Sarecycline (Seysara) for the Treatment of Acne

Safety

As with other drugs in the tetracycline class, sarecycline can cause teratogenic effects. Limited human data demonstrate an association between tetracycline use and subsequent birth defects or miscarriage. Tetracyclines are known to cross the placenta into fetal tissues. Animal studies have shown skeletal defects in offspring. Due to the risk of fetal harm, sarecycline should not be used by pregnant women. Patients suspected of being pregnant should immediately discontinue treatment.1 Sarecycline should not be taken by breastfeeding women because of the risk of adverse effects on infant bone and tooth development.1 In animal studies, sarecycline decreases spermatogenesis at high doses, and decreased fertility may occur in men taking sarecycline.

Like other antibiotics, sarecycline can cause Clostridioides difficile–associated diarrhea.1 Sarecycline should not be administered with oral retinoids because the combination may increase intracranial pressure. Antacids may decrease absorption and should be taken on a separate dosing schedule. Sarecycline can interfere with the bactericidal action of penicillin and should not be administered concurrently. Sarecycline may decrease plasma prothrombin activity, and decreased anticoagulant dosing may be required due to an increased risk of bleeding. Sarecycline has not demonstrated any clinically significant effects on oral contraceptives containing ethinyl estradiol and norethindrone acetate.1

Tolerability

Sarecycline is generally