Testosterone Replacement in Men With Sexual Dysfunction in the Absence of Hypogonadism

Bradley J. Touchet, MD

Verneeta L. Williams, MD

American Family Physician. 2025;111(4):311-312.

Author disclosure: No relevant financial relationships.

BRADLEY J. TOUCHET, MD, and VERNEETA L. WILLIAMS, MD, Virginia Commonwealth University Riverside Family Medicine Residency Program, Newport News.

Address correspondence to Bradley J. Touchet, MD, at bradley.touchet@rivhs.com.

Author disclosure: No relevant financial relationships.

1.Lee H, Hwang EC, Oh CK, et al. Testosterone replacement in men with sexual dysfunction. Cochrane Database Syst Rev. 2024(1):CD013071.
2.Mark KP, Arenella K, Girard A, et al. Erectile dysfunction prevalence in the United States: report from the 2021 National Survey of Sexual Wellbeing. J Sex Med. 2024;21(4):296-303.
3.Salonia A, Bettocchi C, Capogrosso; European Association of Urology. EAU guidelines on sexual and reproductive health. April 2024. Accessed January 15, 2025. https://uroweb.org/guidelines/sexual-and-reproductive-health
4.McCabe M, Althof SE, Assalian P, et al. Psychological and interpersonal dimensions of sexual function and dysfunction. J Sex Med. 2010;7(1 pt 2):327-336.
5.Balon R. Burden of sexual dysfunction. J Sex Marital Ther. 2017;43(1):49-55.
6.U.S. Food and Drug Administration. Testosterone information. March 3, 2015. Accessed January 15, 2025. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/testosterone-information
7.Bhasin S, Brito JP, Cunningham GR, et al. Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2018;103(5):1715-1744.
8.Mulhall JP, Trost LW, Brannigan RE, et al. Evaluation and management of testosterone deficiency: AUA guideline. J Urol. 2018;200(2):423-432.
9.Jasuja GK, Bhasin S, Rose AJ. Patterns of testosterone prescription overuse. Curr Opin Endocrinol Diabetes Obes. 2017;24(3):240-245.

This series is coordinated by Christopher W. Bunt, MD, AFP assistant medical editor, and the NNT Group.

A collection of Medicine by the Numbers published in AFP is available at https:// www.aafp.org/afp/mbtn.

My account