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Diary of a Family Physician
Diagnostic Tests

Simple 2 Test for At-Home Gonorrhea and Chlamydia Testing

Tyler J. Raymond, DO, MPH
Elizabeth McCarthy Depavloff, MD

American Family Physician. 2025;111(6):556-557.

Author disclosure: No relevant financial relationships.

TYLER J. RAYMOND, DO, MPH, FAAFP, Uniformed Services University of Health Sciences, Bethesda, Maryland

ELIZABETH MCCARTHY DEPAVLOFF, MD, Madigan Army Medical Center Family Medicine Residency, Tacoma, Washington

Address correspondence to Tyler J. Raymond, DO, MPH, FAAFP, at drtylerraymond@gmail.com.

Author disclosure: No relevant financial relationships.

  1. 1.LetsGetChecked.com. Simple 2 Test. Accessed October 22, 2024. https://www.letsgetchecked.com/simple-std-test/
  2. 2.US Food and Drug Administration. FDA grants marketing authorization of first test for chlamydia and gonorrhea with at-home sample collection. November 13, 2023. Accessed September 13, 2024. https://www.fda.gov/news-events/press-announcements/fda-grants-marketing-authorization-first-test-chlamydia-and-gonorrhea-home-sample-collection
  3. 3.WHO Consolidated Guideline on Self-Care Interventions For Health: Sexual and Reproductive Health and Rights. World Health Organization; 2019.
  4. 4.Aptima Combo 2 assay [package Insert]. Hologic, Inc. Accessed September 13, 2024. https://www.hologic.com/sites/default/files/package-insert/502487-IFU-PI_001_01.pdf
  5. 5.Exten C, Pinto CN, Gaynor AM, et al. Direct-to-consumer sexually transmitted infection testing services: a position statement from the American Sexually Transmitted Diseases Association. Sex Transm Dis. 2021;48(11):e155-e159.
  6. 6.Wilson E, Free C, Morris TP, et al. Internet-accessed sexually transmitted infection (e-STI) testing and results service: a randomised, single-blind, controlled trial. PLoS Med. 2017;14(12):e1002479.
  7. 7.Morris SR, Bristow CC, Wierzbicki MR, et al. Performance of a single-use, rapid, point-of-care PCR device for the detection of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis: a cross-sectional study. Lancet Infect Dis. 2021;21(5):668-676.
  8. 8.Kersh EN, Mena LA. At-home diagnostics solutions for chlamydia and gonorrhea. JAMA. 2024;331(20):1701-1702.

This series is coordinated by Natasha Pyzocha, DO, contributing editor.

A collection of Diagnostic Tests published in AFP is available at https://www.aafp.org/afp/diagnostic.

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