May 2025

In the United States, the average age of menopause is 52 years. Women will spend approximately one-third of their lives postmenopausal; therefore, physicians should be familiar with primary preventive care recommendations in this patient population.

Although most routine childhood immunizations have remained the same for the past 10 years, recommendations for COVID-19, pneumococcal, and respiratory syncytial virus vaccines have been updated.

Trigeminal neuralgia is a chronic neuropathic pain condition that causes sudden, brief episodes of electric shock–like, lancinating pain in one or more trigeminal nerve distributions. Brain magnetic resonance imaging with and without contrast media is recommended for all…

Female sexual dysfunction is common, affecting 40% to 50% of women. Using a biopsychosocial model, understanding the patient’s symptoms, and recognizing associated distress are essential for optimal treatment.

Goals of migraine prophylaxis include reduction in headache severity and frequency, improved response to acute treatment, fewer days with disability, improvement in quality of life, and empowerment of patients with a sense of control. Indications for consideration of preventive…

An occupational musculoskeletal disorder is an injury or condition of bone, muscle, nerve, cartilage, tendon, ligament, or other soft tissue that is caused or exacerbated by occupational activities. Family physicians play a valuable role in diagnosis, management, and treatment…

Unintended pregnancies can negatively affect financial, health, educational, and social outcomes. Through clinical care and influencing policies in the health care system, primary care clinicians can reduce the inequitable impacts of unintended pregnancies.

American Family Physician documents the changing status of women as both patients and physicians over the past 75 years and the progress that has been made.

Peer review is an essential and valuable process for American Family Physician, and we are grateful for the work reviewers do to help us develop sound content. AFP acknowledges and thanks all people who reviewed at least one AFP article in 2024.

Given the suboptimal dosing of methotrexate and low certainty of evidence, we assigned a color recommendation of yellow (unclear benefits). Further research with optimal dosing of methotrexate and longer follow-up is needed to properly assess the use of methotrexate in JIA…

Sodium-glucose cotransporter-2 (SGLT-2) inhibitors reduce the mortality risk in people with any stage chronic kidney disease and type 2 diabetes. Although it is unclear whether SGLT-2 inhibitors reduce major adverse cardiac events, they reduce the risk of kidney failure and…

Transcutaneous electrical nerve stimulation (TENS), regardless of frequency, seems to reduce pain associated with primary dysmenorrhea compared with placebo or no treatment. It is uncertain whether TENS has a better analgesic effect than acupressure, acetaminophen, nonsteroidal…

Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals that are widely used in industry and commonly found in the environment. There are thousands of different PFAS, but some have been studied more comprehensively than others (eg, perfluorooctanoic acid…

Topical testosterone can be used to manage sexual function and vaginal symptoms associated with menopause. Combined with estrogen replacement therapy, topical testosterone increases the number of satisfying sexual episodes compared with placebo.

Due to its high cost and the availability of well-tolerated, well-studied alternatives, zuranolone therapy should be reserved for the few patients for whom no other treatment options are available.

A 30-year-old man presented to the emergency department after the sole of his foot impacted a rock in a shallow pool of water.

A 6-week-old male infant presented with fever, congestion, and a rash.

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The American Thoracic Society published guidelines on the management of persistent obstructive sleep apnea in children after adenotonsillectomy. All recommendations are suggestions that apply to some patients, but they are not strong recommendations because of very low-quality…

Reply: Jennifer G. Chang

Reply: Winfred Frazier, Raquel Zemtsov

Reply: Winfred Frazier, Raquel Zemtsov