June 2025

Articles

Acute Monoarthritis: Diagnosis in Adults

Jeremy Swisher, Zachary Sitton, Kimberly Burbank, Chris Nelson

The most common causes of acute monoarthritis include osteoarthritis, gout, pseudogout, and trauma. Septic arthritis is a less common cause, but it necessitates urgent intervention.

Long-Term Opioid Therapy for Nonterminal Pain

Kento Sonoda, Mako Wakabayashi

Health disparities in pain management tend to affect vulnerable populations. Clinicians must acknowledge the inequities and stigma surrounding chronic pain and need to provide culturally tailored pain management. First-line therapies include nonopioid drugs; long-term opioid…

CMEAlgUrologic

Nocturia: Evaluation and Management

Feven W. Getaneh, Rachael D. Sussman, Cheryl B. Iglesia

Nocturia (ie, awakening to void during the night) is clinically significant if it occurs two or more times per night. Lifestyle modifications and treatment of underlying comorbidities are first-line therapies. The addition of pharmacotherapy may be considered. Patients with…

Endometrial Cancer: Rapid Evidence Review

Carl Bryce, Renee Gazda, Hadass Fuerst

North America has the highest global incidence of endometrial cancer, and the incidence and mortality rates are increasing. Abnormal uterine bleeding, especially postmenopausal bleeding, is the most common symptom.

Evaluation of Short and Tall Stature in Children

Rebecca Caro, Paul Savel, Paul Isaiah Moss

The first step in the evaluation of short and tall stature in children is to record and plot growth measurements on a growth curve. Short stature is defined as height that is more than 2 standard deviations below the mean height for age; tall stature is defined as height that…

Inside AFP

Historical Perspectives on Race-Based Medicine in American Family Physician

Kenneth W. Lin, Priscilla Auguste, Christopher W. Bunt, Michelle Nelson

With notable exceptions, past authors and editors of American Family Physician mostly treated race and ethnicity as sociopolitical constructs rather than inherent biologic traits.

Editorials

Family Physicians Should Generate Our Own Data and Guidelines to Help Patients With Sinusitis

Dan Merenstein

Global overuse of antibiotics increases antibiotic resistance and unnecessary medication-related adverse events; reducing inappropriate prescribing for acute rhinosinusitis is crucial to limiting the development and spread of antibiotic resistance.

AFP Clinical Answers

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Cancer Screenings, Cognitive Rehabilitation, Morton Neuroma, Wearable Smart Devices, Falls in Older Adults, Obsessive-Compulsive Disorder

Key clinical questions and their evidence-based answers directly from the journal’s content, written by and for family physicians.

Medicine by the Numbers

Fidaxomicin vs Vancomycin for Clostridioides difficile Infection

Fatima Johari, Kelsey Sklar

Given the existing evidence, we have assigned a color recommendation of green (benefits greater than harms) for fidaxomicin compared with vancomycin for the treatment of C difficile infections.

Cochrane for Clinicians

Blood Pressure Targets for Hypertension in People With Chronic Kidney Disease

Tara Devaraj, Karl T. Clebak, Zakary S. Newberry

Having a lower blood pressure target of 130/80 mm Hg for hypertension in people with chronic kidney disease compared with a higher blood pressure target of 140 to 160/90 to 100 mm Hg does not reduce total mortality, total serious adverse events, total cardiovascular events…

Educational Interventions Improve Adverse Drug Reaction Reporting

Elizabeth Chiang, Rashmi Rode, Arindam Sarkar

When combined with adverse drug reaction reporting forms and reminder cards, educational interventions improve the overall reporting rate by health care professionals compared with standard spontaneous reporting. Improving hospital-based health care professionals’ access to…

FPIN's Clinical Inquiries

Buprenorphine-Naloxone for Pregnant Patients With Opioid Use Disorder

Ellen Tran, Sarah Peterson, Dara Jolly, Jon O. Neher

Buprenorphine-naloxone can be used to treat opioid use disorder in pregnant patients. It has an obstetric safety profile similar to those of alternative treatments for this disorder and is associated with a lower rate of neonatal opioid withdrawal syndrome.

Photo Quiz

Bullous Rash on the Face and Neck

Jason Burchett

A 27-year-old man presented with a rash that was not painful or pruritic.

Hypertrophic Nodules on the Knuckles

Rayyan Quip, Jennifer Wolf

A 44-year-old woman presented with pruritic hand lesions that had been present for several years.

STEPS

Lecanemab (Leqembi) for the Slowing of Alzheimer Disease

Megan L. Hull, Megan Adelman

Lecanemab is an expensive treatment option with noteworthy potential risks and should be prescribed for select patients (ie, with early disease and confirmed amyloid plaque deposition) who understand the ratio of benefit to risk and who can afford it.

Lown Right Care

Inappropriate Use of Oral Antiplatelet Drugs

Alan Roth, Andy Lazris, Helen Haskell, John James

A collaboration between AFP and the Lown Institute promotes a vision of delivering health care that is based on the evidence, balanced in its approach, and focused on the patient.

Point-of-Care Guides

Assessing the Risk of Developing Atrial Fibrillation

Mark H. Ebell

How can patients at high risk for developing atrial fibrillation be identified?

Diagnostic Tests

Simple 2 Test for At-Home Gonorrhea and Chlamydia Testing

Tyler J. Raymond, Elizabeth McCarthy Depavloff

When compared with in-office testing, the Simple 2 Test accurately detects gonorrhea and chlamydia in adults 18 years and older who desire at-home testing. It addresses stigma concerns and barriers that patients may encounter when seeking in-clinic screening and improves STI…

Diary of a Family Physician

Diary of a Family Physician

ANGELA RODGERS

First-person accounts from the front lines of family medicine.

POEMs

Practice Guidelines

Diagnosis and Treatment of Diabetes-Related Foot Infections: Guidelines From the IWGDF/IDSA

Michael J. Arnold

The International Working Group on the Diabetic Foot (IWGDF) and Infectious Diseases Society of America (IDSA) have published guidelines on diagnosis and treatment of these infections.

CME Course Information

Evidence-based Medicine Toolkit

Strength of Recommendation Taxonomy

Advertising: Career Opportunities (PDF download)

Disclosures

All editors in a position to control content for this activity, AFP journal, are required to disclose any relevant financial relationships. View disclosures.

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