April 1, 2018

Precancerous cervical lesions and cervical carcinomas are strongly associated with sexually-transmitted high-risk human papillomavirus (HPV) infection, which causes almost all cervical cancers. Screening with cytology can detect early cervical cancer precursors and early-stage…

Most cervical cancer risk factors relate to increased exposure to human papillomavirus or decreased ability to clear the virus immunologically. Cervical cancer may be detected after a Papanicolaou test result is abnormal, a lesion is visualized on pelvic examination, or…

Patients with rheumatoid arthritis typically present with pain and stiffness in multiple joints, often the wrists, proximal interphalangeal joints, and metacarpophalangeal joints. Some patients may experience extra-articular manifestations affecting the eyes, skin, lungs, and…

It is our responsibility as physicians to help our patients avoid interventions that are not helpful or, worse, potentially harmful.

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Prescription niacin (nicotinic acid, vitamin B3) does not reduce myocardial infarctions, strokes, or overall mortality when used for primary or secondary prevention.

There is only limited-quality evidence that at-risk patients taking GLP-1 receptor agonists are less likely to progress to diabetes (number needed to treat [NNT] = 23). Serious adverse events were more likely in patients taking GLP-1 receptor agonists than in patients taking…

Pneumococcal vaccines had no significant effect on mortality from cardiorespiratory disease when compared with control and had no significant effect on all-cause mortality. Find out more.

An older man presented with increasing fatigue and fingernail deformity.

Providing high-quality, patient-centered care for those living with chronic pain includes developing a good understanding of the many ways the pain affects their lives are affected by their symptoms and validating their concerns and feelings.

Broad-spectrum antibiotics are no more effective than narrow-spectrum antibiotics for treating acute respiratory tract infections in infants and children, and adverse events are significantly more common in children treated with broad-spectrum antibiotics.

At $30,000 per quality-adjusted life year (QALY) gained, early PT for acute low back pain in primary care is cost-effective by the usual criteria of $50,000 to $100,000 per QALY. However, the magnitude of improvement in quality of life is small and is probably not clinically…

The American College of Cardiology (ACC), American Heart Association (AHA), and Heart Rhythm Society (HRS) have released guidelines to assist physicians in evaluating and treating syncope.

Oral bisphosphonates significantly reduce clinical fracture risk at four years in women with postmenopausal osteoporosis (T-score less than -2.5). Treatment beyond five years is associated with further reductions in fractures in women with persistent femoral neck T-scores less…

Physicians should consider not using antipsychotics in patients with dementia. Patients with dementia, including Alzheimer disease, who are treated with antipsychotics for any length of time have a higher mortality rate than those not taking antipsychotics.