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Am Fam Physician. 2023;108(3):235

Is watchful waiting a reasonable alternative to invasive treatment for women 25 to 30 years of age with CIN2?

Based on one prospective cohort study, most lesions regress at least partially within two years without treatment for women 25 to 30 years of age with grade 2 cervical intraepithelial neoplasia (CIN2) confirmed with biopsy and a human papillomavirus (HPV) type that is not 16. Watchful waiting may be appropriate. For women with HPV 16, only 51% had a partial or total regression of CIN2, suggesting that immediate treatment (i.e., loop electrosurgical excision procedure) is warranted. Most progression or regression was evident at 12 months.

Should analgesia be provided for patients with undifferentiated abdominal pain?

Two systematic reviews confirm that controlling pain in patients with acute abdominal pain is patient-centered. Analgesia should be provided because it improves patient comfort, does not hinder the accuracy of the physical examination, and may facilitate the assessment.

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