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STEPS
New Drug Reviews

Zuranolone (Zurzuvae) for the Treatment of Postpartum Depression

James Montgomery, PharmD, BCACP
Alexander Hoffman, PharmD, MEd, BCPS, CDCES

American Family Physician. 2025;111(5):465-466.

Author disclosure: No relevant financial relationships.

JAMES MONTGOMERY, PHARMD, BCACP, and ALEXANDER HOFFMAN, PHARMD, MED, BCPS, CDCES, Cleveland Clinic, Cleveland, Ohio

Address correspondence to James Montgomery, PharmD, BCACP, at montgoj5@ccf.org.

Author disclosure: No relevant financial relationships.

  1. 1.Daily Med. Drug label information. Zurzuvae – zuranolone capsule. Accessed June 25, 2024. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f18e53b0-d0bb-422d-8de7-ab64b7292b29
  2. 2.Deligiannidis KM, Meltzer-Brody S, Maximos B, et al. Zuranolone for the treatment of postpartum depression. Am J Psychiatry. 2023;180(9):668-675.
  3. 3.Deligiannidis KM, Meltzer-Brody S, Gunduz-Bruce H, et al. Effect of zuranolone vs placebo in postpartum depression: a randomized clinical trial. JAMA Psychiatry. 2021;78(9):951-959.
  4. 4.Hengartner MP, Plöderl M. Estimates of the minimal important difference to evaluate the clinical significance of antidepressants in the acute treatment of moderate-to-severe depression. BMJ Evid Based Med. 2022;27(2):69-73.
  5. 5.Clayton AH, Suthoff E, Jain R, et al. The magnitude and sustainability of treatment benefit of zuranolone on function and well-being as assessed by the SF-36 in adult patients with MDD and PPD: an integrated analysis of 4 randomized clinical trials. J Affect Disord. 2024;351:904-914.
  6. 6.UpToDate Lexidrug. Zuranolone [drug information]. Accessed March 28, 2025. http://online.lexi.com

STEPS new drug reviews cover Safety, Tolerability, Effectiveness, Price, and Simplicity. Each independent review is provided by authors who have no financial association with the drug manufacturer.

This series is coordinated by Allen F. Shaughnessy, PharmD, assistant medical editor.

A collection of STEPS published in AFP is available at https://www.aafp.org/afp/steps.

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