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Medicine by the Numbers

Fidaxomicin vs Vancomycin for Clostridioides difficile Infection

Fatima Johari, MD
Kelsey Sklar, MD, MPH

American Family Physician. 2025;111(6):493-494.

Author disclosure: No relevant financial relationships.

FATIMA JOHARI, MD, Northwell Health, Manhasset, New York

KELSEY SKLAR, MD, MPH, SUNY Downstate Health Sciences University, Brooklyn, New York, and NYC Health + Hospitals/Kings County, Brooklyn

Address correspondence to Fatima Johari, MD, at fjohari@northwell.edu.

Author disclosure: No relevant financial relationships.

  1. 1.Beinortas T, Burr NE, Wilcox MH, et al. Comparative efficacy of treatments for Clostridium difficile infection: a systematic review and network meta-analysis. Lancet Infect Dis. 2018;18(9):1035-1044.
  2. 2.Ma GK, Brensinger CM, Wu Q, et al. Increasing incidence of multiply recurrent Clostridium difficile infection in the United States: a cohort study. Ann Intern Med. 2017;167(3):152-158.
  3. 3.Zhang S, Palazuelos-Munoz S, Balsells EM, et al. Cost of hospital management of Clostridium difficile infection in United States—a meta-analysis and modelling study. BMC Infect Dis. 2016;16(1):447.
  4. 4.Johnson S, Lavergne V, Skinner AM, et al. Clinical practice guideline by the Infectious Diseases Society of American (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 focused update guidelines on management of Clostridioides difficile infection in adults. Clin Infect Dis. 2021;73(5):e1029-e1044.
  5. 5.Weiss K, Allgren RL, Sellers S. Safety analysis of fidaxomicin in comparison with oral vancomycin for Clostridium difficile infections. Clin Infect Dis. 2012;55(suppl 2):S110-S115.
  6. 6.Guery B, Menichetti F, Anttila V-J, et al. Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection in patients 60 years and older (EXTEND): a randomised, controlled, open-label, phase 3b/4 trial. Lancet Infect Dis. 2018;18(3):296-307.
  7. 7.GoodRx. Dificid (fidaxomicin). Accessed March 1, 2025. https://www.goodrx.com/dificid
  8. 8.GoodRx. Vancomycin. Accessed March 1, 2025. https://www.goodrx.com/vancomycin

Copyright ©2026 MD Aware, LLC (theNNT.com). Used with permission.

This series is coordinated by Christopher W. Bunt, MD, AFP assistant medical editor, and the NNT Group.

A collection of Medicine by the Numbers published in AFP is available at https:// www.aafp.org/afp/mbtn.

Previous article
Cancer Screenings, Cognitive Rehabilitation, Morton Neuroma, Wearable Smart Devices, Falls in Older Adults, Obsessive-Compulsive Disorder
Jun 2025
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Blood Pressure Targets for Hypertension in People With Chronic Kidney Disease

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