Gepirone (Exxua) for the Treatment of Major Depressive Disorder

Stephen R. Foster; Kodi M. Liddell

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STEPS

New Drug Reviews

Gepirone (Exxua) for the Treatment of Major Depressive Disorder

Stephen R. Foster, MD

Kodi M. Liddell, PharmD, BCPS, BCACP

American Family Physician. 2025;111(1):87-88.

Author disclosure: No relevant financial relationships.

STEPHEN R. FOSTER, MD, and KODI M. LIDDELL, PharmD, BCPS, BCACP, University of Arkansas for Medical Sciences, Little Rock

Address correspondence to Stephen R. Foster, MD, at SRFoster2@uams.edu.

Author disclosure: No relevant financial relationships.

1.DailyMed. Drug label information. Exxua–gepirone tablet, extended release. Updated February 12, 2024. Accessed February 12, 2024. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=28b360dc-6337-4cae-a5bb-79f974b5a3b2#ID_e87c6884-e516-45e7-8318-1c664c6a51a5
2.Alpert JE, Franznick DA, Hollander SB, et al. Gepirone extended-release treatment of anxious depression: evidence from a retrospective subgroup analysis in patients with major depressive disorder. J Clin Psychiatry. 2004;65(8):1069-1075.
3.Zimmerman M, Posternak MA, Chelminski I. Is the cutoff to define remission on the Hamilton Rating Scale for Depression too high? J Nerv Ment Dis. 2005;193(3):170-175.
4.Rodríguez L. November 2023 Newsletter: Gepirone for MDD, parasomnias triggered by antidepressant medication, and psychodynamic psychopharmacology. Psychopharmacology Institute. November 1, 2023. Accessed August 12, 2024. https://psychopharmacologyinstitute.com/publication/november-2023-newsletter-gepirone-for-mdd-parasomnias-triggered-by-antidepressantmedication-and-psychodynamic-psychopharmacology-2825
5.DrugPatentWatch. Exxua Drug Profile. Accessed December 4, 2024. https://www.drugpatentwatch.com/blog/shop/exxua-gepirone-hydrochloride-drug-profile-2024/
6.GoodRx. Citalopram. Accessed December 10, 2024. https://www.goodrx.com/citalopram

STEPS new drug reviews cover Safety, Tolerability, Effectiveness, Price, and Simplicity. Each independent review is provided by authors who have no financial association with the drug manufacturer.

This series is coordinated by Allen F. Shaughnessy, PharmD, assistant medical editor.

A collection of STEPS published in AFP is available at https://www.aafp.org/afp/steps.