Disulfiram for the Treatment of Cocaine Dependence

Madhavi Singh, MD,

Gretchen Maurer, DO,

Sophia Smithbauer, DO,

Pennsylvania State University College of Medicine, State College, Pennsylvania

American Family Physician. 2024;110(4):347-348.

Author disclosure: No relevant financial relationships.

This clinical content conforms to AAFP criteria for CME.

Author disclosure: No relevant financial relationships.

1.Traccis F, Minozzi S, Trogu E, et al. Disulfiram for the treatment of cocaine dependence. Cochrane Database Syst Rev. 2024(1):CD007024.
2.Schwartz EKC, Wolkowicz NR, De Aquino JP, et al. Cocaine use disorder (CUD): current clinical perspectives. Subst Abuse Rehabil. 2022;13:25-46.
3.United Nations Office on Drugs and Crime. Booklet 4: Drug market trends of cocaine, amphetamine-type stimulants, and new psychoactive substances. In: World Drug Report 2022. Accessed June 8, 2024. https://www.unodc.org/res/wdr2022/MS/WDR22_Booklet_4.pdf
4.Substance Abuse and Mental Health Services Administration. Key Substance Use and Mental Health Indicators in the United States: Results from the 2021 National Survey on Drug Use and Health. SAMHSA; 2022. HHS Publication No. PEP22-07-01-005, NSDUH Series H-57. Accessed June 8, 2024. https://www.samhsa.gov/data/sites/default/files/reports/rpt39443/2021NSDUHFFRRev010323.pdf
5.Lanz J, Biniaz-Harris N, Kuvaldina M, et al. Disulfiram: mechanisms, applications, and challenges. Antibiotics (Basel). 2023;12(3):524.

These are summaries of reviews from the Cochrane Library.

This series is coordinated by Corey D. Fogleman, MD, assistant medical editor.

A collection of Cochrane for Clinicians published in AFP is available at https://www.aafp.org/afp/cochrane.

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