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FPIN's Clinical Inquiries
From the Family Practice Inquiries Network

Buprenorphine-Naloxone for Pregnant Patients With Opioid Use Disorder

Ellen Tran, DO
Sarah Peterson, MD
Dara Jolly, MD
Jon O. Neher, MD

American Family Physician. 2025;111(6):543-544.

Author disclosure: No relevant financial relationships.

ELLEN TRAN, DO; SARAH PETERSON, MD; DARA JOLLY, MD; and JON O. NEHER, MD, University of Washington Medicine/Valley Medical Center Family Medicine Residency, Renton

Address correspondence to Ellen Tran, DO, at ellen_tran@valleymed.org.

Author disclosure: No relevant financial relationships.

  1. 1.Link HM, Jones H, Miller L, et al. Buprenorphine-naloxone use in pregnancy: a systematic review and metaanalysis. Am J Obstet Gynecol MFM. 2020;2(3):100179.
  2. 2.Kinsella M, Halliday LOE, Shaw M, et al. Buprenorphine compared with methadone in pregnancy: a systematic review and meta-analysis. Subst Use Misuse. 2022;57(9):1400-1416.
  3. 3.Perry BN, Vais S, Boateng JO, et al. Buprenorphine-naloxone versus buprenorphine for treatment of opioid use disorder in pregnancy. J Addict Med. 2022;16(6):e399-e404.
  4. 4.Kanervo MM, Tupola SJ, Nikkola EM, et al. Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder. Acta Obstet Gynecol Scand. 2023;102(3):313-322.
  5. 5.Committee Opinion No. 711: Opioid use and opioid use disorder in pregnancy. Obstet Gynecol. 2017;130(2):e81-e94.
  6. 6.ACOG Publications: October 2021. Obstet Gynecol. 2021;138(4):686-687.

Clinical Inquiries provides answers to questions submitted by practicing family physicians to the Family Physicians Inquiries Network (FPIN). Members of the network select questions based on their relevance to family medicine. Answers are drawn from an approved set of evidence-based resources and undergo peer review. The strength of recommendations and the level of evidence for individual studies are rated using criteria developed by the Evidence-Based Medicine Working Group (https://www.cebm.net).

The complete database of evidence-based questions and answers is copyrighted by FPIN. If interested in submitting questions or writing answers for this series, go to https://www.fpin.org or email questions@fpin.org.

Copyright © Family Physicians Inquiries Network. Used with permission.

This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor.

A collection of FPIN’s Clinical Inquiries published in AFP is available at https://www.aafp.org/afp/fpin.

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