References

  1. 1.Song P, Zha M, Yang Q, et al. The prevalence of adult attention-deficit hyperactivity disorder: a global systematic review and meta-analysis. J Glob Health. 2021;11:04009.
  2. 2.Williams OC, Prasad S, McCrary A, et al. Adult attention deficit hyperactivity disorder: a comprehensive review. Ann Med Surg (Lond). 2023;85(5):1802-1810.
  3. 3.Attoe DE, Climie EA. Miss. Diagnosis: a systematic review of ADHD in adult women. J Atten Disord. 2023;27(7):645-657.
  4. 4.Ohan JL, Visser TA. Why is there a gender gap in children presenting for attention deficit/hyperactivity disorder services? J Clin Child Adolesc Psychol. 2009;38(5):650-660.
  5. 5.Arnsten AFT. Guanfacine’s mechanism of action in treating prefrontal cortical disorders: successful translation across species. Neurobiol Learn Mem. 2020;176:107327.
  6. 6.Choi WS, Woo YS, Wang SM, et al. The prevalence of psychiatric comorbidities in adult ADHD compared with non-ADHD populations: a systematic literature review. PLoS One. 2022;17(11):e0277175.
  7. 7.Barbuti M, Maiello M, Spera V, et al. Challenges of treating ADHD with comorbid substance use disorder: considerations for the clinician. J Clin Med. 2023;12(9):3096.
  8. 8.Diagnostic and Statistical Manual of Mental Disorders, 5th ed., text revision. American Psychiatric Association; 2022.
  9. 9.Kessler RC, Adler L, Ames M, et al. The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population. Psychol Med. 2005;35(2):245-256.
  10. 10.Drechsler R, Brem S, Brandeis D, et al. ADHD: current concepts and treatments in children and adolescents. Neuropediatrics. 2020;51(5):315-335.
  11. 11.Ben-Dor Cohen M, Eldar E, Maeir A, et al. Emotional dysregulation and health related quality of life in young adults with ADHD: a cross sectional study. Health Qual Life Outcomes. 2021;19(1):270.
  12. 12.Kamradt JM, Eadeh HM, Nikolas MA. Sluggish cognitive tempo as a transdiagnostic link between adult ADHD and internalizing symptoms. J Psychopathol Behav Assess. 2022;44(3):699-712.
  13. 13.Philipsen A, Jans T, Graf E, et al. Effects of group psychotherapy, individual counseling, methylphenidate, and placebo in the treatment of adult attention-deficit/hyperactivity disorder: a randomized clinical trial. JAMA Psychiatry. 2015;72(12):1199-1210.
  14. 14.Ostinelli EG, Schulze M, Zangani C, et al. Comparative efficacy and acceptability of pharmacological, psychological, and neurostimulatory interventions for ADHD in adults: a systematic review and component network meta-analysis. Lancet Psychiatry. 2025;12(1):32-43.
  15. 15.Cortese S. Evidence-based prescribing of medications for ADHD: where are we in 2023? Expert Opin Pharmacother. 2023;24(4):425-434.
  16. 16.Macaluso M, Johnston C. Handbook of Practical Psychopharmacology. American Psychiatric Association Publishing; 2025.
  17. 17.National Institute for Health and Care Excellence. Attention deficit hyperactivity disorder: diagnosis and management. https://www.nice.org.uk/guidance/ng87
  18. 18.Nimmo-Smith V, Merwood A, Hank D, et al. Non-pharmacological interventions for adult ADHD: a systematic review. Psychol Med. 2020;50(4):529-541.
  19. 19.Mongia M, Hechtman L. Cognitive behavior therapy for adults with attention-deficit/hyperactivity disorder: a review of recent randomized controlled trials. Curr Psychiatry Rep. 2012;14(5):561-567.
  20. 20.Li L, Zhu N, Zhang L, et al. ADHD pharmacotherapy and mortality in individuals with ADHD. JAMA. 2024;331(10):850-860.
  1. 1.American Psychological Association. Trauma. https://www.apa.org/topics/trauma
  2. 2.Diagnostic and Statistical Manual of Mental Disorders, 5th ed., text revision. American Psychiatric Association; 2022.
  3. 3.Goldstein RB, Smith SM, Chou SP, et al. The epidemiology of DSM-5 posttraumatic stress disorder in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Soc Psychiatry Psychiatr Epidemiol. 2016;51(8):1137-1148.
  4. 4.Bassett D, Buchwald D, Manson S. Posttraumatic stress disorder and symptoms among American Indians and Alaska Natives: a review of the literature. Soc Psychiatry Psychiatr Epidemiol. 2014;49(3):417-433.
  5. 5.Sartor Z, Kelley L, Laschober R. Posttraumatic stress disorder: evaluation and treatment. Am Fam Physician. 2023;107(3):273-281.
  6. 6.Al Jowf GI, Ahmed ZT, Reijnders RA, et al. To predict, prevent, and manage post-traumatic stress disorder (PTSD): a review of pathophysiology, treatment, and biomarkers. Int J Mol Sci. 2023;24(6):5238.
  7. 7.Miao XR, Chen QB, Wei K, et al. Posttraumatic stress disorder: from diagnosis to prevention. Mil Med Res. 2018;5(1):32.
  8. 8.US Department of Veterans Affairs. PTSD: National Center for PTSD. https://www.ptsd.va.gov/professional/treat/essentials/complex_ptsd.asp
  9. 9.Guzman Torres E, Krause-Utz A, Sack M. Predictors of complex PTSD: the role of trauma characteristics, dissociation, and comorbid psychopathology. Borderline Personal Disord Emot Dysregul. 2023;10(1):1.
  10. 10.U.S. Department of Veterans Affairs. VA/DoD clinical practice guidelines. Management of posttraumatic stress disorder and acute stress disorder 2023. https://www.healthquality.va.gov/guidelines/MH/ptsd
  11. 11.Bisson JI, Roberts NP, Andrew M, et al. Psychological therapies for chronic post-traumatic stress disorder (PTSD) in adults. Cochrane Database Syst Rev. 2013;2013(12):CD003388.
  12. 12.Asmundson GJG, Thorisdottir AS, Roden-Foreman JW, et al. A meta-analytic review of cognitive processing therapy for adults with posttraumatic stress disorder. Cogn Behav Ther. 2019;48(1):1-14.
  13. 13.Schrader C, Ross A. A review of PTSD and current treatment strategies. Mo Med. 2021;118(6):546-551.
  14. 14.Scelles C, Bulnes LC. EMDR as treatment option for conditions other than PTSD: a systematic review. Front Psychol. 2021;12:644369.
  15. 15.Post-traumatic Stress Disorder. NICE guideline. National Institute for Health and Care Excellence; 2018.
  16. 16.Guina J, Rossetter SR, DeRhodes BJ, et al. Benzodiazepines for PTSD: a systematic review and meta-analysis. J Psychiatr Pract. 2015;21(4):281-303.
  17. 17.Wolfgang AS, Hoge CW. Cannabis and cannabinoids for pain and posttraumatic stress disorder in military personnel and veterans. JAMA Psychiatry. 2023;80(9):869-870.
  18. 18.Kline AC, Cooper AA, Rytwinksi NK, et al. Long-term efficacy of psychotherapy for posttraumatic stress disorder: a meta-analysis of randomized controlled trials. Clin Psychol Rev. 2018;59:30-40.
  19. 19.Salas J, Gebauer S, Gillis A, et al. Increased smoking cessation among veterans with large decreases in posttraumatic stress disorder severity. Nicotine Tob Res. 2022;24(2):178-185.
  20. 20.van den Berk Clark C, Kansara V, Fedorova M, et al. How does PTSD treatment affect cardiovascular, diabetes and metabolic disease risk factors and outcomes? A systematic review. J Psychosom Res. 2022;157:110793.
  1. 1.Diagnostic and Statistical Manual of Mental Disorders, 5th ed., text revision. American Psychiatric Association; 2022.
  2. 2.Angstman KB, Rasmussen NH. Personality disorders: review and clinical application in daily practice. Am Fam Physician. 2011;84(11):1253-1260.
  3. 3.Zhan Yuen Wong N, Barnett P, Sheridan Rains L, et al. Evaluation of international guidance for the community treatment of ‘personality disorders’: a systematic review. PLoS One. 2023;18(3):e0264239.
  4. 4.Krueger RF, Hobbs KA. An overview of the DSM-5 alternative model of personality disorders. Psychopathology. 2020;53(3-4):126-132.
  5. 5.Waugh MH, Hopwood CJ, Krueger RF, et al. Psychological assessment with the DSM-5 alternative model for personality disorders: tradition and innovation. Prof Psychol Res Pr. 2017;48(2):79-89.
  6. 6.Żerdziński M, Burdzik M, Dębski P, et al. The impact of obsessive-compulsive personality disorder on obsessive-compulsive disorder: clinical outcomes in the context of bipolarity. Front Psychiatry. 2025;16:1532966.
  7. 7.Pinto A, Steinglass JE, Greene AL, et al. Capacity to delay reward differentiates obsessive-compulsive disorder and obsessive-compulsive personality disorder. Biol Psychiatry. 2014;75(8):653-659.
  8. 8.Grassi G, Pallanti S, Righi L, et al. Think twice: impulsivity and decision making in obsessive-compulsive disorder. J Behav Addict. 2015;4(4):263-272.
  9. 9.Clemente MJ, Martins Silva AS, Pozzolo Pedro MO, et al. A meta-analysis and meta-regression analysis of the global prevalence of obsessive-compulsive personality disorder. Heliyon. 2022;8(7):e09912.
  10. 10.Pinto A, Teller J, Wheaton MG. Obsessive-compulsive personality disorder: a review of symptomatology, impact on functioning, and treatment. Focus (Am Psychiatr Publ). 2022;20(4):389-396.
  11. 11.Ekselius L, von Knorring L. Personality disorder comorbidity with major depression and response to treatment with sertraline or citalopram. Int Clin Psychopharmacol. 1998;13(5):205-211.
  12. 12.Volavka J, Neziroglu F, Yaryura-Tobias JA. Clomipramine and imipramine in obsessive-compulsive disorder. Psychiatry Res. 1985;14(1):85-93.
  13. 13.Caligor E, Levy KN, Yeomans FE. Narcissistic personality disorder: diagnostic and clinical challenges. Am J Psychiatry. 2015;172(5):415-422.
  14. 14.Ronningstam E. Intersect between self-esteem and emotion regulation in narcissistic personality disorder—implications for alliance building and treatment. Borderline Personal Disord Emot Dysregul. 2017;4:3.
  15. 15.Russ E, Shedler J, Bradley R, et al. Refining the construct of narcissistic personality disorder: diagnostic criteria and subtypes. Am J Psychiatry. 2008;165(11):1473-1481.
  16. 16.Weinberg I, Ronningstam E. Narcissistic personality disorder: progress in understanding and treatment. Focus (Am Psychiatr Publ). 2022;20(4):368-377.
  17. 17.Leichsenring F, Heim N, Leweke F, et al. Borderline personality disorder: a review. JAMA. 2023;329(8):670-679.
  18. 18.Palmer BA, Pahwa M, Geske JR, et al. Self-report screening instruments differentiate bipolar disorder and borderline personality disorder. Brain Behav. 2021;11(7):e02201.
  19. 19.Mendez-Miller M, Naccarato J, Radico JA. Borderline personality disorder. Am Fam Physician. 2022;105(2):156-161.
  20. 20.May JM, Richardi TM, Barth KS. Dialectical behavior therapy as treatment for borderline personality disorder. Ment Health Clin. 2016;6(2):62-67.
  21. 21.Sinnaeve R, van den Bosch LMC, Hakkaart-van Roijen L, et al. Effectiveness of step-down versus outpatient dialectical behaviour therapy for patients with severe levels of borderline personality disorder: a pragmatic randomized controlled trial. Borderline Personal Disord Emot Dysregul. 2018;5:12.
  22. 22.Cohen D, Lau K, Lau S. Effect of psychotherapy on patients with borderline personality disorder. Am Fam Physician. 2022;106(4):381-382.
  23. 23.Chanen AM, Betts JK, Jackson H, et al. Effect of 3 forms of early intervention for young people with borderline personality disorder: the MOBY randomized clinical trial. JAMA Psychiatry. 2022;79(2):109-119.
  1. 1.World Health Organization. International Classification of Diseases 11th Revision (ICD-11). https://icd.who.int/en
  2. 2.Diagnostic and Statistical Manual of Mental Disorders, 5th ed., text revision. American Psychiatric Association; 2022.
  3. 3.Griswold KS, Del Regno PA, Berger RC. Recognition and differential diagnosis of psychosis in primary care. Am Fam Physician. 2015;91(12):856-863.
  4. 4.Maj M, van Os J, De Hert M, et al. The clinical characterization of the patient with primary psychosis aimed at personalization of management. World Psychiatry. 2021;20(1):4-33.
  5. 5.Arciniegas DB. Psychosis. Continuum (Minneap Minn). 2015;21(3 Behavioral Neurology and Neuropsychiatry):715-736.
  6. 6.Preda A, Blackman G. Assessment of psychosis. BMJ Best Practicehttps://bestpractice.bmj.com/topics/en-us/1066
  7. 7.Berendsen S, van der Veen NM, van Tricht MJ, et al. Psychometric properties of the DSM-5 clinician-rated dimensions of psychosis symptom severity. Schizophr Res. 2020;216:416-421.
  8. 8.Boland R, Verduin ML, Ruiz P. Kaplan & Sadock’s Synopsis of Psychiatry, 12th ed. Lippincott Williams & Wilkins; 2021.
  9. 9.Lieberman JA, First MB. Psychotic disorders. N Engl J Med. 2018;379(3):270-280.
  10. 10.Marconi A, Di Forti M, Lewis CM, et al. Meta-analysis of the association between the level of cannabis use and risk of psychosis. Schizophr Bull. 2016;42(5):1262-1269.
  11. 11.Glasner-Edwards S, Mooney LJ. Methamphetamine psychosis: epidemiology and management. CNS Drugs. 2014;28(12):1115-1126.
  12. 12.Rahim MJ, Ghazali WS. Psychosis secondary to tuberculosis meningitis. BMJ Case Rep. 2016;2016:bcr2015213171.
  13. 13.Igata J, Okamoto N, Tesen H, et al. Human immunodeficiency virus-related neurocognitive disorder with hallucinations and delusions: a case report. Psychiatry Research Case Reports. 2024(3):100201.
  14. 14.Cheng JS, Hu JH, Chang MY, et al. Hepatitis C-associated late-onset schizophrenia: a nationwide, population-based cohort study. J Psychiatry Neurosci. 2021;46(6):E583-E591.
  15. 15.Faccioli J, Nardelli S, Gioia S, et al. Neurological and psychiatric effects of hepatitis C virus infection. World J Gastroenterol. 2021;27(29):4846-4861.
  16. 16.National CJD Research & Surveillance Unit. 32nd Annual Report 2023 Creutzfeldt-Jakob Disease Surveillance in the UKhttps://cjd.ed.ac.uk/sites/default/files/2025-01/Latest%20NCJDRSU%20annual%20report%2C%20covering%20the%20period%201990-2023.pdf
  17. 17.Aarsland D. Epidemiology and pathophysiology of dementia-related psychosis. J Clin Psychiatry. 2020;81(5):AD19038BR1C.
  18. 18.Ffytche DH, Creese B, Politis M, et al. The psychosis spectrum in Parkinson disease. Nat Rev Neurol. 2017;13(2):81-95.
  19. 19.Nadkarni S, Arnedo V, Devinsky O. Psychosis in epilepsy patients. Epilepsia. 2007;48(suppl 9):17-19.
  20. 20.Kim JS, Hong SB, Park KW, et al. Psychotic symptoms in patients with major neurological diseases. J Clin Neurol. 2024;20(2):153-165.
  21. 21.Jurado-Flores M, Warda F, Mooradian A. Pathophysiology and clinical features of neuropsychiatric manifestations of thyroid disease. J Endocr Soc. 2022;6(2):bvab194.
  22. 22.Laurinaitienė K, Steiblienė V. Testosterone levels in patients with psychosis versus healthy subjects. Nordic Journal of Psychiatry. 2021;75(suppl 1):S19.
  23. 23.Baldaçara L, Ramos A, Castaldelli-Maia JM. Managing drug-induced psychosis. Int Rev Psychiatry. 2023;35(5-6):496-502.
  24. 24.Reus VI, Fochtmann LJ, Eyler AE, et al. The American Psychiatric Association practice guideline on the use of antipsychotics to treat agitation or psychosis in patients with dementia. Am J Psychiatry. 2016;173(5):543-546.
  25. 25.Gerhard T, Huybrechts K, Olfson M, et al. Comparative mortality risks of antipsychotic medications in community-dwelling older adults. Br J Psychiatry. 2014;205(1):44-51.
  26. 26.Stahl SM. Clozapine. Prescriber’s Guide: Stahl’s Essential Psychopharmacology. Cambridge University Press; 2024:191-200.
  27. 27.Rogers JP, Zandi MS, David AS. The diagnosis and treatment of catatonia. Clin Med (Lond). 2023;23(3):242-245.
  28. 28.Arnold MJ. Management of first-episode psychosis and schizophrenia: guidelines from the VA/DoD. Am Fam Physician. 2024;109(5):482-483.
  29. 29.Haidary HA, Padhy RK. Clozapine. StatPearlshttps://www.ncbi.nlm.nih.gov/books/NBK535399/
  30. 30.Montastruc J-L, Lafaurie M, de Canecaude C, et al. Fatal adverse drug reactions: a worldwide perspective in the World Health Organization pharmacovigilance database. Br J Clin Pharmacol. 2021;87(11):4334-4340.
  31. 31.Walther S, Stegmayer K, Wilson JE, et al. Structure and neural mechanisms of catatonia. Lancet Psychiatry. 2019;6(7):610-619.
  32. 32.Stroup TS, Gray N. Management of common adverse effects of antipsychotic medications. World Psychiatry. 2018;17(3):341-356.

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