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Medicine by the Numbers

Alpha-Lipoic Acid for Diabetic Peripheral Neuropathy

Sarah M. Abuali, MD, MPH, MS
D. Jason Frasca, DO, FAAFP

American Family Physician. 2025;111(2):119-120.

Author disclosure: No relevant financial relationships.

SARAH M. ABUALI, MD, MPH, MS, and D. JASON FRASCA, DO, FAAFP, Virginia Commonwealth University Riverside Family Medicine Residency Program, Newport News, Virginia

Address correspondence to Sarah M. Abuali, MD, MPH, MS, at sarahabuali@gmail.com.

Author disclosure: No relevant financial relationships.

  1. 1.Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107843.
  2. 2.Ziegler D, Tesfaye S, Spallone V, et al. Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: international expert consensus recommendations. Diabetes Res Clin Pract. 2022;186:109063.
  3. 3.Amin N, Doupis J. Diabetic foot disease: from the evaluation of the “foot at risk” to the novel diabetic ulcer treatment modalities. World J Diabetes. 2016;7(7):153-164.
  4. 4.Rochette L, Ghibu S, Muresan A, et al. Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes. Can J Physiol Pharmacol. 2015;93(12):1021-1027.
  5. 5.Baicus C, Purcarea A, von Elm E, et al. Alpha-lipoic acid for diabetic peripheral neuropathy. Cochrane Database Syst Rev. 2024(1):CD012967.

Copyright ©2026 MD Aware, LLC (theNNT.com). Used with permission.

This series is coordinated by Christopher W. Bunt, MD, AFP assistant medical editor, and the NNT Group.

A collection of Medicine by the Numbers published in AFP is available at https:// www.aafp.org/afp/mbtn.

Previous article
SGLT-2 for Diabetes, Biliary Pain, Depression in Adolescents, Intermittent Catheterization, Labor Induction, Umbilical Hernias, Multivitamins
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Interventions for Fatigue in Patients With Kidney Failure Who Are Receiving Dialysis

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