February 15, 2013

A thorough diagnostic evaluation, including history, physical examination, and laboratory testing, is recommended in children younger than 36 months with unexplained fever. Further testing with lumbar puncture and chest radiography may be indicated in neonates and in older…

Parkinson disease affects approximately 1 percent of Americans older than 60 years. Because the symptoms mimic other neurologic conditions, initial diagnosis may be difficult. Pharmacologic and nonpharmacologic therapies are effective in reducing motor impairment and disability…

Although there is general agreement that screening mammography should be offered routinely to women 50 to 74 years of age, there are conflicting guidelines for its use in women 40 to 49 years of age. A reasonable approach to screening mammography is based on expected benefits…

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Screening mammography is one of an increasing number of clinical issues that will require rethinking the clinical mission and restructuring clinical practice to help patients make informed choices.

What are the effects of nondrug and drug treatments for primary insomnia in older persons (those 60 years and older)?

Case Study: A 61-year-old black man presents for a routine checkup. He has hypertension and diabetes mellitus that are well controlled with medication. During the visit, he tells you that a friend advised him to get a prostate-specific antigen (PSA) test to screen for prostate…

Photo Quiz presents readers with a clinical challenge based on a photograph or other image.

Vitamin D supplementation, at a dosage of 100,000 IU per month for 18 months, did not reduce the incidence or severity of URIs in healthy adults. This is the third randomized controlled trial that showed no relationship between vitamin D levels and acute URIs.

The American Academy of Sleep Medicine (AASM) last published recommendations on the treatment of restless legs syndrome (RLS) and periodic limb movement disorder in 2004. It recently updated these recommendations based on a literature review and meta-analysis.

Cholecalciferol (vitamin D3) supplementation should be used for vitamin D repletion because it may be more effective in preventing nonvertebral fractures.

The U.S. Preventive Services Task Force (USPSTF) recommends against prostate-specific antigen (PSA)-based screening for prostate cancer.

Letter

Parkinson disease is a brain disease that usually affects older people. It happens when the parts of the brain that control your muscles are damaged. It can cause shaking and stiffness, and make you move more slowly.

Error in the features of leptospirosis. The article “Hepatitis A” (December 1, 2012, p. 1027) contained an error in Table 2 (p. 1029) regarding the distinguishing features of leptospirosis. The distinguishing features section for leptospirosis should have read: “History of…