• Topic

    Genetics

    This collection features the best content from AFP, as identified by the AFP editors, on genetics and related issues, including family medical history, genetic testing, and specific syndromes (fetal alcohol spectrum disorders, fragile X syndrome, Down Syndrome, Klinefelter syndrome, Prader-Willi syndrome, Turner syndrome). New research may affect the interpretation and application of this material. Clinical judgment is advised. Note that AFP content published within the past two years is accessible to AAFP members and paid subscribers only.
    Categories
    Specific Syndromes
    Apr 15, 2022 Medical Care for Adults With Down Syndrome: Guidelines From the Global Down Syndrome Foundation [Practice Guidelines]
    Oct 15, 2017 Fetal Alcohol Syndrome and Fetal Alcohol Spectrum Disorders   DDx   PtEd   Tool
    Jun 15, 2015 Role of the Family Physician in the Management of Cystic Fibrosis [Editorials]
    Dec 15, 2014 Role of the Family Physician in the Care of Children with Down Syndrome   PtEd
    Jan 01, 2014 Noonan Syndrome   PtEd
    Nov 01, 2012 When to Suspect a Genetic Syndrome
    Aug 01, 2007 Turner Syndrome: Diagnosis and Management
    Dec 01, 2005 Klinefelter Syndrome
    Sep 01, 2005 Prader-Willi Syndrome
    Pharmacogenetics
    Nov 15, 2021 Should Allele Testing Be Done Before Prescribing Allopurinol to Prevent Severe Cutaneous Adverse Reactions? [FPIN's Clinical Inquiries]
    Jul 15, 2021 Pharmacogenetic Gene-Drug Associations: FDA Perspective on What Physicians Need to Know [Editorials]
    Jul 15, 2021 GeneSight Psychotropic Genetic Testing for Psychiatric Medication Selection [Diagnostic Tests]
    Nov 01, 2019 Allopurinol Hypersensitivity Assay HLA-B*58:01 Genotyping [Diagnostic Tests]
    Oct 01, 2015 Pharmacogenetics: Using Genetic Information to Guide Drug Therapy
    Jun 01, 2008 Genetic Factors in Drug Metabolism
    Aug 01, 2007 The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse Effects
    Counseling, Testing, and Risk Assessment

    General

    Apr 15, 2020 Fetal Aneuploidy: Screening and Diagnostic Testing   PtEd
    Jan 01, 2019 Inborn Errors of Metabolism: From Preconception to Adulthood
    May 01, 2018 Clinical and Personal Utility of Genetic Risk Testing [Curbside Consultation]
    Jan 15, 2015 Screening for Hereditary Cancer Syndromes [Curbside Consultation]
    Jan 15, 2009 Fetal Chromosomal Abnormalities: Antenatal Screening and Diagnosis   PtEd   Tool
    Feb 01, 2006 At-Home Genetic Tests [Curbside Consultation]
    Aug 01, 2005 Genomic Medicine for Underserved Minority Populations in Family Medicine [Editorials]

    Specific Conditions

    Dec 15, 2009 ACOG Guidelines for Managing Hereditary Breast and Ovarian Cancer Syndrome [Practice Guidelines]
    Feb 15, 2008 Cancer Genetic Risk Assessment for Individuals at Risk of Familial Breast Cancer [Cochrane for Clinicians]
    Jun 01, 2007 Screening for Hemochromatosis: Recommendation Statement [U.S. Preventive Services Task Force]
    Editorials and Letters
    Nov 15, 2024 Navigating Polygenic Risk Scores in Primary Care: Challenges and Considerations for Diverse Populations [Editorials]   FREE
    Oct 01, 2015 Pharmacogenetic Testing—An Unfulfilled Promise [Editorials]
    Apr 15, 2010 Family History and Genetic Testing for Cancer Risk [Letters to the Editor]
    Dec 01, 2009 The CDC's EGAPP Initiative: Evaluating the Clinical Evidence for Genetic Tests [Editorials]
    Aug 01, 2007 Is Genetic Testing for Cytochrome P450 Polymorphisms Ready for Implementation? [Editorials]
    Dec 15, 2005 Integrating Genetic Counseling into Family Medicine [Editorials]
    Jul 01, 2005 Genetic Testing: When to Test, When to Refer [Editorials]
    Patient Education, Self-Care
    Dec 15, 2014 Caring for Your Baby with Down Syndrome [Information from Your Family Doctor]   PtEd
    Jan 15, 2009 Prenatal Genetic Screening Tests [Information from Your Family Doctor]   PtEd
    Family History
    Aug 01, 2005 Family History: The Three-Generation Pedigree

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