina or penis or in the surrounding areas. They are usually spread by vaginal, oral, or anal sexual contact. They can also be found in the anus or on the skin around it. Sometimes they hurt or leak fluid.


    All editors in a position to control content for this activity, AFP journal, are required to disclose any relevant financial relationships. View disclosures.

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